Search Results - "O’Brien, Maureen M"

Lineage Switch in MLL-Rearranged Infant Leukemia Following CD19-Directed Therapy by Rayes, Ahmad, McMasters, Richard L., O'Brien, Maureen M.

“…Rearrangements of the mixed lineage leukemia (MLL) gene occur frequently in infants with both acute lymphoblastic leukemia (ALL) and acute myeloid leukemia…”
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Second Malignant Neoplasms in Survivors of Pediatric Hodgkin's Lymphoma Treated With Low-Dose Radiation and Chemotherapy by M O'BRIEN, Maureen, DONALDSON, Sarah S, BALISE, Raymond R, WHITTEMORE, Alice S, LINK, Michael P

“…Survivors of childhood Hodgkin's lymphoma (HL) are at risk for second malignant neoplasms (SMNs). It is theorized that this risk may be attenuated in patients…”
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Phase 1b study of carfilzomib with induction chemotherapy in pediatric relapsed/refractory acute lymphoblastic leukemia by Burke, Michael J., Ziegler, David S., Bautista, Francisco, Attarbaschi, Andishe, Gore, Lia, Locatelli, Franco, M. O'Brien, Maureen, Pauly, Melinda, Kormany, William N., Tian, Shengqi, Morris, Christopher L., Baruchel, Andre

“…Background Acute lymphoblastic leukemia (ALL) is the most common cancer diagnosed in childhood. Survival for patients following relapse remains poor, and…”
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Rising Incidence of Oropharyngeal Cancer and the Role of Oncogenic Human Papilloma Virus by Ernster, Joel A., Sciotto, Cosimo G., O'Brien, Maureen M., Finch, Jack L., Robinson, Linda J., Willson, Thomas, Mathews, Michael

“…Objectives/Hypothesis: To document the increasing incidence of oropharyngeal (OP) cancer and to provide evidence that this increase is caused by oncogenic…”
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Modulation of CD22 Protein Expression in Childhood Leukemia by Pervasive Splicing Aberrations: Implications for CD22-Directed Immunotherapies by Zheng, Sisi, Gillespie, Elisabeth, Naqvi, Ammar S, Hayer, Katharina E, Ang, Zhiwei, Torres-Diz, Manuel, Quesnel-Vallières, Mathieu, Hottman, David A, Bagashev, Asen, Chukinas, John, Schmidt, Carolin, Asnani, Mukta, Shraim, Rawan, Taylor, Deanne M, Rheingold, Susan R, O'Brien, Maureen M, Singh, Nathan, Lynch, Kristen W, Ruella, Marco, Barash, Yoseph, Tasian, Sarah K, Thomas-Tikhonenko, Andrei

“…Downregulation of surface epitopes causes postimmunotherapy relapses in B-lymphoblastic leukemia (B-ALL). Here we demonstrate that mRNA encoding CD22 undergoes…”
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Clinical covariates that improve the description of high dose methotrexate pharmacokinetics in a diverse population to inform MTXPK.org by Taylor, Zachary L, Miller, Tamara P, Poweleit, Ethan A, DeGroote, Nicholas P, Pommert, Lauren, Awoniyi, Oluwafunbi, Board, Sarah G, Ugboh, Ngozi, Joshi, Vivek, Ambrosino, Nick, Chavana, Ashley, Bernhardt, Melanie B, Schafer, Eric S, O'Brien, Maureen M, Castellino, Sharon M, Ramsey, Laura B

“…The MTXPK.org webtool was launched in December 2019 and was developed to facilitate model-informed supportive care and optimal use of glucarpidase following…”
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Cardiomyopathy in Children With Down Syndrome Treated for Acute Myeloid Leukemia: A Report From the Children's Oncology Group Study POG 9421 by O'BRIEN, Maureen M, TAUB, Jeffrey W, CHANG, Myron N, MASSEY, Gita V, STINE, Kimo C, RAIMONDI, Susana C, BECTON, David, RAVINDRANATH, Yaddanapudi, DAHL, Gary V

“…To determine the outcomes, with particular attention to toxicity, of children with Down syndrome (DS) and acute myeloid leukemia (AML) treated on Pediatric…”
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Bupivacaine use in the Insuflow® device during laparoscopic cholecystectomy: results of a prospective randomized double-blind controlled trial by Zimmer, Peter W., McCann, Michael J., O’Brien, Maureen M.

“…Background Recent evidence [Surg Endosc (2007) 21: 602–606] demonstrates that intraperitoneal bupivacaine administered as an aerosol via a special catheter is…”
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Inotuzumab ozogamicin in pediatric patients with relapsed/refractory acute lymphoblastic leukemia by Bhojwani, Deepa, Sposto, Richard, Shah, Nirali N., Rodriguez, Vilmarie, Yuan, Constance, Stetler-Stevenson, Maryalice, O’Brien, Maureen M., McNeer, Jennifer L., Quereshi, Amrana, Cabannes, Aurelie, Schlegel, Paul, Rossig, Claudia, Dalla-Pozza, Luciano, August, Keith, Alexander, Sarah, Bourquin, Jean-Pierre, Zwaan, Michel, Raetz, Elizabeth A., Loh, Mignon L., Rheingold, Susan R.

