Search Results - "OʼConnor, Daniel T"

Human dopamine beta-hydroxylase (DBH) regulatory polymorphism that influences enzymatic activity, autonomic function, and blood pressure by Chen, Yuqing, Wen, Gen, Rao, Fangwen, Zhang, Kuixing, Wang, Lei, Rodriguez-Flores, Juan L, Sanchez, Amber P, Mahata, Manjula, Taupenot, Laurent, Sun, Ping, Mahata, Sushil K, Tayo, Bamidele, Schork, Nicholas J, Ziegler, Michael G, Hamilton, Bruce A, OʼConnor, Daniel T

“…RATIONALEDopamine beta-hydroxylase (DBH) plays an essential role in catecholamine synthesis by converting dopamine into norepinephrine. Here we systematically…”
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C-reactive protein, an ‘intermediate phenotype’ for inflammation: human twin studies reveal heritability, association with blood pressure and the metabolic syndrome, and the influence of common polymorphism at catecholaminergic/β-adrenergic pathway loci by Wessel, Jennifer, Moratorio, Guillermo, Rao, Fangwen, Mahata, Manjula, Zhang, Lian, Greene, William, Rana, Brinda K, Kennedy, Brian P, Khandrika, Srikrishna, Huang, Pauline, Lillie, Elizabeth O, Shih, Pei-An Betty, Smith, Douglas W, Wen, Gen, Hamilton, Bruce A, Ziegler, Michael G, Witztum, Joseph L, Schork, Nicholas J, Schmid-Schönbein, Geert W, OʼConnor, Daniel T

“…BACKGROUNDC-reactive protein (CRP) both reflects and participates in inflammation, and its circulating concentration marks cardiovascular risk. Here we sought…”
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Assessment of plasma C-reactive protein as a biomarker of posttraumatic stress disorder risk by Eraly, Satish A, Nievergelt, Caroline M, Maihofer, Adam X, Barkauskas, Donald A, Biswas, Nilima, Agorastos, Agorastos, O'Connor, Daniel T, Baker, Dewleen G

“…Posttraumatic stress disorder (PTSD) has been associated in cross-sectional studies with peripheral inflammation. It is not known whether this observed…”
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Effects of chromogranin A deficiency and excess in vivo: biphasic blood pressure and catecholamine responses by Vaingankar, Sucheta M, Li, Ying, Biswas, Nilima, Gayen, Jiaur, Choksi, Sonia, Rao, Fangwen, Ziegler, Michael G, Mahata, Sushil K, OʼConnor, Daniel T

“…OBJECTIVEThe phenotype of the chromogranin A (Chga) null (knockout) mouse is hypertensive. However, hypertensive humans and spontaneously hypertensive rats…”
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Autonomic Function in Hypertension: Role of Genetic Variation at the Catecholamine Storage Vesicle Protein Chromogranin B by Zhang, Kuixing, Rao, Fangwen, Rana, Brinda K, Gayen, Jiaur R, Calegari, Federico, King, Angus, Rosa, Patrizia, Huttner, Wieland B, Stridsberg, Mats, Mahata, Manjula, Vaingankar, Sucheta, Mahboubi, Vafa, Salem, Rany M, Rodriguez-Flores, Juan L, Fung, Maple M, Smith, Douglas W, Schork, Nicholas J, Ziegler, Michael G, Taupenot, Laurent, Mahata, Sushil K, O'Connor, Daniel T

“…Autonomic Function in Hypertension Role of Genetic Variation at the Catecholamine Storage Vesicle Protein Chromogranin B Kuixing Zhang, MD, PhD ; Fangwen Rao,…”
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Peptide YY (PYY) Gene Polymorphisms in the 3′-Untranslated and Proximal Promoter Regions Regulate Cellular Gene Expression and PYY Secretion and Metabolic Syndrome Traits in Vivo by Shih, Pei-an Betty, Wang, Lei, Chiron, Stephane, Wen, Gen, Nievergelt, Caroline, Mahata, Manjula, Khandrika, Srikrishna, Rao, Fangwen, Fung, Maple M., Mahata, Sushil K., Hamilton, Bruce A., O'Connor, Daniel T.

“…Rationale: Obesity is a heritable trait that contributes to hypertension and subsequent cardiorenal disease risk; thus, the investigation of genetic variation…”
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Genomic predictors of combat stress vulnerability and resilience in U.S. Marines: A genome-wide association study across multiple ancestries implicates PRTFDC1 as a potential PTSD gene by Nievergelt, Caroline M, Maihofer, Adam X, Mustapic, Maja, Yurgil, Kate A, Schork, Nicholas J, Miller, Mark W, Logue, Mark W, Geyer, Mark A, Risbrough, Victoria B, O’Connor, Daniel T, Baker, Dewleen G

“…Highlights • We performed a GWAS in a large cohort of trauma-exposed U.S. Marines. • A meta-analysis across multiple ancestries was performed. • We identified…”
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Heart rate variability characteristics in a large group of active-duty marines and relationship to posttraumatic stress by Minassian, Arpi, Geyer, Mark A, Baker, Dewleen G, Nievergelt, Caroline M, O'Connor, Daniel T, Risbrough, Victoria B

“…Heart rate variability (HRV), thought to reflect autonomic nervous system function, is lowered under conditions such as posttraumatic stress disorder (PTSD)…”
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Chromogranin A pathway: from pathogenic molecule to renal disease by Mir, Saiful A., Biswas, Nilima, Cheung, Wai, Wan, Ji, Webster, Nicholas, Macedo, Etienne, O’Connor, Daniel T., Vaingankar, Sucheta M.

