Search Results - "OʼNeil, Roger G"

Heteromeric TRPV4-C1 channels contribute to store-operated Ca2+ entry in vascular endothelial cells by Ma, Xin, Cheng, Kwong-Tai, Wong, Ching-On, O’Neil, Roger G, Birnbaumer, Lutz, Ambudkar, Indu S, Yao, Xiaoqiang

“…Abstract There is controversy as to whether TRP channels participate in mediating store-operated current (ISOC ) and store-operated Ca2+ entry (SOCE). Our…”
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Tight junction protein expression and barrier properties of immortalized mouse brain microvessel endothelial cells by Brown, Rachel C, Morris, Andrew P, O'Neil, Roger G

“…Abstract Understanding the molecular and biochemical mechanisms regulating the blood–brain barrier is aided by in vitro model systems. Many studies have used…”
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Transient receptor potential vanilloid 4–expressing macrophages and keratinocytes contribute differentially to allergic and nonallergic chronic itch by Luo, Jialie, Feng, Jing, Yu, Guang, Yang, Pu, Mack, Madison R., Du, Junhui, Yu, Weihua, Qian, Aihua, Zhang, Yujin, Liu, Shenbin, Yin, Shijin, Xu, Amy, Cheng, Jizhong, Liu, Qingyun, O'Neil, Roger G., Xia, Yang, Ma, Liang, Carlton, Susan M., Kim, Brian S., Renner, Kenneth, Liu, Qin, Hu, Hongzhen

“…Chronic itch is a highly debilitating symptom that underlies many medical disorders with no universally effective treatments. Although unique neuronal…”
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TRPV1 channels make major contributions to behavioral hypersensitivity and spontaneous activity in nociceptors after spinal cord injury by Wu, Zizhen, Yang, Qing, Crook, Robyn J., O’Neil, Roger G., Walters, Edgar T.

“…SCI increases TRPV1 in DRG neurons and enhances sensitivity of nociceptors to capsaicin. TRPV1 maintains behavioral hypersensitivity after SCI and promotes…”
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Critical role of TRPP2 and TRPC1 channels in stretch-induced injury of blood–brain barrier endothelial cells by Berrout, Jonathan, Jin, Min, O'Neil, Roger G

“…Abstract The microvessels of the brain are very sensitive to mechanical stresses such as observed in traumatic brain injury (TBI). Such stresses can quickly…”
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The mechanosensitive nature of TRPV channels by O'Neil, Roger G, Heller, Stefan

“…Transient receptor potential vanilloid (TRPV) channels are widely expressed in both sensory and nonsensory cells. Whereas the channels display a broad…”
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Function of Transient Receptor Potential Cation Channel Subfamily V Member 4 (TRPV4) as a Mechanical Transducer in Flow-sensitive Segments of Renal Collecting Duct System by Berrout, Jonathan, Jin, Min, Mamenko, Mykola, Zaika, Oleg, Pochynyuk, Oleh, O'Neil, Roger G.

“…The TRPV4 Ca2+-permeable channel is sensitive to mechanical stimuli. In the current study we have employed immunocytochemical staining in kidney slices and…”
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The renal TRPV4 channel is essential for adaptation to increased dietary potassium by Mamenko, Mykola V, Boukelmoune, Nabila, Tomilin, Viktor N, Zaika, Oleg L, Jensen, V Behrana, O'Neil, Roger G, Pochynyuk, Oleh M

“…To maintain potassium homeostasis, kidneys exert flow-dependent potassium secretion to facilitate kaliuresis in response to elevated dietary potassium intake…”
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Expression of a Diverse Array of Ca2+-Activated K+ Channels (SK1/3, IK1, BK) that Functionally Couple to the Mechanosensitive TRPV4 Channel in the Collecting Duct System of Kidney by Li, Yue, Hu, Hongxiang, Butterworth, Michael B, Tian, Jin-Bin, Zhu, Michael X, O'Neil, Roger G

“…The voltage- and Ca2+-activated, large conductance K+ channel (BK, maxi-K) is expressed in the collecting duct system of kidney where it underlies flow- and…”
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Insight into NSAID-induced membrane alterations, pathogenesis and therapeutics: Characterization of interaction of NSAIDs with phosphatidylcholine by Lichtenberger, Lenard M., Zhou, Yong, Jayaraman, Vasanthi, Doyen, Janice R., O'Neil, Roger G., Dial, Elizabeth J., Volk, David E., Gorenstein, David G., Boggara, Mohan Babu, Krishnamoorti, Ramanan

