Search Results - "OʼBrien, John T"

[11C]PK11195 binding in Alzheimer disease and progressive supranuclear palsy by Passamonti, Luca, Rodríguez, Patricia Vázquez, Hong, Young T, Allinson, Kieren S.J, Bevan-Jones, W Richard, Williamson, David, Jones, P Simon, Arnold, Robert, Borchert, Robin J, Surendranathan, Ajenthan, Mak, Elijah, Su, Li, Fryer, Tim D, Aigbirhio, Franklin I, OʼBrien, John T, Rowe, James B

“…OBJECTIVEWe tested whether in vivo neuroinflammation relates to the distinctive distributions of pathology in Alzheimer disease (AD) and progressive…”
Get full text

Cholinergic and perfusion brain networks in Parkinson disease dementia by Colloby, Sean J, McKeith, Ian G, Burn, David J, Wyper, David J, OʼBrien, John T, Taylor, John-Paul

“…OBJECTIVE:To investigate muscarinic M1/M4 cholinergic networks in Parkinson disease dementia (PDD) and their association with changes in Mini-Mental State…”
Get full text

Vascular dementia by O'Brien, John T, Prof, Thomas, Alan, Prof

“…Summary Vascular dementia is one of the most common causes of dementia after Alzheimer's disease, causing around 15% of cases. However, unlike Alzheimer's…”
Get full text

Autopsy validation of 123I-FP-CIT dopaminergic neuroimaging for the diagnosis of DLB by Thomas, Alan J, Attems, Johannes, Colloby, Sean J, OʼBrien, John T, McKeith, Ian, Walker, Rodney, Lee, Lean, Burn, David, Lett, Debra J, Walker, Zuzana

“…OBJECTIVE:To conduct a validation study of I-N-fluoropropyl-2b-carbomethoxy-3b-(4-iodophenyl) nortropane (I-FP-CIT) SPECT dopaminergic imaging in the clinical…”
Get full text

Depression and cognition in older adults by Thomas, Alan J, OʼBrien, John T

“…PURPOSE OF REVIEWRecognition that depression is associated with neurocognitive impairment and renewed recent interest in milder forms of cognitive impairment…”
Get full text

The use of neuroimaging techniques in the early and differential diagnosis of dementia by Chouliaras, Leonidas, O’Brien, John T.

“…Dementia is a leading cause of disability and death worldwide. At present there is no disease modifying treatment for any of the most common types of dementia…”
Get full text

Inflammation and cerebral small vessel disease: A systematic review by Low, Audrey, Mak, Elijah, Rowe, James B, Markus, Hugh S, O'Brien, John T

“…Inflammation is increasingly implicated as a risk factor for dementia, stroke, and small vessel disease (SVD). However, the underlying mechanisms and causative…”
Get full text

Identifying dementia outcomes in UK Biobank: a validation study of primary care, hospital admissions and mortality data by Wilkinson, Tim, Schnier, Christian, Bush, Kathryn, Rannikmäe, Kristiina, Henshall, David E., Lerpiniere, Chris, Allen, Naomi E., Flaig, Robin, Russ, Tom C., Bathgate, Deborah, Pal, Suvankar, O’Brien, John T., Sudlow, Cathie L. M.

“…Prospective, population-based studies that recruit participants in mid-life are valuable resources for dementia research. Follow-up in these studies is often…”
Get full text

A synergistic core for human brain evolution and cognition by Luppi, Andrea I., Mediano, Pedro A. M., Rosas, Fernando E., Holland, Negin, Fryer, Tim D., O’Brien, John T., Rowe, James B., Menon, David K., Bor, Daniel, Stamatakis, Emmanuel A.

“…How does the organization of neural information processing enable humans’ sophisticated cognition? Here we decompose functional interactions between brain…”
Get full text

Dementia with Lewy bodies — from scientific knowledge to clinical insights by Arnaoutoglou, Nikitas A., O’Brien, John T., Underwood, Benjamin R.

“…Dementia with Lewy bodies (DLB) is the underlying aetiology of 10–15% of all cases of dementia and as such is a clinically important diagnosis. In the past few…”
Get full text

A volumetric study of MRI signal hyperintensities in late-life depression by Firbank, Michael J, Lloyd, Adrian J, Ferrier, Nicol, O'Brien, John T

“…An increase in white-matter lesions has been previously described in older subjects with depression. The authors investigated whether the regional location…”
Get more information

New evidence on the management of Lewy body dementia by Taylor, John-Paul, McKeith, Ian G, Burn, David J, Boeve, Brad F, Weintraub, Daniel, Bamford, Claire, Allan, Louise M, Thomas, Alan J, O'Brien, John T

“…Dementia with Lewy bodies and Parkinson's disease dementia, jointly known as Lewy body dementia, are common neurodegenerative conditions. Patients with Lewy…”
Get full text

Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium by McKeith, Ian G, Boeve, Bradley F, Dickson, Dennis W, Halliday, Glenda, Taylor, John-Paul, Weintraub, Daniel, Aarsland, Dag, Galvin, James, Attems, Johannes, Ballard, Clive G, Bayston, Ashley, Beach, Thomas G, Blanc, Frédéric, Bohnen, Nicolaas, Bonanni, Laura, Bras, Jose, Brundin, Patrik, Burn, David, Chen-Plotkin, Alice, Duda, John E, El-Agnaf, Omar, Feldman, Howard, Ferman, Tanis J, ffytche, Dominic, Fujishiro, Hiroshige, Galasko, Douglas, Goldman, Jennifer G, Gomperts, Stephen N, Graff-Radford, Neill R, Honig, Lawrence S, Iranzo, Alex, Kantarci, Kejal, Kaufer, Daniel, Kukull, Walter, Lee, Virginia M.Y, Leverenz, James B, Lewis, Simon, Lippa, Carol, Lunde, Angela, Masellis, Mario, Masliah, Eliezer, McLean, Pamela, Mollenhauer, Brit, Montine, Thomas J, Moreno, Emilio, Mori, Etsuro, Murray, Melissa, OʼBrien, John T, Orimo, Sotoshi, Postuma, Ronald B, Ramaswamy, Shankar, Ross, Owen A, Salmon, David P, Singleton, Andrew, Taylor, Angela, Thomas, Alan, Tiraboschi, Pietro, Toledo, Jon B, Trojanowski, John Q, Tsuang, Debby, Walker, Zuzana, Yamada, Masahito, Kosaka, Kenji

“…The Dementia with Lewy Bodies (DLB) Consortium has refined its recommendations about the clinical and pathologic diagnosis of DLB, updating the previous…”
Get full text

Research criteria for the diagnosis of prodromal dementia with Lewy bodies by McKeith, Ian G., Ferman, Tanis J., Thomas, Alan J., Blanc, Frédéric, Boeve, Bradley F., Fujishiro, Hiroshige, Kantarci, Kejal, Muscio, Cristina, O'Brien, John T., Postuma, Ronald B., Aarsland, Dag, Ballard, Clive, Bonanni, Laura, Donaghy, Paul, Emre, Murat, Galvin, James E., Galasko, Douglas, Goldman, Jennifer G., Gomperts, Stephen N., Honig, Lawrence S., Ikeda, Manabu, Leverenz, James B., Lewis, Simon J.G., Marder, Karen S., Masellis, Mario, Salmon, David P., Taylor, John Paul, Tsuang, Debby W., Walker, Zuzana, Tiraboschi, Pietro

“…The prodromal phase of dementia with Lewy bodies (DLB) includes (1) mild cognitive impairment (MCI), (2) delirium-onset, and (3) psychiatric-onset…”
Get full text

Pharmacological Management of Lewy Body Dementia: A Systematic Review and Meta-Analysis by Stinton, Chris, McKeith, Ian, Taylor, John-Paul, Lafortune, Louise, Mioshi, Eneida, Mak, Elijah, Cambridge, Victoria, Mason, James, Thomas, Alan, O’Brien, John T.

“…Objective:The authors examined research on effects, costs, and patient and caregiver views of pharmacological management strategies for Lewy body…”
Get full text

MRI visual rating scales in the diagnosis of dementia: evaluation in 184 post-mortem confirmed cases by Harper, Lorna, Fumagalli, Giorgio G, Barkhof, Frederik, Scheltens, Philip, O'Brien, John T, Bouwman, Femke, Burton, Emma J, Rohrer, Jonathan D, Fox, Nick C, Ridgway, Gerard R, Schott, Jonathan M

“…Accurately distinguishing between different degenerative dementias during life is challenging but increasingly important with the prospect of disease-modifying…”
Get full text

Dysfunctional brain dynamics and their origin in Lewy body dementia by Schumacher, Julia, Peraza, Luis R, Firbank, Michael, Thomas, Alan J, Kaiser, Marcus, Gallagher, Peter, O'Brien, John T, Blamire, Andrew M, Taylor, John-Paul

“…Lewy body dementia includes dementia with Lewy bodies and Parkinson's disease dementia and is characterized by transient clinical symptoms such as fluctuating…”
Get full text

Characterizing mild cognitive impairment in incident Parkinson disease: The ICICLE-PD Study by Yarnall, Alison J, Breen, David P, Duncan, Gordon W, Khoo, Tien K, Coleman, Shirley Y, Firbank, Michael J, Nombela, Cristina, Winder-Rhodes, Sophie, Evans, Jonathan R, Rowe, James B, Mollenhauer, Brit, Kruse, Niels, Hudson, Gavin, Chinnery, Patrick F, O’Brien, John T, Robbins, Trevor W, Wesnes, Keith, Brooks, David J, Barker, Roger A, Burn, David J

“…OBJECTIVE:To describe the frequency of mild cognitive impairment (MCI) in Parkinson disease (PD) in a cohort of newly diagnosed incident PD cases and the…”
Get full text

Neuropsychiatric outcomes of stroke by Hackett, Maree L, PhD, Köhler, Sebastian, PhD, O'Brien, John T, Prof, Mead, Gillian E, Prof

“…Summary The most common neuropsychiatric outcomes of stroke are depression, anxiety, fatigue, and apathy, which each occur in at least 30% of patients and have…”
Get full text

Amyloid imaging for dementia in clinical practice by O'Brien, John T, Herholz, Karl

“…In vivo imaging of brain amyloid using positron emission tomography (PET) scanning is widely used in research studies of dementia, with three amyloid PET…”
Get full text