Search Results - "O'sullivan, Jeremy A."

Eosinophils and eosinophil-associated diseases: An update by O'Sullivan, Jeremy A., Bochner, Bruce S.

“…The goal of this series is to offer a survey of the latest literature for clinicians and scientists alike, providing a list of important recent advances…”
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Eosinophil and mast cell Siglecs: From biology to drug target by O'Sullivan, Jeremy A., Chang, Alan T., Youngblood, Bradford A., Bochner, Bruce S.

“…Mast cells and eosinophils are innate immune cells involved in both acute and chronic inflammatory responses. Siglecs are a family of cell surface receptors…”
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Memory Precursors and Short-Lived Effector T cell Subsets Have Different Sensitivities to TGFβ by O'Sullivan, Jeremy A, Kohlhapp, Frederick J, Zloza, Andrew, Plaza-Rojas, Lourdes, Burke, Brianna, Dulin, Nickolai O, Guevara-Patiño, José A

“…After exposure to an antigen, CD8 T cells reach a decision point about their fate: to become either short-lived effector cells (SLECs) or memory progenitor…”
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Siglecs in allergy and asthma by Bochner, Bruce S., O'Sullivan, Jeremy A., Chang, Alan T., Youngblood, Bradford A.

“…The term “allergic diseases” encompasses several common, IgE-mediated conditions that range from being annoying to those that are life-threatening. Available…”
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Leveraging Siglec-8 endocytic mechanisms to kill human eosinophils and malignant mast cells by O'Sullivan, Jeremy A., Carroll, Daniela J., Cao, Yun, Salicru, Adriano N., Bochner, Bruce S.

“…Sialic acid–binding immunoglobulin-like lectin (Siglec)-8 is a cell-surface protein expressed selectively on human eosinophils, mast cells, and basophils,…”
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Siglecs as potential targets of therapy in human mast cell- and/or eosinophil-associated diseases by O’Sullivan, Jeremy A., Youngblood, Bradford A., Schleimer, Robert P., Bochner, Bruce S.

“…Siglecs (sialic acid-binding immunoglobulin-like lectins) are a family of vertebrate glycan-binding cell-surface proteins. The majority mediate cellular…”
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Siglec-8 Signals Through a Non-Canonical Pathway to Cause Human Eosinophil Death In Vitro by Carroll, Daniela J, Cao, Yun, Bochner, Bruce S, O'Sullivan, Jeremy A

“…Sialic acid-binding immunoglobulin-like lectin (Siglec)-8 is a glycan-binding receptor bearing immunoreceptor tyrosine-based inhibitory and switch motifs (ITIM…”
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Interactions between Siglec-8 and endogenous sialylated cis ligands restrain cell death induction in human eosinophils and mast cells by Cao, Yun, Rische, Clayton H, Bochner, Bruce S, O'Sullivan, Jeremy A

“…Sialic acid-binding immunoglobulin-like lectin (Siglec)-8 is a sialoside-binding receptor expressed by eosinophils and mast cells that exhibits priming status-…”
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NKG2D signaling shifts the balance of CD8 T cells from single cytokine- to polycytokine-producing effector cells by Kohlhapp, Frederick J., O’Sullivan, Jeremy A., Moore, Tamson V., Zloza, Andrew, Guevara-Patiño, José A.

“…CD8 T cells play a critical role in immunity against intracellular pathogens and cancer. A primary objective of T cell-based vaccine strategies is the…”
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Drug delivery targets and strategies to address mast cell diseases by Rische, Clayton H, Thames, Ariel N, Krier-Burris, Rebecca A, O'Sullivan, Jeremy A, Bochner, Bruce S, Scott, Evan A

“…Current and developing mast cell therapeutics are reliant on small molecule drugs and biologics, but few are truly selective for mast cells. Most have cellular…”
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Frontline Science: Characterization of a novel mouse strain expressing human Siglec‐8 only on eosinophils by O'Sullivan, Jeremy A., Wei, Yadong, Carroll, Daniela J., Moreno‐Vinasco, Liliana, Cao, Yun, Zhang, Fengrui, Lee, James. J., Zhu, Zhou, Bochner, Bruce S.

