Search Results - "O‘Donnell, John C."

Porcine Models of Neurotrauma and Neurological Disorders by O'Donnell, John C, Petrov, Dmitriy

“…The translation of therapeutics from lab to clinic has a dismal record in the fields of neurotrauma and neurological disorders [...]…”
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Neuronal activity and glutamate uptake decrease mitochondrial mobility in astrocytes and position mitochondria near glutamate transporters by Jackson, Joshua G, O'Donnell, John C, Takano, Hajime, Coulter, Douglas A, Robinson, Michael B

“…Within neurons, mitochondria are nonuniformly distributed and are retained at sites of high activity and metabolic demand. Glutamate transport and the…”
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Challenges and demand for modeling disorders of consciousness following traumatic brain injury by O’Donnell, John C., Browne, Kevin D., Kilbaugh, Todd J., Chen, H. Isaac, Whyte, John, Cullen, D. Kacy

“…•Traumatic Disorders of Consciousness (DoC) lack a preclinical model.•The ubiquitous small animal models of TBI cannot produce prolonged…”
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Evolving use of real-world evidence in the regulatory process: a focus on immuno-oncology treatment and outcomes by O'Donnell, John C, Le, T Kim, Dobrin, Radu, Higashi, Mitch, Pereira, Ashley, Wagner, Samuel, Yang, Arvin, Hukkelhoven, Mathias

“…In recent years, regulatory bodies have increasingly recognized the utility of real-world evidence (RWE) for supplementing and supporting clinical trial data…”
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Personalized Medicine and the Role of Health Economics and Outcomes Research: Issues, Applications, Emerging Trends, and Future Research by O’Donnell, John C., PhD, MA

“…Abstract The decade since the completion of the sequencing of the human genome has witnessed significant advances in the incorporation of genomic information…”
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Displacing hexokinase from mitochondrial voltage-dependent anion channel impairs GLT-1-mediated glutamate uptake but does not disrupt interactions between GLT-1 and mitochondrial proteins by Jackson, Joshua G., O'Donnell, John C., Krizman, Elizabeth, Robinson, Michael B.

“…The glutamate transporter GLT‐1 is the major route for the clearance of extracellular glutamate in the forebrain, and most GLT‐1 protein is found in…”
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Tissue Engineering and Biomaterial Strategies to Elicit Endogenous Neuronal Replacement in the Brain by Purvis, Erin M, O'Donnell, John C, Chen, H Isaac, Cullen, D Kacy

“…Neurogenesis in the postnatal mammalian brain is known to occur in the dentate gyrus of the hippocampus and the subventricular zone. These neurogenic niches…”
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In vivo reactivation by oximes of inhibited blood, brain and peripheral tissue cholinesterase activity following exposure to nerve agents in guinea pigs by Shih, Tsung-Ming, Skovira, Jacob W., O’Donnell, John C., McDonough, John H.

“…This study compared the ability of nine oximes (HI-6, HLö7, MMB-4, TMB-4, carboxime, ICD585, ICD692, ICD3805, and 2-PAM) to reactivate in vivo cholinesterase…”
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Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration by Katiyar, Kritika S, Winter, Carla C, Gordián-Vélez, Wisberty J, O'Donnell, John C, Song, Yeri J, Hernandez, Nicole S, Struzyna, Laura A, Cullen, D Kacy

“…Neurotrauma and neurodegenerative disease often result in lasting neurological deficits due to the limited capacity of the central nervous system (CNS) to…”
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Disorders of nomenclature by O'Donnell, John C.

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Health Technology Assessment: Lessons Learned from Around the World—An Overview by O'Donnell, John C., PhD, Pham, Sissi V., PharmD, Pashos, Chris L., PhD, Miller, David W., PhD, Smith, Marilyn Dix, BPharm, PhD

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In vivo microdialysis and electroencephalographic activity in freely moving guinea pigs exposed to organophosphorus nerve agents sarin and VX: analysis of acetylcholine and glutamate by O’Donnell, John C., McDonough, John H., Shih, Tsung-Ming

“…Organophosphorus nerve agents such as sarin (GB) and VX irreversibly inhibit acetylcholinesterase, causing a buildup of acetylcholine (ACh) in synapses and…”
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Treatment with Tertiary Oximes Prevents Seizures and Improves Survival Following Sarin Intoxication by Shih, Tsung-Ming, Skovira, Jacob W., O’Donnell, John C., McDonough, John H.

“…The capability of the tertiary oximes, monoisonitrosoacetone (MINA) and diacetylmonoxime (DAM), to reactivate acetylcholinesterase (AChE) inhibited by sarin…”
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Transient Oxygen/Glucose Deprivation Causes a Delayed Loss of Mitochondria and Increases Spontaneous Calcium Signaling in Astrocytic Processes by O'Donnell, John C, Jackson, Joshua G, Robinson, Michael B

“…Recently, mitochondria have been localized to astrocytic processes where they shape Ca(2+) signaling; this relationship has not been examined in models of…”
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Co-compartmentalization of the astroglial glutamate transporter, GLT-1, with glycolytic enzymes and mitochondria by Genda, Elizabeth N, Jackson, Joshua G, Sheldon, Amanda L, Locke, Susannah F, Greco, Todd M, O'Donnell, John C, Spruce, Lynn A, Xiao, Rui, Guo, Wensheng, Putt, Mary, Seeholzer, Steven, Ischiropoulos, Harry, Robinson, Michael B

“…Efficient excitatory transmission depends on a family of transporters that use the Na(+)-electrochemical gradient to maintain low synaptic concentrations of…”
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Porcine Astrocytes and Their Relevance for Translational Neurotrauma Research by Purvis, Erin M, Fedorczak, Natalia, Prah, Annette, Han, Daniel, O’Donnell, John C

“…Astrocytes are essential to virtually all brain processes, from ion homeostasis to neurovascular coupling to metabolism, and even play an active role in…”
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A tissue-engineered rostral migratory stream for directed neuronal replacement by O'Donnell, John, Katiyar, Kritika, Panzer, Kate, Cullen, D

“…New neurons are integrated into the circuitry of the olfactory bulb throughout the lifespan in the mammalian brain-including in humans. These new neurons are…”
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Porcine Models of Spinal Cord Injury by Wathen, Connor A, Ghenbot, Yohannes G, Ozturk, Ali K, Cullen, D Kacy, O'Donnell, John C, Petrov, Dmitriy

“…Large animal models of spinal cord injury may be useful tools in facilitating the development of translational therapies for spinal cord injury (SCI). Porcine…”
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Multimodal Neuromonitoring and Neurocritical Care in Swine to Enhance Translational Relevance in Brain Trauma Research by O'Donnell, John C, Browne, Kevin D, Kvint, Svetlana, Makaron, Leah, Grovola, Michael R, Karandikar, Saarang, Kilbaugh, Todd J, Cullen, D Kacy, Petrov, Dmitriy

“…Neurocritical care significantly impacts outcomes after moderate-to-severe acquired brain injury, but it is rarely applied in preclinical studies. We created a…”
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Bedside to bench: the outlook for psychedelic research by Acero, Victor P, Cribas, Emily S, Browne, Kevin D, Rivellini, Olivia, Burrell, Justin C, O'Donnell, John C, Das, Suradip, Cullen, D Kacy

“…There has recently been a resurgence of interest in psychedelic compounds based on studies demonstrating their potential therapeutic applications in treating…”
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