Search Results - "O‘Brien, Mary"
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Systemic therapy of advanced non-small cell lung cancer: Major-developments of the last 5-years
Published in European journal of cancer (1990) (01-04-2013)“…Abstract The standard palliative treatment for advanced stage NSCLC remains a platinum doublet but by tailoring chemotherapy according to tumour histology the…”
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A review of computer vision-based approaches for physical rehabilitation and assessment
Published in Multimedia systems (01-02-2022)“…The computer vision community has extensively researched the area of human motion analysis, which primarily focuses on pose estimation, activity recognition,…”
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Adjuvant Erlotinib Versus Placebo in Patients With Stage IB-IIIA Non-Small-Cell Lung Cancer (RADIANT): A Randomized, Double-Blind, Phase III Trial
Published in Journal of clinical oncology (01-12-2015)“…Epidermal growth factor receptor (EGFR) -tyrosine kinase inhibitors have proven efficacy in advanced non-small-cell lung cancer (NSCLC). We hypothesized that…”
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Local opinion leaders: effects on professional practice and healthcare outcomes
Published in Cochrane database of systematic reviews (24-06-2019)“…Clinical practice is not always evidence-based and, therefore, may not optimise patient outcomes. Local opinion leaders (OLs) are individuals perceived as…”
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Randomized phase III trial of amrubicin versus topotecan as second-line treatment for patients with small-cell lung cancer
Published in Journal of clinical oncology (10-12-2014)“…Amrubicin, a third-generation anthracycline and potent topoisomerase II inhibitor, showed promising activity in small-cell lung cancer (SCLC) in phase II…”
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Healthcare professionals' perceptions of pulmonary rehabilitation as a management strategy for patients with chronic obstructive pulmonary disease: a critical interpretive synthesis
Published in Disability and rehabilitation (13-02-2022)“…To establish literature regarding healthcare professionals' perceptions of pulmonary rehabilitation as a management strategy for patients with chronic…”
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Factors that enable effective One Health collaborations - A scoping review of the literature
Published in PloS one (04-12-2019)“…Advocates for a One Health approach recognize that global health challenges require multidisciplinary collaborative efforts. While past publications have…”
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Phase III Trial Comparing Supportive Care Alone With Supportive Care With Oral Topotecan in Patients With Relapsed Small-Cell Lung Cancer
Published in Journal of clinical oncology (01-12-2006)“…For patients with small-cell lung cancer (SCLC), further chemotherapy is routinely considered at relapse after first-line therapy. However, proof of clinical…”
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The use of digital legacies with people affected by motor neurone disease for continuing bonds: An interpretative phenomenological analysis study
Published in Palliative medicine (01-07-2019)“…Background: Motor neurone disease is a progressive neurodegenerative disease without cure. Little is known about how young people are affected when a family…”
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The engagement of young people in their own advance care planning process: A systematic narrative synthesis
Published in Palliative Medicine (01-07-2018)“…Background: An increasing number of young people are living with life-limiting conditions. Current research about advance care planning for young people…”
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Views and experiences of young people, their parents/carers and healthcare professionals of the advance care planning process: A summary of the findings from a qualitative study
Published in Palliative medicine (01-05-2022)“…Background: Advance care planning for young people is relatively new in the UK. There is a lack of understanding about the engagement of young people in their…”
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Splenic volume as a predictor of treatment response in patients with non-small cell lung cancer receiving immunotherapy
Published in PloS one (07-07-2022)“…Introduction The spleen is a lymphoid organ and we hypothesize that clinical benefit to immunotherapy may present with an increase in splenic volume during…”
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Meeting patients’ spiritual needs during end‐of‐life care: A qualitative study of nurses’ and healthcare professionals’ perceptions of spiritual care training
Published in Journal of clinical nursing (01-01-2019)“…Aims and objectives To explore nurses’ and healthcare professionals’ perceptions of spiritual care and the impact of spiritual care training on their clinical…”
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Six versus fewer planned cycles of first-line platinum-based chemotherapy for non-small-cell lung cancer: a systematic review and meta-analysis of individual patient data
Published in The lancet oncology (01-10-2014)“…Summary Background Platinum-based chemotherapy is the standard first-line treatment for patients with advanced non-small-cell lung cancer. However, the optimum…”
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Phase II study of first-line bortezomib and cisplatin in malignant pleural mesothelioma and prospective validation of progression free survival rate as a primary end-point for mesothelioma clinical trials (European Organisation for Research and Treatment of Cancer 08052)
Published in European journal of cancer (1990) (01-09-2013)“…Abstract Background This was a prospective phase II study of cisplatin and bortezomib (CB) in the first line treatment of malignant pleural mesothelioma (MPM)…”
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A Randomized Clinical Trial to Dismantle Components of Cognitive Processing Therapy for Posttraumatic Stress Disorder in Female Victims of Interpersonal Violence
Published in Journal of consulting and clinical psychology (01-04-2008)“…The purpose of this experiment was to conduct a dismantling study of cognitive processing therapy in which the full protocol was compared with its constituent…”
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Maintenance pazopanib versus placebo in Non-Small Cell Lung Cancer patients non-progressive after first line chemotherapy: A double blind randomised phase III study of the lung cancer group, EORTC 08092 (EudraCT: 2010-018566-23, NCT01208064)
Published in European journal of cancer (1990) (01-08-2015)“…Abstract Background Switch maintenance is an effective strategy in the treatment of advanced Non-Small Cell Lung Cancer (NSCLC). Pazopanib is an oral,…”
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Differences in Signaling Patterns on PI3K Inhibition Reveal Context Specificity in KRAS -Mutant Cancers
Published in Molecular cancer therapeutics (01-08-2019)“…It is increasingly appreciated that drug response to different cancers driven by the same oncogene is different and may relate to differences in rewiring of…”
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Concurrent once-daily versus twice-daily chemoradiotherapy in patients with limited-stage small-cell lung cancer (CONVERT): an open-label, phase 3, randomised, superiority trial
Published in The lancet oncology (01-08-2017)“…Summary Background Concurrent chemoradiotherapy is the standard of care in limited-stage small-cell lung cancer, but the optimal radiotherapy schedule and dose…”
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Overcoming CYP1A1/1A2 Mediated Induction of Metabolism by Escalating Erlotinib Dose in Current Smokers
Published in Journal of clinical oncology (10-03-2009)“…Cigarette smoking induces CYP1A1/1A2 and is hypothesized to alter erlotinib pharmacokinetics. This study aimed to determine the maximum tolerated dose (MTD) of…”
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