Search Results - "OʼBrien, John S"

Prosaposin Gene Expression and the Efficacy of a Prosaposin-derived Peptide in Preventing Structural and Functional Disorders of Peripheral Nerve in Diabetic Rats by Calcutt, Nigel A, Campana, W Marie, Eskeland, Nahida L, Mohiuddin, Liza, Dines, Kevin C, Mizisin, Andrew P, OʼBrien, John S

“…We have recently demonstrated that prosaposin is a neurotrophic and myelinotrophic factor with the active trophic sequence located at the N-terminal region of…”
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Prosaptide prevents hyperalgesia and reduces peripheral TNFR1 expression following TNF-α nerve injection by Wagner, Rochelle, Myers, Robert R, OʼBrien, John S

“…THIS study demonstrated that hyperalgesia resulting from an intraneural injection of the cytokine tumor necrosis factor-alpha (TNF) was prevented by preemptive…”
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Neuroprotective effect of retro-inverso Prosaptide D5 on focal cerebral ischemia in rat by Lu, Ai Gang, Otero, Deborah A. C, Hiraiwa, Masao, OʼBrien, John S

“…Prosaposin (the precursor of saposins A-D) has been identified as a neurotrophic factor in vitro and in vivo. In this study, a novel 11-mer retro-inverso…”
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Regulation of gene expression in response to brain injury: enhanced expression and alternative splicing of rat prosaposin (SGP-1) mRNA in injured brain by Hiraiwa, Masao, Liu, Jian, Lu, Ai-Gang, Wang, Cui-Ying, Misasi, Roberta, Yamauchi, Toyoaki, Hozumi, Isao, Inuzuka, Takashi, O'Brien, John S

“…Prosaposin, the precursor of saposins or saps, is an injury-repair protein that acts on both neurons and glia. Previous studies identified the prosaposin gene…”
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Cell Death Prevention, Mitogen-Activated Protein Kinase Stimulation, and Increased Sulfatide Concentrations in Schwann Cells and Oligodendrocytes by Prosaposin and Prosaptides by Hiraiwa, Masao, Taylor, Eve M., Campana, W. Marie, Darin, Sam J., O'Brien, John S.

“…Prosaposin, the precursor of saposins A, B, C, and D, was recently identified as a neurotrophic factor. Herein prosaposin was found to increase sulfatide…”
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Protection of sensory function and antihyperalgesic properties of a prosaposin-derived peptide in diabetic rats by CALCUTT, Nigel A, FRESHWATER, Jason D, O'BRIEN, John S

“…Short-term diabetes causes sensory disorders in rats ranging from thermal hypoalgesia to exaggerated behavioral responses to other sensory stimuli. As impaired…”
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Prosaposin treatment induces PC12 entry in the S phase of the cell cycle and prevents apoptosis: activation of ERKs and sphingosine kinase by MISASI, ROBERTA, SORICE, MAURIZIO, MARZIO, LUISA DI, CAMPANA, W. MARIE, MOLINARI, SABRINA, CIFONE, MARIA GRAZIA, PAVAN, ANTONIO, PONTIERI, GIUSEPPE M., O’BRIEN, JOHN S.

“…ABSTRACT We report that prosaposin treatment induced extracellular signal‐regulated kinases (ERKs) and sphingosine kinase activity, increased DNA synthesis,…”
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TX14(A), a Prosaposin-Derived Peptide, Reverses Established Nerve Disorders in Streptozotocin-Diabetic Rats and Prevents Them in Galactose-Fed Rats by MIZISIN, ANDREW P, STEINHARDT, RACHEL C, OʼBRIEN, JOHN S, CALCUTT, NIGEL A

“…Recently, TX14(A), a prosaposin-derived neurotrophic peptide, was shown to prevent both large and small fiber deficits in streptozotocin diabetes. Here, the…”
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Saposins ( sap) A and C activate the degradation of galactosylceramide in living cells by Harzer, Klaus, Paton, Barbara C, Christomanou, Helen, Chatelut, Martine, Levade, Thierry, Hiraiwa, Masao, O'Brien, John S

