Search Results - "O'rahilly, S"

GWAS for BMI: a treasure trove of fundamental insights into the genetic basis of obesity by Speakman, J. R., Loos, R. J. F., O’Rahilly, S., Hirschhorn, J. N., Allison, D. B.

“…Summary Muller et al. [ 1 ] have provided a strong critique of the Genome-Wide Association Studies (GWAS) of body-mass index (BMI), arguing that the GWAS…”
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GDF15 linked to maternal risk of nausea and vomiting during pregnancy by Fejzo, M., Rocha, N., Cimino, I., Lockhart, S. M., Petry, C. J., Kay, R. G., Burling, K., Barker, P., George, A. L., Yasara, N., Premawardhena, A., Gong, S., Cook, E., Rimmington, D., Rainbow, K., Withers, D. J., Cortessis, V., Mullin, P. M., MacGibbon, K. W., Jin, E., Kam, A., Campbell, A., Polasek, O., Tzoneva, G., Gribble, F. M., Yeo, G. S. H., Lam, B. Y. H., Saudek, V., Hughes, I. A., Ong, K. K., Perry, J. R. B., Sutton Cole, A., Baumgarten, M., Welsh, P., Sattar, N., Smith, G. C. S., Charnock-Jones, D. S., Coll, A. P., Meek, C. L., Mettananda, S., Hayward, C., Mancuso, N., O’Rahilly, S.

“…GDF15, a hormone acting on the brainstem, has been implicated in the nausea and vomiting of pregnancy, including its most severe form, hyperemesis gravidarum…”
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Circulating levels of GDF15 in patients with myalgic encephalomyelitis/chronic fatigue syndrome by Melvin, A, Lacerda, E, Dockrell, H M, O'Rahilly, S, Nacul, L

“…Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating condition characterised by fatigue and post-exertional malaise. Its pathogenesis…”
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Ethnic differences in complement system biomarkers and their association with metabolic health in men of Black African and White European ethnicity by Goff, L M, Davies, K, Zelek, W M, Kodosaki, E, Hakim, O, Lockhart, S, O’Rahilly, S, Morgan, B P

“…Abstract Inflammation plays a fundamental role in the development of several metabolic diseases, including obesity and type 2 diabetes (T2D); the complement…”
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MC3R links nutritional state to childhood growth and the timing of puberty by Lam, B. Y. H., Williamson, A., Finer, S., Day, F. R., Tadross, J. A., Gonçalves Soares, A., Wade, K., Sweeney, P., Bedenbaugh, M. N., Porter, D. T., Melvin, A., Ellacott, K. L. J., Lippert, R. N., Buller, S., Rosmaninho-Salgado, J., Dowsett, G. K. C., Ridley, K. E., Xu, Z., Cimino, I., Rimmington, D., Rainbow, K., Duckett, K., Holmqvist, S., Khan, A., Dai, X., Bochukova, E. G., Trembath, R. C., Martin, H. C., Coll, A. P., Rowitch, D. H., Wareham, N. J., van Heel, D. A., Timpson, N., Simerly, R. B., Ong, K. K., Cone, R. D., Langenberg, C., Perry, J. R. B., Yeo, G. S., O’Rahilly, S.

“…The state of somatic energy stores in metazoans is communicated to the brain, which regulates key aspects of behaviour, growth, nutrient partitioning and…”
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Correlation of the leptin:adiponectin ratio with measures of insulin resistance in non-diabetic individuals by Finucane, F. M, Luan, J, Wareham, N. J, Sharp, S. J, O'Rahilly, S, Balkau, B, Flyvbjerg, A, Walker, M, Højlund, K, Nolan, J. J, Savage, D. B

“…Aims/hypothesis Obesity is the dominant cause of insulin resistance. In adult humans it is characterised by a combination of adipocyte hypertrophy and, to a…”
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Human obesity as a heritable disorder of the central control of energy balance by O'Rahilly, S, Farooqi, I.S

“…In the spirit of celebration associated with the 20th anniversary of the Pennington Biomedical Research Center, we have seized the opportunity of taking a…”
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An Activating Mutation of AKT2 and Human Hypoglycemia by Hussain, K., Challis, B., Rocha, N., Payne, F., Minic, M., Thompson, A., Daly, A., Scott, C., Harris, J., Smillie, B. J. L., Savage, D. B., Ramaswami, U., De Lonlay, P., O'Rahilly, S., Barroso, I., Semple, R. K.