“…BACKGROUND:Chromogranin A (CHGA) is an index granin protein critical for biogenesis and exocytotic release of catecholamine storage granules. It is elevated in…”
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Heritability of Biomarkers of Oxidized Lipoproteins: Twin Pair Study by Rao, Fangwen, Schork, Andrew J, Maihofer, Adam X, Nievergelt, Caroline M, Marcovina, Santica M, Miller, Elizabeth R, Witztum, Joseph L, O’Connor, Daniel T, Tsimikas, Sotirios

“…OBJECTIVE—To determine whether biomarkers of oxidized lipoproteins are genetically determined. Lipoprotein(a) (Lp[a]) is a heritable risk factor and carrier of…”
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Report of the National Heart, Lung, and Blood Institute Working Group on Epigenetics and Hypertension by Cowley, Allen W, Nadeau, Joseph H, Baccarelli, Andrea, Berecek, Kathleen, Fornage, Myriam, Gibbons, Gary H, Harrison, David G, Liang, Mingyu, Nathanielsz, Peter W, OʼConnor, Daniel T, Ordovas, Jose, Peng, Weiqun, Soares, Marcelo Bento, Szyf, Moshe, Tolunay, H Eser, Wood, Katherine C, Zhao, Keji, Galis, Zorina S

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Catestatin: A multifunctional peptide from chromogranin A by Mahata, Sushil K., Mahata, Manjula, Fung, Maple M., O'Connor, Daniel T.

“…In 1997, we identified a novel peptide, catestatin (CST: bovine chromogranin A [CHGA] 344–364: RSMRLSFRARGYGFRGPGLQL; human CHGA 352–372:…”
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Newer Technologies in Breast Cancer Imaging: Dedicated Cone-Beam Breast Computed Tomography by O’Connell, Avice M., Karellas, Andrew, Vedantham, Srinivasan, Kawakyu-O’Connor, Daniel T.

“…Dedicated breast computed tomography (CT) is the latest in a long history of breast imaging techniques dating back to the 1960s. Breast imaging is performed…”
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Pancreastatin-dependent inflammatory signaling mediates obesity-induced insulin resistance by Bandyopadhyay, Gautam K, Lu, Minh, Avolio, Ennio, Siddiqui, Jawed A, Gayen, Jiaur R, Wollam, Joshua, Vu, Christine U, Chi, Nai-Wen, O'Connor, Daniel T, Mahata, Sushil K

“…Chromogranin A knockout (Chga-KO) mice exhibit enhanced insulin sensitivity despite obesity. Here, we probed the role of the chromogranin A-derived peptide…”
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Proteomics of Dense Core Secretory Vesicles Reveal Distinct Protein Categories for Secretion of Neuroeffectors for Cell−Cell Communication by Wegrzyn, Jill L, Bark, Steven J, Funkelstein, Lydiane, Mosier, Charles, Yap, Angel, Kazemi-Esfarjani, Parsa, La Spada, Albert R, Sigurdson, Christina, O’Connor, Daniel T, Hook, Vivian

“…Regulated secretion of neurotransmitters and neurohumoral factors from dense core secretory vesicles provides essential neuroeffectors for cell−cell…”
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Cone-Beam Breast Computed Tomography: Time for a New Paradigm in Breast Imaging by O'Connell, Avice M., Marini, Thomas J., Kawakyu-O'Connor, Daniel T.

“…It is time to reconsider how we image the breast. Although the breast is a 3D structure, we have traditionally used 2D mammography to perform screening and…”
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A new common functional coding variant at the DDC gene change renal enzyme activity and modify renal dopamine function by Miramontes-Gonzalez, Jose Pablo, Hightower, C. Makena, Zhang, Kuixing, Kurosaki, Hiroki, Schork, Andrew J., Biswas, Nilima, Vaingankar, Sucheta, Mahata, Manjula, Lipkowitz, Michael S., Nievergelt, Caroline M., Baker, Dewleen G., Ziegler, Michael G., León-Jiménez, David, González-Sarmiento, Rogelio, Ichinose, Hiroshi, O’Connor, Daniel T.

“…The intra-renal dopamine (DA) system is highly expressed in the proximal tubule and contributes to Na+ and blood pressure homeostasis, as well as to the…”
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Novel Peptide Isomer Strategy for Stable Inhibition of Catecholamine Release: Application to Hypertension by Biswas, Nilima, Gayen, Jiaur, Mahata, Manjula, Su, Ying, Mahata, Sushil K, O’Connor, Daniel T

“…Although hypertension remains the most potent and widespread cardiovascular risk factor, its pharmacological treatment has achieved only limited success. The…”
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Hereditary Determinants of Human Hypertension: Strategies in the Setting of Genetic Complexity by Shih, Pei-an Betty, O’Connor, Daniel T

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Population-Based Sample Reveals Gene–Gender Interactions in Blood Pressure in White Americans by Rana, Brinda K, Insel, Paul A, Payne, Samuel H, Abel, Kenneth, Beutler, Ernest, Ziegler, Michael G, Schork, Nicholas J, O’Connor, Daniel T

“…The influence of genetic contributors, such as common single nucleotide polymorphisms, on blood pressure and essential hypertension may vary with the gender…”
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