Search Results - "OʼHagan, Derek T"

Emerging concepts in the science of vaccine adjuvants by Pulendran, Bali, S. Arunachalam, Prabhu, O’Hagan, Derek T.

“…Adjuvants are vaccine components that enhance the magnitude, breadth and durability of the immune response. Following its introduction in the 1920s, alum…”
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Lipid-Based Nanoparticles for Delivery of Vaccine Adjuvants and Antigens: Toward Multicomponent Vaccines by Chatzikleanthous, Despo, O’Hagan, Derek T, Adamo, Roberto

“…Despite the many advances that have occurred in the field of vaccine adjuvants, there are still unmet needs that may enable the development of vaccines…”
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Optimizing the utilization of aluminum adjuvants in vaccines: you might just get what you want by HogenEsch, Harm, O’Hagan, Derek T., Fox, Christopher B.

“…Aluminum-containing adjuvants have been used for over 90 years to enhance the immune response to vaccines. Recent work has significantly advanced our…”
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New generation adjuvants – From empiricism to rational design by O’Hagan, Derek T, Fox, Christopher B

“…Abstract Adjuvants are an essential component of modern vaccine development. Despite many decades of development, only a few types of adjuvants are currently…”
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Aluminum Adjuvants-'Back to the Future' by Laera, Donatello, HogenEsch, Harm, O'Hagan, Derek T

“…Aluminum-based adjuvants will continue to be a key component of currently approved and next generation vaccines, including important combination vaccines. The…”
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The continued advance of vaccine adjuvants – ‘we can work it out’ by O’Hagan, Derek T., Lodaya, Rushit N., Lofano, Giuseppe

“…•Key technological advances have enabled the development and licensing of vaccines containing new adjuvants.•Understanding the mechanisms of action of…”
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Mechanism of action of mRNA-based vaccines by Iavarone, Carlo, O'hagan, Derek T, Yu, Dong, Delahaye, Nicolas F, Ulmer, Jeffrey B

“…The present review summarizes the growing body of work defining the mechanisms of action of this exciting new vaccine technology that should allow rational…”
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Nonviral delivery of self-amplifying RNA vaccines by Geall, Andrew J, Verma, Ayush, Otten, Gillis R, Shaw, Christine A, Hekele, Armin, Banerjee, Kaustuv, Cu, Yen, Beard, Clayton W, Brito, Luis A, Krucker, Thomas, O’Hagan, Derek T, Singh, Manmohan, Mason, Peter W, Valiante, Nicholas M, Dormitzer, Philip R, Barnett, Susan W, Rappuoli, Rino, Ulmer, Jeffrey B, Mandl, Christian W

“…Despite more than two decades of research and development on nucleic acid vaccines, there is still no commercial product for human use. Taking advantage of the…”
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Vaccine adjuvant formulations: A pharmaceutical perspective by Brito, Luis A, Malyala, Padma, O’Hagan, Derek T

“…Highlights • Formulation science is unappreciated and often overlooked in vaccinology. • Vaccine formulations should be stable, reproducible, robust and…”
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Vaccine adjuvants alum and MF59 induce rapid recruitment of neutrophils and monocytes that participate in antigen transport to draining lymph nodes by Calabro, Samuele, Tortoli, Marco, Baudner, Barbara C, Pacitto, Alessandra, Cortese, Mario, O’Hagan, Derek T, De Gregorio, Ennio, Seubert, Anja, Wack, Andreas

“…Abstract Vaccine adjuvants such as alum and the oil-in-water emulsion MF59 are used to enhance immune responses towards pure soluble antigens, but their…”
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The Adjuvants Aluminum Hydroxide and MF59 Induce Monocyte and Granulocyte Chemoattractants and Enhance Monocyte Differentiation toward Dendritic Cells by Seubert, Anja, Monaci, Elisabetta, Pizza, Mariagrazia, O'Hagan, Derek T, Wack, Andreas

“…Aluminum hydroxide (alum) and the oil-in-water emulsion MF59 are widely used, safe and effective adjuvants, yet their mechanism of action is poorly understood…”
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Towards an evidence based approach for the development of adjuvanted vaccines by O’Hagan, Derek T, Friedland, Leonard R, Hanon, Emmanuel, Didierlaurent, Arnaud M

“…•New adjuvants are typically a combination of delivery system and an immune potentiator.•A deeper understanding of innate immunity has helped the discovery of…”
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The adjuvant effect of MF59 is due to the oil-in-water emulsion formulation, none of the individual components induce a comparable adjuvant effect by Calabro, Samuele, Tritto, Elaine, Pezzotti, Annamaria, Taccone, Marianna, Muzzi, Alessandro, Bertholet, Sylvie, De Gregorio, Ennio, O’Hagan, Derek T, Baudner, Barbara, Seubert, Anja

“…Highlights • We dissect the mechanism of MF59, an adjuvant used in human vaccines. • We set to identify its putative adjuvant-active ingredient(s). • Span85…”
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“World in motion” – emulsion adjuvants rising to meet the pandemic challenges by O’Hagan, Derek T., van der Most, Robbert, Lodaya, Rushit N., Coccia, Margherita, Lofano, Giuseppe

