Search Results - "O’Brien, Lucy"

Tissue Homeostasis and Non-Homeostasis: From Cell Life Cycles to Organ States by O'Brien, Lucy Erin

“…Although tissue homeostasis-the steady state-implies stability, our organs are in a state of continual, large-scale cellular flux. This flux underpins an…”
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Altered Modes of Stem Cell Division Drive Adaptive Intestinal Growth by O'Brien, Lucy Erin, Soliman, Sarah S., Li, Xinghua, Bilder, David

“…Throughout life, adult organs continually adapt to variable environmental factors. Adaptive mechanisms must fundamentally differ from homeostatic maintenance,…”
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Disruption of EGF Feedback by Intestinal Tumors and Neighboring Cells in Drosophila by Ngo, Sang, Liang, Jackson, Su, Yu-Han, O’Brien, Lucy Erin

“…In healthy adult organs, robust feedback mechanisms control cell turnover to enforce homeostatic equilibrium between cell division and death [1, 2]. Nascent…”
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Bellymount enables longitudinal, intravital imaging of abdominal organs and the gut microbiota in adult Drosophila by Koyama, Leslie Ann Jaramillo, Aranda-Díaz, Andrés, Su, Yu-Han, Balachandra, Shruthi, Martin, Judy Lisette, Ludington, William B, Huang, Kerwyn Casey, O'Brien, Lucy Erin

“…Cell- and tissue-level processes often occur across days or weeks, but few imaging methods can capture such long timescales. Here, we describe Bellymount, a…”
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Beyond the Niche: Tissue-Level Coordination of Stem Cell Dynamics by O'Brien, Lucy Erin, Bilder, David

“…Adult animals rely on populations of stem cells to ensure organ function throughout their lifetime. Stem cells are governed by signals from stem cell niches,…”
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A gut feeling for cellular fate by Liang, Jackson, O'Brien, Lucy Erin

“…A population of progenitor cells in the midgut of fruit flies undergoes differentiation in response to mechanical force. This finding marks the first time that…”
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Is quality of life related to high autistic traits, high ADHD traits and their Interaction? Evidence from a Young-Adult Community-Based twin sample by Capp, Simone J., Agnew-Blais, Jessica, Lau-Zhu, Alex, Colvert, Emma, Tye, Charlotte, Aydin, Ümit, Lautarescu, Alexandra, Ellis, Claire, Saunders, Tyler, O’Brien, Lucy, Ronald, Angelica, Happé, Francesca, McLoughlin, Gráinne

“…This study explored whether high autistic traits, high attention deficit hyperactivity disorder (ADHD) traits and their interaction were associated with…”
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The nature of cell division forces in epithelial monolayers by Gupta, Vivek K, Nam, Sungmin, Yim, Donghyun, Camuglia, Jaclyn, Martin, Judy Lisette, Sanders, Erin Nicole, O'Brien, Lucy Erin, Martin, Adam C, Kim, Taeyoon, Chaudhuri, Ovijit

“…Epithelial cells undergo striking morphological changes during division to ensure proper segregation of genetic and cytoplasmic materials. These morphological…”
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Basal stem cell progeny establish their apical surface in a junctional niche during turnover of an adult barrier epithelium by Galenza, Anthony, Moreno-Roman, Paola, Su, Yu-Han, Acosta-Alvarez, Lehi, Debec, Alain, Guichet, Antoine, Knapp, Jon-Michael, Kizilyaprak, Caroline, Humbel, Bruno M., Kolotuev, Irina, O’Brien, Lucy Erin

“…Barrier epithelial organs face the constant challenge of sealing the interior body from the external environment while simultaneously replacing the cells that…”
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A Model for Adult Organ Resizing Demonstrates Stem Cell Scaling through a Tunable Commitment Rate by Du, XinXin, O’Brien, Lucy Erin, Riedel-Kruse, Ingmar Hans

“…Many adult organs grow or shrink to accommodate different physiological demands. Often, as total cell number changes, stem cell number changes proportionally…”
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Epithelial polarity and tubulogenesis in vitro by Zegers, Mirjam M.P., O'Brien, Lucy E., Yu, Wei, Datta, Anirban, Mostov, Keith E.

“…The most fundamental type of organization of cells in metazoa is that of epithelia, which comprise sheets of adherent cells that divide the organism into…”
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Feedback regulation of steady-state epithelial turnover and organ size by Liang, Jackson, Balachandra, Shruthi, Ngo, Sang, O’Brien, Lucy Erin

“…Steady-state turnover of the Drosophila midgut arises through an intercellular, E-cadherin–EGFR relay that couples the death of individual enterocytes to the…”
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I, myself, move by O'Brien, Lucy

“…This paper addresses the question “what connection is there between our answer to the question of what we are, and the question, what our actions are?” Suppose…”
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Building epithelial architecture: insights from three-dimensional culture models by Mostov, Keith E, O'Brien, Lucy Erin, Zegers, Mirjam M. P

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β1-Integrin Orients Epithelial Polarity via Rac1 and Laminin by Yu, Wei, Datta, Anirban, Leroy, Pascale, O'Brien, Lucy Erin, Mak, Grace, Jou, Tzuu-Shuh, Matlin, Karl S., Mostov, Keith E., Zegers, Mirjam M.P.

“…Epithelial cells polarize and orient polarity in response to cell-cell and cell-matrix adhesion. Although there has been much recent progress in understanding…”
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Hepatocyte growth factor switches orientation of polarity and mode of movement during morphogenesis of multicellular epithelial structures by Yu, Wei, O'Brien, Lucy E, Wang, Fei, Bourne, Henry, Mostov, Keith E, Zegers, Mirjam M P

“…Epithelial cells form monolayers of polarized cells with apical and basolateral surfaces. Madin-Darby canine kidney epithelial cells transiently lose their…”
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Shameful self‐consciousness by O'Brien, Lucy

“…Shame can be occasioned in startlingly different ways. Here are two classic depictions—one in words, one in paint—that stand in contrast with each other. They…”
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Exocyst is involved in cystogenesis and tubulogenesis and acts by modulating synthesis and delivery of basolateral plasma membrane and secretory proteins by Lipschutz, J H, Guo, W, O'Brien, L E, Nguyen, Y H, Novick, P, Mostov, K E

“…Epithelial cyst and tubule formation are critical processes that involve transient, highly choreographed changes in cell polarity. Factors controlling these…”
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Regional Specificity in the Drosophila Midgut: Setting Boundaries with Stem Cells by O’Brien, Lucy Erin

“…Many organs consist of distinct subregions with specialized physiological roles, but how regional boundaries are upheld during cellular renewal is largely…”
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Long-term live imaging of the Drosophila adult midgut reveals real-time dynamics of division, differentiation and loss by Martin, Judy Lisette, Sanders, Erin Nicole, Moreno-Roman, Paola, Jaramillo Koyama, Leslie Ann, Balachandra, Shruthi, Du, XinXin, O'Brien, Lucy Erin

“…Organ renewal is governed by the dynamics of cell division, differentiation and loss. To study these dynamics in real time, we present a platform for extended…”
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