Search Results - "O’Brien, Fergal"

Mechanosignalling in cartilage: an emerging target for the treatment of osteoarthritis by Hodgkinson, Tom, Kelly, Domhnall C., Curtin, Caroline M., O’Brien, Fergal J.

“…Mechanical stimuli have fundamental roles in articular cartilage during health and disease. Chondrocytes respond to the physical properties of the cartilage…”
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Biomaterials & scaffolds for tissue engineering by O'Brien, Fergal J.

“…Every day thousands of surgical procedures are performed to replace or repair tissue that has been damaged through disease or trauma. The developing field of…”
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Chitosan for gene delivery and orthopedic tissue engineering applications by Raftery, Rosanne, O'Brien, Fergal J, Cryan, Sally-Ann

“…Gene therapy involves the introduction of foreign genetic material into cells in order exert a therapeutic effect. The application of gene therapy to the field…”
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Staphylococcal Osteomyelitis: Disease Progression, Treatment Challenges, and Future Directions by Kavanagh, Nicola, Ryan, Emily J, Widaa, Amro, Sexton, Gillian, Fennell, Jerome, O'Rourke, Sadhbh, Cahill, Kevin C, Kearney, Cathal J, O'Brien, Fergal J, Kerrigan, Steven W

“…Osteomyelitis is an inflammatory bone disease that is caused by an infecting microorganism and leads to progressive bone destruction and loss. The most common…”
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The shape and size of hydroxyapatite particles dictate inflammatory responses following implantation by Lebre, Filipa, Sridharan, Rukmani, Sawkins, Michael J., Kelly, Daniel J., O’Brien, Fergal J., Lavelle, Ed C.

“…The extent of regeneration following biomaterial implantation is dependent on the microenvironment surrounding the implant. Since implant composition can have…”
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Material stiffness influences the polarization state, function and migration mode of macrophages by Sridharan, Rukmani, Cavanagh, Brenton, Cameron, Andrew R., Kelly, Daniel J., O'Brien, Fergal J.

“…[Display omitted] Biomaterial implantation is followed by an inflammatory cascade dominated by macrophages, which determine implant acceptance or rejection…”
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Biomaterial based modulation of macrophage polarization: a review and suggested design principles by Sridharan, Rukmani, Cameron, Andrew R., Kelly, Daniel J., Kearney, Cathal J., O’Brien, Fergal J.

“…Macrophages have long been known for their phagocytic capabilities and immune defence; however, their role in healing is being increasingly recognized in…”
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Staphylococcus aureus protein A plays a critical role in mediating bone destruction and bone loss in osteomyelitis by Widaa, Amro, Claro, Tania, Foster, Timothy J, O'Brien, Fergal J, Kerrigan, Steven W

“…Staphylococcus aureus is the most frequent causative organism of osteomyelitis. It is characterised by widespread bone loss and bone destruction. Previously we…”
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Multi-layered collagen-based scaffolds for osteochondral defect repair in rabbits by Levingstone, Tanya J., Thompson, Emmet, Matsiko, Amos, Schepens, Alexander, Gleeson, John P., O’Brien, Fergal J.

“…[Display omitted] Identification of a suitable treatment for osteochondral repair presents a major challenge due to existing limitations and an urgent clinical…”
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A biomimetic multi-layered collagen-based scaffold for osteochondral repair by Levingstone, Tanya J., Matsiko, Amos, Dickson, Glenn R., O’Brien, Fergal J., Gleeson, John P.

“…Cartilage and osteochondral defects pose a significant challenge in orthopedics. Tissue engineering has shown promise as a potential method for the treatment…”
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Scaffold mean pore size influences mesenchymal stem cell chondrogenic differentiation and matrix deposition by Matsiko, Amos, Gleeson, John P, O'Brien, Fergal J

“…Recent investigations into micro-architecture of scaffolds has revealed that mean pore sizes are cell-type specific and influence cellular shape,…”
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Hypoxia-mimicking bioactive glass/collagen glycosaminoglycan composite scaffolds to enhance angiogenesis and bone repair by Quinlan, Elaine, Partap, Sonia, Azevedo, Maria M, Jell, Gavin, Stevens, Molly M, O'Brien, Fergal J

“…Abstract One of the biggest challenges in regenerative medicine is promoting sufficient vascularisation of tissue-engineered constructs. One approach to…”
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The effect of mean pore size on cell attachment, proliferation and migration in collagen–glycosaminoglycan scaffolds for bone tissue engineering by Murphy, Ciara M, Haugh, Matthew G, O'Brien, Fergal J

“…Abstract In the literature there are conflicting reports on the optimal scaffold mean pore size required for successful bone tissue engineering. This study set…”
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Mesenchymal stem cell fate is regulated by the composition and mechanical properties of collagen–glycosaminoglycan scaffolds by Murphy, Ciara M., Matsiko, Amos, Haugh, Matthew G., Gleeson, John P., O’Brien, Fergal J.

“…In stem cell biology, focus has recently turned to the influence of the intrinsic properties of the extracellular matrix (ECM), such as structural, composition…”
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Investigating the interplay between substrate stiffness and ligand chemistry in directing mesenchymal stem cell differentiation within 3D macro-porous substrates by Haugh, Matthew G., Vaughan, Ted J., Madl, Christopher M., Raftery, Rosanne M., McNamara, Laoise M., O'Brien, Fergal J., Heilshorn, Sarah C.

“…Dimensionality can have a profound impact on stiffness-mediated differentiation of mesenchymal stem cells (MSCs). However, while we have begun to understand…”
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The healing of bony defects by cell-free collagen-based scaffolds compared to stem cell-seeded tissue engineered constructs by Lyons, Frank G, Al-Munajjed, Amir A, Kieran, Stephen M, Toner, Mary E, Murphy, Ciara M, Duffy, Garry P, O’Brien, Fergal J

“…Abstract One of the key challenges in tissue engineering is to understand the host response to scaffolds and engineered constructs. We present a study in which…”
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Insoluble elastin reduces collagen scaffold stiffness, improves viscoelastic properties, and induces a contractile phenotype in smooth muscle cells by Ryan, Alan J, O'Brien, Fergal J

“…Abstract Biomaterials with the capacity to innately guide cell behaviour while also displaying suitable mechanical properties remain a challenge in tissue…”
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Advances in Nerve Guidance Conduit-Based Therapeutics for Peripheral Nerve Repair by Lackington, William A, Ryan, Alan J, O’Brien, Fergal J

“…Peripheral nerve injuries have high incidence rates, limited treatment options and poor clinical outcomes, rendering a significant socioeconomic burden. For…”
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Development of a Gene-Activated Scaffold Incorporating Multifunctional Cell-Penetrating Peptides for pSDF-1α Delivery for Enhanced Angiogenesis in Tissue Engineering Applications by Power, Rachael N, Cavanagh, Brenton L, Dixon, James E, Curtin, Caroline M, O'Brien, Fergal J

“…Non-viral gene delivery has become a popular approach in tissue engineering, as it permits the transient delivery of a therapeutic gene, in order to stimulate…”
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Development of collagen–hydroxyapatite scaffolds incorporating PLGA and alginate microparticles for the controlled delivery of rhBMP-2 for bone tissue engineering by Quinlan, Elaine, López-Noriega, Adolfo, Thompson, Emmet, Kelly, Helena M., Cryan, Sally Ann, O'Brien, Fergal J.

“…The spatiotemporally controlled delivery of the pro-osteogenic factor rhBMP-2 would overcome most of the severe secondary effects linked to the products…”
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