Search Results - "O‘Keeffe, Meredith"

Dendritic cell subsets by Macri, Christophe, Pang, Ee Shan, Patton, Timothy, O’Keeffe, Meredith

“…Dendritic cells (DC) are professional antigen presenting cells comprising a variety of subsets, as either resident or migrating cells, in lymphoid and…”
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Human dendritic cell subsets and function in health and disease by O’Keeffe, Meredith, Mok, Wai Hong, Radford, Kristen J.

“…The method of choice for the development of new vaccines is to target distinct dendritic cell subsets with antigen in vivo and to harness their function in…”
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Rapid interferon independent expression of IFITM3 following T cell activation protects cells from influenza virus infection by Bedford, James G, O'Keeffe, Meredith, Reading, Patrick C, Wakim, Linda M

“…Interferon-induced transmembrane protein 3 (IFITM3) is a potent antiviral protein that enhances cellular resistance to a variety of pathogens, including…”
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PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing by Gavin, Amanda L., Huang, Deli, Huber, Christoph, Mårtensson, Annica, Tardif, Virginie, Skog, Patrick D., Blane, Tanya R., Thinnes, Therese C., Osborn, Kent, Chong, Hayley S., Kargaran, Farnaz, Kimm, Phoebe, Zeitjian, Armen, Sielski, Rachel L., Briggs, Megan, Schulz, Sebastian R., Zarpellon, Alessandro, Cravatt, Benjamin, Pang, Ee Shan, Teijaro, John, de la Torre, Juan Carlos, O’Keeffe, Meredith, Hochrein, Hubertus, Damme, Markus, Teyton, Luc, Lawson, Brian R., Nemazee, David

“…The sensing of microbial genetic material by leukocytes often elicits beneficial pro-inflammatory cytokines, but dysregulated responses can cause severe…”
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SIDT2 Transports Extracellular dsRNA into the Cytoplasm for Innate Immune Recognition by Nguyen, Tan A., Smith, Blake R.C., Tate, Michelle D., Belz, Gabrielle T., Barrios, Marilou H., Elgass, Kirstin D., Weisman, Alexandra S., Baker, Paul J., Preston, Simon P., Whitehead, Lachlan, Garnham, Alexandra, Lundie, Rachel J., Smyth, Gordon K., Pellegrini, Marc, O’Keeffe, Meredith, Wicks, Ian P., Masters, Seth L., Hunter, Craig P., Pang, Ken C.

“…Double-stranded RNA (dsRNA) is a common by-product of viral infections and acts as a potent trigger of antiviral immunity. In the nematode C. elegans, sid-1…”
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The Bacterial Peptidoglycan-Sensing Molecules NOD1 and NOD2 Promote CD8 + Thymocyte Selection by Martinic, Marianne M, Caminschi, Irina, O'Keeffe, Meredith, Thinnes, Therese C, Grumont, Raelene, Gerondakis, Steve, McKay, Dianne B, Nemazee, David, Gavin, Amanda L

“…Nucleotide-binding and oligomerization domain (NOD)-like receptors NOD1 and NOD2 are cytosolic innate immune receptors that recognize microbial peptidoglycans…”
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Clonal multi-omics reveals Bcor as a negative regulator of emergency dendritic cell development by Tian, Luyi, Tomei, Sara, Schreuder, Jaring, Weber, Tom S., Amann-Zalcenstein, Daniela, Lin, Dawn S., Tran, Jessica, Audiger, Cindy, Chu, Mathew, Jarratt, Andrew, Willson, Tracy, Hilton, Adrienne, Pang, Ee Shan, Patton, Timothy, Kelly, Madison, Su, Shian, Gouil, Quentin, Diakumis, Peter, Bahlo, Melanie, Sargeant, Toby, Kats, Lev M., Hodgkin, Philip D., O’Keeffe, Meredith, Ng, Ashley P., Ritchie, Matthew E., Naik, Shalin H.

