The effects of chronic administration of sumatriptan and dipyrone on serotonergic system in the rat brain: an immunohistochemical study

Objective – To investigate the effects of chronic high dose sumatriptan and dipyrone treatment on central serotonergic system in rats. Materials and methods – Male Sprague–Dawley rats (seven per group) were daily injected with sumatriptan (3 mg/kg), dipyrone (400 mg/kg) or saline for 30 days. The...

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Published in:	Acta neurologica Scandinavica Vol. 120; no. 4; pp. 264 - 269
Main Authors:	Genç, E., Avunduk, M. C., Oğuz Genç, B., Saide Şahin, A., Öz, M.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-10-2009 Blackwell
Subjects:	Analysis of Variance Animals Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - pharmacology Biological and medical sciences Brain - cytology Brain - drug effects Brain - metabolism dipyrone Dipyrone - administration & dosage Dipyrone - pharmacology Diseases of the osteoarticular system immunohistochemical staining Male Medical sciences Neurology Neurons - drug effects Neurons - metabolism rat Rats Rats, Sprague-Dawley serotonin expression Serotonin Receptor Agonists - administration & dosage Serotonin Receptor Agonists - pharmacology sumatriptan Sumatriptan - administration & dosage Sumatriptan - pharmacology Tumors of striated muscle and skeleton Immunohistochemistry Nervous system diseases dipyrone Rat Serotonin Rodentia Central nervous system Encephalon Vertebrata Chronic Mammalia Animal Neurotransmitter immunohistochemical staining: rat serotonin expression sumatriptan
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Summary:	Objective – To investigate the effects of chronic high dose sumatriptan and dipyrone treatment on central serotonergic system in rats. Materials and methods – Male Sprague–Dawley rats (seven per group) were daily injected with sumatriptan (3 mg/kg), dipyrone (400 mg/kg) or saline for 30 days. The brains of animals were surgically removed and immunohistochemically stained for serotonin. Serotonin‐positive stained cells were counted automatically by using a computerized image analysis program. Statistical analysis carried out using one‐way ANOVA followed by post hoc Tukey test. Results – A significant decrease in serotonin‐positive cells in the brainstem was observed after chronic sumatriptan administration while chronic use of dipyrone induced a significant increase in serotonin‐positive cells both in the cortex and midbrain. Conclusion – Our data suggest that central serotonergic system might be modified by chronic use of sumatriptan and dipyrone.
Bibliography:	istex:BB714D3EE7ABFBE7C41B2E7339260E7D8B2FB095 ark:/67375/WNG-G2TQZ1WW-9 ArticleID:ANE1153 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0001-6314 1600-0404
DOI:	10.1111/j.1600-0404.2008.01153.x