“…Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most widely consumed pharmaceuticals, yet both the mechanisms involved in their therapeutic…”
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Novel insights into TRPV4 function in the kidney by Pochynyuk, Oleh, Zaika, Oleg, O’Neil, Roger G., Mamenko, Mykola

“…Kidneys are complex highly organized paired organs of nearly one million nephrons each. They rigorously process about 180 l of plasma daily to keep whole body…”
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Determinants of TRPV4 activity following selective activation by small molecule agonist GSK1016790A by Jin, Min, Wu, Zizhen, Chen, Ling, Jaimes, Jose, Collins, Diana, Walters, Edgar T, O'Neil, Roger G

“…TRPV4 (Transient Receptor Potential Vanilloid 4) channels are activated by a wide range of stimuli, including hypotonic stress, non-noxious heat and mechanical…”
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TRPV4 Dysfunction Promotes Renal Cystogenesis in Autosomal Recessive Polycystic Kidney Disease by ZAIKA, Oleg, MAMENKO, Mykola, BERROUT, Jonathan, BOUKELMOUNE, Nabila, O'NEIL, Roger G, POCHYNYUK, Oleh

“…The molecular mechanism of cyst formation and expansion in autosomal recessive polycystic kidney disease (ARPKD) is poorly understood, but impaired…”
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Dual role of the TRPV4 channel as a sensor of flow and osmolality in renal epithelial cells by Wu, Ling, Gao, Xiaochong, Brown, Rachel C, Heller, Stefan, O'Neil, Roger G

“…Gain/loss of function studies were utilized to assess the potential role of the endogenous vanilloid receptor TRPV4 as a sensor of flow and osmolality in M-1…”
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Hypotonicity-induced TRPV4 function in renal collecting duct cells: modulation by progressive cross-talk with Ca2+ -activated K+ channels by Jin, Min, Berrout, Jonathan, Chen, Ling, O’Neil, Roger G

“…Abstract The mouse cortical collecting duct (CCD) M-1 cells were grown to confluency on coverslips to assess the interaction between TRPV4 and Ca2+ -activated…”
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Discrete Control of TRPV4 Channel Function in the Distal Nephron by Protein Kinases A and C by Mamenko, Mykola, Zaika, Oleg L., Boukelmoune, Nabila, Berrout, Jonathan, O'Neil, Roger G., Pochynyuk, Oleh

“…We have recently documented that the Ca2+-permeable TRPV4 channel, which is abundantly expressed in distal nephron cells, mediates cellular Ca2+ responses to…”
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Competition between Grb2 and Plcγ1 for FGFR2 regulates basal phospholipase activity and invasion by Timsah, Zahra, Ahmed, Zamal, Lin, Chi-Chuan, Melo, Fernando A, Stagg, Loren J, Leonard, Paul G, Jeyabal, Prince, Berrout, Jonathan, O'Neil, Roger G, Bogdanov, Mikhail, Ladbury, John E

“…Cancer cells often exhibit hyperactive signaling pathways. A new study now shows that Plcγ1 competes with Grb2 for binding to the fibroblast growth factor…”
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Uptake of a fluorescent deoxyglucose analog (2-NBDG) in tumor cells by O'Neil, Roger G, Wu, Ling, Mullani, Nizar

“…A new fluorescent analog of D -glucose was recently developed by [Yoshioka K, Takahashi H, Homma T, Sato M, Ki Bong O, Nemoto Y, Matsuoka H (1996) A novel…”
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Bradykinin acutely inhibits activity of the epithelial Na+ channel in mammalian aldosterone-sensitive distal nephron by Zaika, Oleg, Mamenko, Mykola, O'Neil, Roger G, Pochynyuk, Oleh

“…Activation of the renal kallikrein-kinin system results in natriuresis and diuresis, suggesting its possible role in renal tubular sodium transport regulation…”
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Purinergic activation of Ca2+-permeable TRPV4 channels is essential for mechano-sensitivity in the aldosterone-sensitive distal nephron by Mamenko, Mykola, Zaika, Oleg, Jin, Min, O'Neil, Roger G, Pochynyuk, Oleh

“…Mechanical forces are known to induce increases of [Ca(2+)](i) in the aldosterone-sensitive distal nephron (ASDN) cells to regulate epithelial transport. At…”
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