“…Despite advances in single-cell multi-omics, a single stem or progenitor cell can only be tested once. We developed clonal multi-omics, in which daughters of a…”
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FLT3-ligand treatment of humanized mice results in the generation of large numbers of CD141+ and CD1c+ dendritic cells in vivo by Ding, Yitian, Wilkinson, Andrew, Idris, Adi, Fancke, Ben, O'Keeffe, Meredith, Khalil, Dalia, Ju, Xinsheng, Lahoud, Mireille H, Caminschi, Irina, Shortman, Ken, Rodwell, Robyn, Vuckovic, Slavica, Radford, Kristen J

“…We established a humanized mouse model incorporating FLT3-ligand (FLT3-L) administration after hematopoietic cell reconstitution to investigate expansion,…”
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Monitoring Dendritic Cell Activation and Maturation by Macri, Christophe, Fancke, Ben, Radford, Kristen J, O'Keeffe, Meredith

“…Since the 1997 discovery that the first identified human homolog of Drosophila Toll could activate the innate immune system, the innate arm of immunity has…”
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Quantitative Proteomics Reveals Subset-Specific Viral Recognition in Dendritic Cells by Luber, Christian A., Cox, Jürgen, Lauterbach, Henning, Fancke, Ben, Selbach, Matthias, Tschopp, Jurg, Akira, Shizuo, Wiegand, Marian, Hochrein, Hubertus, O'Keeffe, Meredith, Mann, Matthias

“…Dendritic cell (DC) populations consist of multiple subsets that are essential orchestrators of the immune system. Technological limitations have so far…”
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Helminth Infection-Induced Increase in Virtual Memory CD8 T Cells Is Transient, Driven by IL-15, and Absent in Aged Mice by Hussain, Tabinda, Nguyen, Angela, Daunt, Carmel, Thiele, Daniel, Pang, Ee Shan, Li, Jasmine, Zaini, Aidil, O'Keeffe, Meredith, Zaph, Colby, Harris, Nicola L, Quinn, Kylie M, La Gruta, Nicole L

“…CD8 virtual memory T (TVM) cells are Ag-naive CD8 T cells that have undergone partial differentiation in response to common γ-chain cytokines, particularly…”
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DEC-205 is a cell surface receptor for CpG oligonucleotides by Lahoud, Mireille H, Ahmet, Fatma, Zhang, Jian-Guo, Meuter, Simone, Policheni, Antonia N, Kitsoulis, Susie, Lee, Chin-Nien, O’Keeffe, Meredith, Sullivan, Lucy C, Brooks, Andrew G, Berry, Richard, Rossjohn, Jamie, Mintern, Justine D, Vega-Ramos, Javier, Villadangos, Jose A, Nicola, Nicos A, Nussenzweig, Michel C, Stacey, Katryn J, Shortman, Ken, Heath, William R, Caminschi, Irina

“…Synthetic CpG oligonucleotides (ODN) have potent immunostimulatory properties exploited in clinical vaccine trials. How CpG ODN are captured and delivered to…”
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Pharmacological inhibition of TBK1/IKKε blunts immunopathology in a murine model of SARS-CoV-2 infection by Ullah, Tomalika R., Johansen, Matt D., Balka, Katherine R., Ambrose, Rebecca L., Gearing, Linden J., Roest, James, Vivian, Julian P., Sapkota, Sunil, Jayasekara, W. Samantha N., Wenholz, Daniel S., Aldilla, Vina R., Zeng, Jun, Miemczyk, Stefan, Nguyen, Duc H., Hansbro, Nicole G., Venkatraman, Rajan, Kang, Jung Hee, Pang, Ee Shan, Thomas, Belinda J., Alharbi, Arwaf S., Rezwan, Refaya, O’Keeffe, Meredith, Donald, William A., Ellyard, Julia I., Wong, Wilson, Kumar, Naresh, Kile, Benjamin T., Vinuesa, Carola G., Kelly, Graham E., Laczka, Olivier F., Hansbro, Philip M., De Nardo, Dominic, Gantier, Michael P.