“…Sialic acid‐binding immunoglobulin‐like lectin (Siglec)‐8 is a human cell surface protein expressed exclusively on eosinophils, mast cells, and basophils that,…”
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Single-site, five-year experience with human eosinophil isolation by density gradient centrifugation and CD16 immunomagnetic negative separation by Cao, Yun, Shin, Sooncheon, Carroll, Daniela J, O'Sullivan, Jeremy A, Bochner, Bruce S

“…Little has been reported regarding the reliability of methods for the purification of human blood eosinophils. We retrospectively reviewed our experience with…”
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Identification of a Siglec‐F+ granulocyte‐macrophage progenitor by Bolden, Jessica E., Lucas, Erin C., Zhou, Geyu, O'Sullivan, Jeremy A., Graaf, Carolyn A., McKenzie, Mark D., Di Rago, Ladina, Baldwin, Tracey M., Shortt, Jake, Alexander, Warren S., Bochner, Bruce S., Ritchie, Matthew E., Hilton, Douglas J., Fairfax, Kirsten A.

“…In recent years multi‐parameter flow cytometry has enabled identification of cells at major stages in myeloid development; from pluripotent hematopoietic stem…”
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Glycobiology of Eosinophilic Inflammation: Contributions of Siglecs, Glycans, and Other Glycan-Binding Proteins by O'Sullivan, Jeremy A, Carroll, Daniela J, Bochner, Bruce S

“…The historical focus on protein-protein interactions in biological systems, at the expense of attention given to interactions between other classes of…”
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NKG2D signaling on CD8+ T cells represses T-bet and rescues CD4-unhelped CD8+ T cell memory recall but not effector responses by Zloza, Andrew, Kohlhapp, Frederick J, Lyons, Gretchen E, Schenkel, Jason M, Moore, Tamson V, Lacek, Andrew T, O'Sullivan, Jeremy A, Varanasi, Vineeth, Williams, Jesse W, Jagoda, Michael C, Bellavance, Emily C, Marzo, Amanda L, Thomas, Paul G, Zafirova, Biljana, Polić, Bojan, Al-Harthi, Lena, Sperling, Anne I, Guevara-Patiño, José A

“…CD8 + T cells primed in the absence of CD4 + T cell help fail to develop a robust memory cell response. Zloza et al . now report that these CD4-unhelped CD8 +…”
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Stimulation of the glucocorticoid-induced TNF receptor family-related receptor on CD8 T cells induces protective and high-avidity T cell responses to tumor-specific antigens by Côté, Anik L, Zhang, Peisheng, O'Sullivan, Jeremy A, Jacobs, Valerie L, Clemis, Carli R, Sakaguchi, Shimon, Guevara-Patiño, José A, Turk, Mary Jo

“…Treatment of tumor-bearing mice with a stimulatory Ab to glucocorticoid-induced TNFR family-related receptor (GITR) has previously been shown to elicit…”
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Development of tumor-infiltrating CD8+ T cell memory precursor effector cells and antimelanoma memory responses are the result of vaccination and TGF-β blockade during the perioperative period of tumor resection by Bellavance, Emily C, Kohlhapp, Frederick J, Zloza, Andrew, O'Sullivan, Jeremy A, McCracken, James, Jagoda, Michael C, Lacek, Andrew T, Posner, Mitchell C, Guevara-Patino, Jose A

“…A main goal of cancer immunology research is the formation of Ag-specific memory T cell immunity capable of activation upon tumor re-encounter. The…”
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CD8(+) T cells sabotage their own memory potential through IFN-γ-dependent modification of the IL-12/IL-15 receptor α axis on dendritic cells by Kohlhapp, Frederick J, Zloza, Andrew, O'Sullivan, Jeremy A, Moore, Tamson V, Lacek, Andrew T, Jagoda, Michael C, McCracken, James, Cole, David J, Guevara-Patiño, José A

“…CD8(+) T cell responses have been shown to be regulated by dendritic cells (DCs) and CD4(+) T cells, leading to the tenet that CD8(+) T cells play a passive…”
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Sialic acid–binding immunoglobulin-like lectin 8 (Siglec-8) is an activating receptor mediating β2-integrin–dependent function in human eosinophils by Carroll, Daniela J., O'Sullivan, Jeremy A., Nix, David B., Cao, Yun, Tiemeyer, Michael, Bochner, Bruce S.

“…Siglec-8 is a CD33 subfamily cell-surface receptor selectively expressed on human eosinophils. After cytokine priming, Siglec-8 mAb or glycan ligand binding…”
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CD8 Co-receptor promotes susceptibility of CD8⁺ T cells to transforming growth factor-β (TGF-β)-mediated suppression by Zloza, Andrew, Jagoda, Michael C, Lyons, Gretchen E, Graves, Michael C, Kohlhapp, Frederick J, O'Sullivan, Jeremy A, Lacek, Andrew T, Nishimura, Michael I, Guevara-Patiño, José A

“…CD8⁺ T cell function depends on a finely orchestrated balance of activation/suppression signals. While the stimulatory role of the CD8 co-receptor and…”
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