“…Although inotuzumab ozogamicin (InO) is recognized as an effective agent in relapsed acute lymphoblastic leukemia (ALL) in adults, data on safety and efficacy…”
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Only the beginning: 50 years of progress toward curing childhood cancer by Gore, Lia, O'Brien, Maureen M

“…Dramatic progress in treating childhood cancer has evolved over decades from initial empirically derived treatments to clinical investigations incorporating…”
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Defining the Optimal Treatment of First Relapse of Pediatric Relapsed Anaplastic Large-Cell Lymphoma: Clinical Trial Challenges for Rare Diagnoses by O'Brien, Maureen M

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Phase I/Phase II Study of Blinatumomab in Pediatric Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia by von Stackelberg, Arend, Locatelli, Franco, Zugmaier, Gerhard, Handgretinger, Rupert, Trippett, Tanya M, Rizzari, Carmelo, Bader, Peter, O'Brien, Maureen M, Brethon, Benoît, Bhojwani, Deepa, Schlegel, Paul Gerhardt, Borkhardt, Arndt, Rheingold, Susan R, Cooper, Todd Michael, Zwaan, Christian M, Barnette, Phillip, Messina, Chiara, Michel, Gérard, DuBois, Steven G, Hu, Kuolung, Zhu, Min, Whitlock, James A, Gore, Lia

“…Purpose Blinatumomab is a bispecific T-cell engager antibody construct targeting CD19 on B-cell lymphoblasts. We evaluated the safety, pharmacokinetics,…”
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Consensus Guideline for Use of Glucarpidase in Patients with High‐Dose Methotrexate Induced Acute Kidney Injury and Delayed Methotrexate Clearance by Ramsey, Laura B., Balis, Frank M., O'Brien, Maureen M., Schmiegelow, Kjeld, Pauley, Jennifer L., Bleyer, Archie, Widemann, Brigitte C., Askenazi, David, Bergeron, Sharon, Shirali, Anushree, Schwartz, Stefan, Vinks, Alexander A., Heldrup, Jesper

“…Acute kidney injury due to high‐dose methotrexate (HDMTX) is a serious, life‐threatening toxicity that can occur in pediatric and adult patients. Glucarpidase…”
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Phase II Trial of Inotuzumab Ozogamicin in Children and Adolescents With Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia: Children's Oncology Group Protocol AALL1621 by O'Brien, Maureen M, Ji, Lingyun, Shah, Nirali N, Rheingold, Susan R, Bhojwani, Deepa, Yuan, Constance M, Xu, Xinxin, Yi, Joanna S, Harris, Andrew C, Brown, Patrick A, Borowitz, Michael J, Militano, Olga, Kairalla, John, Devidas, Meenakshi, Raetz, Elizabeth A, Gore, Lia, Loh, Mignon L

“…Children's Oncology Group trial AALL1621 was conducted to prospectively determine the safety and efficacy of inotuzumab ozogamicin (InO) in pediatric and…”
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Bortezomib reinduction chemotherapy in high‐risk ALL in first relapse: a report from the Children's Oncology Group by Horton, Terzah M., Whitlock, James A., Lu, Xiaomin, O'Brien, Maureen M., Borowitz, Michael J., Devidas, Meenakshi, Raetz, Elizabeth A., Brown, Patrick A., Carroll, William L., Hunger, Stephen P.

“…Summary While survival in paediatric acute lymphoblastic leukaemia (ALL) is excellent, survival following relapse is poor. Previous studies suggest proteasome…”
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Significant effect of infection and food intake on sirolimus pharmacokinetics and exposure in pediatric patients with acute lymphoblastic leukemia by Mizuno, Tomoyuki, O'Brien, Maureen M., Vinks, Alexander A.

“…Sirolimus is increasingly investigated as a new targeted therapy in pediatric populations. To date, population pharmacokinetic (PK) studies have identified…”
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Inotuzumab ozogamicin in B-cell precursor acute lymphoblastic leukemia: efficacy, toxicity, and practical considerations by Rubinstein, Jeremy D, O'Brien, Maureen M

“…Inotuzumab ozogamicin (InO) is an antibody drug conjugate composed of a humanized monoclonal antibody targeting the cell surface receptor CD22 coupled to a…”
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Delayed methotrexate clearance in patients with acute lymphoblastic leukemia concurrently receiving dasatinib by Ramsey, Laura B., Mizuno, Tomoyuki, Vinks, Alexander A., O'Brien, Maureen M.

“…We aimed to determine whether patients receiving dasatinib or imatinib concurrently with high‐dose methotrexate (HDMTX) had slower methotrexate clearance than…”
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Modest serum creatinine elevation affects adverse outcome after general surgery by O'Brien, Maureen M., Gonzales, Ralph, Shroyer, A. Laurie, Grunwald, Gary K., Daley, Jennifer, Henderson, William G., Khuri, Shukri F., Anderson, Robert J.

“…Modest serum creatinine elevation affects adverse outcome after general surgery. Modest preoperative serum creatinine elevation (1.5 to 3.0 mg/dL) has been…”
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Understanding the Risk of Second Malignant Tumors in Children With Hodgkin's Disease by Donaldson, Sarah S., M.D, O'Brien, Maureen M., M.D

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