“…TANK-binding kinase 1 (TBK1) is a key signalling component in the production of type-I interferons, which have essential antiviral activities, including…”
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M-CSF: a novel plasmacytoid and conventional dendritic cell poietin by Fancke, Ben, Suter, Mark, Hochrein, Hubertus, O’Keeffe, Meredith

“…The critical importance of plasmacytoid dendritic cells (pDCs) in viral infection, autoimmunity, and tolerance has focused major attention on these cells that…”
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Mouse CD8α+ DCs and human BDCA3+ DCs are major producers of IFN-λ in response to poly IC by Lauterbach, Henning, Bathke, Barbara, Gilles, Stefanie, Traidl-Hoffmann, Claudia, Luber, Christian A., Fejer, György, Freudenberg, Marina A., Davey, Gayle M., Vremec, David, Kallies, Axel, Wu, Li, Shortman, Ken, Chaplin, Paul, Suter, Mark, O’Keeffe, Meredith, Hochrein, Hubertus

“…Polyinosinic:polycytidylic acid (poly IC), a double-stranded RNA, is an effective adjuvant in vivo. IFN-λs (also termed IL-28/29) are potent immunomodulatory…”
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Discordance in STING-Induced Activation and Cell Death Between Mouse and Human Dendritic Cell Populations by Pang, Ee Shan, Daraj, Ghazal, Balka, Katherine R, De Nardo, Dominic, Macri, Christophe, Hochrein, Hubertus, Masterman, Kelly-Anne, Tan, Peck S, Shoppee, Angus, Magill, Zoe, Jahan, Nazneen, Bafit, Mariam, Zhan, Yifan, Kile, Benjamin T, Lawlor, Kate E, Radford, Kristen J, Wright, Mark D, O'Keeffe, Meredith

“…Stimulator of Interferon Genes (STING) is a cytosolic sensor of cyclic dinucleotides (CDNs). The activation of dendritic cells (DC) the STING pathway, and…”
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Elucidating the Motif for CpG Oligonucleotide Binding to the Dendritic Cell Receptor DEC-205 Leads to Improved Adjuvants for Liver-Resident Memory by Li, Jessica, Panetta, Fatma, O’Keeffe, Meredith, Leal Rojas, Ingrid M., Radford, Kristen J., Zhang, Jian-Guo, Fernandez-Ruiz, Daniel, Davey, Gayle M., Gully, Benjamin S., Tullett, Kirsteen M., Rossjohn, Jamie, Berry, Richard, Lee, Chin-Nien, Lahoud, Mireille H., Heath, William R., Caminschi, Irina

“…DEC-205 is a cell-surface receptor that transports bound ligands into the endocytic pathway for degradation or release within lysosomal endosomes. This…”
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Dendritic Cell Responses and Function in Malaria by Yap, Xi Zen, Lundie, Rachel J, Beeson, James G, O'Keeffe, Meredith

“…Malaria remains a serious threat to global health. Sustained malaria control and, eventually, eradication will only be achieved with a broadly effective…”
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Type I interferons induce an epigenetically distinct memory B cell subset in chronic viral infection by Cooper, Lucy, Xu, Hui, Polmear, Jack, Kealy, Liam, Szeto, Christopher, Pang, Ee Shan, Gupta, Mansi, Kirn, Alana, Taylor, Justin J, Jackson, Katherine J L, Broomfield, Benjamin J, Nguyen, Angela, Gago da Graça, Catarina, La Gruta, Nicole, Utzschneider, Daniel T, Groom, Joanna R, Martelotto, Luciano, Parish, Ian A, O'Keeffe, Meredith, Scharer, Christopher D, Gras, Stephanie, Good-Jacobson, Kim L

“…Memory B cells (MBCs) are key providers of long-lived immunity against infectious disease, yet in chronic viral infection, they do not produce effective…”
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T Cell Help Amplifies Innate Signals in CD8+ DCs for Optimal CD8+ T Cell Priming by Greyer, Marie, Whitney, Paul G., Stock, Angus T., Davey, Gayle M., Tebartz, Christina, Bachem, Annabell, Mintern, Justine D., Strugnell, Richard A., Turner, Stephen J., Gebhardt, Thomas, O’Keeffe, Meredith, Heath, William R., Bedoui, Sammy

“…DCs often require stimulation from CD4+ T cells to propagate CD8+ T cell responses, but precisely how T cell help optimizes the priming capacity of DCs and why…”
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