“…Emulsion adjuvants such as MF59 and AS03 have been used for more than two decades as key components of licensed vaccines, with over 100 million doses…”
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Vaccine priming is restricted to draining lymph nodes and controlled by adjuvant-mediated antigen uptake by Liang, Frank, Lindgren, Gustaf, Sandgren, Kerrie J, Thompson, Elizabeth A, Francica, Joseph R, Seubert, Anja, De Gregorio, Ennio, Barnett, Susan, O'Hagan, Derek T, Sullivan, Nancy J, Koup, Richard A, Seder, Robert A, Loré, Karin

“…The innate immune mechanisms by which adjuvants enhance the potency and protection of vaccine-induced adaptive immunity are largely unknown. We introduce a…”
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The path to a successful vaccine adjuvant – ‘The long and winding road’ by O’Hagan, Derek T., De Gregorio, Ennio

“…New generation vaccines will increasingly comprise highly purified recombinant proteins. Unfortunately, these antigens are often poorly immunogenic. Therefore,…”
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Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines by Walls, Alexandra C., Miranda, Marcos C., Schäfer, Alexandra, Pham, Minh N., Greaney, Allison, Arunachalam, Prabhu S., Navarro, Mary-Jane, Tortorici, M. Alejandra, Rogers, Kenneth, O’Connor, Megan A., Shirreff, Lisa, Ferrell, Douglas E., Bowen, John, Brunette, Natalie, Kepl, Elizabeth, Zepeda, Samantha K., Starr, Tyler, Hsieh, Ching-Lin, Fiala, Brooke, Wrenn, Samuel, Pettie, Deleah, Sydeman, Claire, Sprouse, Kaitlin R., Johnson, Max, Blackstone, Alyssa, Ravichandran, Rashmi, Ogohara, Cassandra, Carter, Lauren, Tilles, Sasha W., Rappuoli, Rino, Leist, Sarah R., Martinez, David R., Clark, Matthew, Tisch, Roland, O’Hagan, Derek T., Van Der Most, Robbert, Van Voorhis, Wesley C., Corti, Davide, McLellan, Jason S., Kleanthous, Harry, Sheahan, Timothy P., Smith, Kelly D., Fuller, Deborah H., Villinger, Francois, Bloom, Jesse, Pulendran, Bali, Baric, Ralph S., King, Neil P., Veesler, David

“…Understanding vaccine-elicited protection against SARS-CoV-2 variants and other sarbecoviruses is key for guiding public health policies. We show that a…”
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Vaccine composition formulated with a novel TLR7-dependent adjuvant induces high and broad protection against Staphylococcus aureus by Bagnoli, Fabio, Fontana, Maria Rita, Soldaini, Elisabetta, Mishra, Ravi P N, Fiaschi, Luigi, Cartocci, Elena, Nardi-Dei, Vincenzo, Ruggiero, Paolo, Nosari, Sarah, De Falco, Maria Grazia, Lofano, Giuseppe, Marchi, Sara, Galletti, Bruno, Mariotti, Paolo, Bacconi, Marta, Torre, Antonina, Maccari, Silvia, Scarselli, Maria, Rinaudo, C Daniela, Inoshima, Naoko, Savino, Silvana, Mori, Elena, Rossi-Paccani, Silvia, Baudner, Barbara, Pallaoro, Michele, Swennen, Erwin, Petracca, Roberto, Brettoni, Cecilia, Liberatori, Sabrina, Norais, Nathalie, Monaci, Elisabetta, Bubeck Wardenburg, Juliane, Schneewind, Olaf, O'Hagan, Derek T, Valiante, Nicholas M, Bensi, Giuliano, Bertholet, Sylvie, De Gregorio, Ennio, Rappuoli, Rino, Grandi, Guido

“…Significance Staphylococcus aureus is a human pathogen causing life-threatening infections. The high incidence of methicillin-resistant S. aureus isolates…”
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Mannosylation of LNP Results in Improved Potency for Self-Amplifying RNA (SAM) Vaccines by Goswami, Roshan, Chatzikleanthous, Despo, Lou, Gustavo, Giusti, Fabiola, Bonci, Alessandra, Taccone, Marianna, Brazzoli, Michela, Gallorini, Simona, Ferlenghi, Ilaria, Berti, Francesco, O’Hagan, Derek T, Pergola, Carlo, Baudner, Barbara C, Adamo, Roberto

“…Mannosylation of Lipid Nanoparticles (LNP) can potentially enhance uptake by Antigen Presenting Cells, which are highly abundant in dermal tissues, to improve…”
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The droplet size of emulsion adjuvants has significant impact on their potency, due to differences in immune cell-recruitment and -activation by Shah, Ruchi R., Taccone, Marianna, Monaci, Elisabetta, Brito, Luis A., Bonci, Alessandra, O’Hagan, Derek T., Amiji, Mansoor M., Seubert, Anja

“…Self-emulsification is routinely used for oral delivery of lipophilic drugs in vivo , with the emulsion forming in vivo . We modified this technique to prepare…”
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