“…In loading tests using galactosylceramide which had been labelled with tritium in the ceramide moiety, living skin fibroblast lines derived from the original…”
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Prosaposin, a neurotrophic factor: presence and properties in milk by Patton, S, Carson, G S, Hiraiwa, M, O'Brien, J S, Sano, A

“…The presence of prosaposin, the precursor of the sphingolipid activator proteins (saposins A, B, C, and D), was investigated in bovine milk. The milk proteins…”
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Coding of Two Sphingolipid Activator Proteins (SAP-1 and SAP-2) by Same Genetic Locus by O'Brien, John S., Kretz, Keith A., Dewji, Nazneen, Wenger, David A., Esch, Fred, Fluharty, Arvan L.

“…Several complementary DNAs (cDNAs) coding for sphingolipid activator protein-2 (SAP-2) were isolated from a $\lambda $gt-11 human hepatoma library by means of…”
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Prosaposin is immunolocalized to muscle and prosaptides promote myoblast fusion and attenuate loss of muscle mass after nerve injury by Rende, Mario, Brizi, Emanuela, Donato, Rosario, Provenzano, Carlo, Bruno, Rosalinda, Mizisin, Andrew P., Garrett, Robert S., Calcutt, Nigel A., Campana, W. Marie, O'Brien, John S.

“…Prosaposin is the precursor of the saposins and has both neurotrophic and myelinotrophic activity in vitro and in vivo. Using an antibody specific for the…”
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Prosaptide activates the MAPK pathway by a G-protein-dependent mechanism essential for enhanced sulfatide synthesis by Schwann cells by Campana, W. Marie, Hiraiwa, Masao, O'Brien, John S.

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Saposin proteins: structure, function, and role in human lysosomal storage disorders by O'Brien, J S, Kishimoto, Y

“…Saposins are sphingolipid activator proteins, four of which are derived from a single precursor, prosaposin, by proteolytic processing. These small heat-stable…”
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Occurrence of prosaposin as a neuronal surface membrane component by Fu, Q, Carson, G S, Hiraiwa, M, Grafe, M, Kishimoto, Y, O'Brien, J S

“…Prosaposin is a precursor of four saposins that are required for the lysosomal hydrolysis of sphingolipids by specific hydrolases. Besides its precursor role,…”
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Lysosomal Proteolysis of Prosaposin, the Precursor of Saposins (Sphingolipid Activator Proteins): Its Mechanism and Inhibition by Ganglioside by Hiraiwa, Masao, Martin, Brian M., Kishimoto, Yasuo, Conner, Gregory E., Tsuji, Shoji, O'Brien, John S.

“…Saposins A, B, C, and D, which are required for the enzymatic hydrolysis of sphingolipids by specific lysosomal hydrolases, are produced by proteolytic…”
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Retro-inverso prosaptide peptides retain bioactivity, are stable In vivo, and are blood-brain barrier permeable by Taylor, E M, Otero, D A, Banks, W A, O'Brien, J S

“…Prosaptide (trademark of Myelos Corporation, San Diego, CA) peptides are based on the 14-amino-acid neurotrophic sequence of human prosaposin and, like the…”
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Synthesis of 2'-(4-methylumbelliferyl)-.alpha.-D-N-acetylneuraminic acid and detection of skin fibroblast neuraminidase in normal humans and in sialidosis by Warner, Thomas G, O'Brien, John S

“…A procedure for the synthesis of the fluorogenic substrate analogue 2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid for the human acid neuraminidase…”
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A fragment of prosaposin (SGP-1) from rooster sperm promotes sperm-egg binding and improves fertility in chickens by Hammerstedt, R. H, Cramer, P. G, Barbato, G. F, Amann, R. P, O'Brien, J. S, Griswold, M. D

“…A protein isolated from the supernatant of cryopreserved rooster sperm was found to increase the capability of cryopreserved rooster sperm to bind in vitro to…”
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Spectrum of mutations in fucosidosis by Willems, P J, Seo, H C, Coucke, P, Tonlorenzi, R, O'Brien, J S

“…Fucosidosis is a lysosomal storage disorder characterised by progressive psychomotor deterioration, angiokeratoma and growth retardation. It is due to…”
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