“…Pathological fasting hypoglycemia in humans is usually explained by excessive circulating insulin or insulin-like molecules or by inborn errors of metabolism…”
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Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent by Romeo, S, Sentinelli, F, Dash, S, Yeo, G S H, Savage, D B, Leonetti, F, Capoccia, D, Incani, M, Maglio, C, Iacovino, M, O'Rahilly, S, Baroni, M G

“…Context: The PNPLA3 I148M variant (rs738409) is robustly associated with hepatic steatosis. Intriguingly, initial findings in cohorts with a mean body mass…”
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Associations between body composition, glycaemia and complement C3 in black African and white European men by Reed, R.M., Hakim, O., Lockhart, S., O'Rahilly, S., Whyte, M.B., Goff, L.M.

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Loss of Mrap2 is associated with Sim1 deficiency and increased circulating cholesterol by Novoselova, T V, Larder, R, Rimmington, D, Lelliott, C, Wynn, E H, Gorrigan, R J, Tate, P H, Guasti, L, O’Rahilly, S, Clark, A J L, Logan, D W, Coll, A P, Chan, L F

“…Melanocortin receptor accessory protein 2 (MRAP2) is a transmembrane accessory protein predominantly expressed in the brain. Both global and brain-specific…”
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FTO expression is regulated by availability of essential amino acids by Cheung, M K, Gulati, P, O'Rahilly, S, Yeo, G S H

“…Genome-wide association studies have revealed that single nucleotide polymorphisms in fat mass and obesity-associated transcript (FTO) are robustly associated…”
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Acute effects of PYY3-36 on food intake and hypothalamic neuropeptide expression in the mouse by Challis, B G, Pinnock, S B, Coll, A P, Carter, R N, Dickson, S L, O'Rahilly, S

“…It has recently been suggested that gut-derived PYY(3-36) may be involved in the central mediation of post-prandial satiety signals. We have examined the acute…”
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Elevated Plasma Adiponectin in Humans with Genetically Defective Insulin Receptors by Semple, R. K., Soos, M. A., Luan, J., Mitchell, C. S., Wilson, J. C., Gurnell, M., Cochran, E. K., Gorden, P., Chatterjee, V. K. K., Wareham, N. J., O’Rahilly, S.

“…Context: Adiponectin has been suggested to play a role in the etiopathogenesis of at least some forms of insulin resistance, in part based on a strong…”
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Two Novel Missense Mutations in G Protein-Coupled Receptor 54 in a Patient with Hypogonadotropic Hypogonadism by Semple, R. K., Achermann, J. C., Ellery, J., Farooqi, I. S., Karet, F. E., Stanhope, R. G., O’Rahilly, S., Aparicio, S. A.

“…It has recently been shown that loss-of-function mutations of the G protein-coupled receptor (GPR)54 lead to isolated hypogonadotropic hypogonadism (IHH) in…”
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Mechanistic insights into insulin resistance in the genetic era by Parker, V. E. R., Savage, D. B., O'Rahilly, S., Semple, R. K.

“…Diabet. Med. 28, 1476–1486 (2011) Sir Harold Himsworth first observed and articulated the phenomenon of insulin resistance in the late 1930s. Although a long…”
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The perils of portliness: causes and consequences of visceral adiposity by MONTAGUE, C. T, O'RAHILLY, S

“…The perils of portliness: causes and consequences of visceral adiposity. C T Montague and S O'Rahilly Cardiovascular and Gastrointestinal Discovery Research…”
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Effects of the mu-opioid receptor antagonist GSK1521498 on hedonic and consummatory eating behaviour: a proof of mechanism study in binge-eating obese subjects by Ziauddeen, H, Chamberlain, S R, Nathan, P J, Koch, A, Maltby, K, Bush, M, Tao, W X, Napolitano, A, Skeggs, A L, Brooke, A C, Cheke, L, Clayton, N S, Sadaf Farooqi, I, O'Rahilly, S, Waterworth, D, Song, K, Hosking, L, Richards, D B, Fletcher, P C, Bullmore, E T

“…The opioid system is implicated in the hedonic and motivational processing of food, and in binge eating, a behaviour strongly linked to obesity. The aim of…”
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Serotonin Activates the Hypothalamic-Pituitary-Adrenal Axis via Serotonin 2C Receptor Stimulation by Heisler, Lora K, Pronchuk, Nina, Nonogaki, Katsunori, Zhou, Ligang, Raber, Jacob, Tung, Loraine, Yeo, Giles S. H, O'Rahilly, Stephen, Colmers, William F, Elmquist, Joel K, Tecott, Laurence H

“…The dynamic interplay between serotonin [5-hydroxytryptamine (5-HT)] neurotransmission and the hypothalamic-pituitary-adrenal (HPA) axis has been extensively…”
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The transcription factors Egr1 and Egr2 have opposing influences on adipocyte differentiation by Boyle, K B, Hadaschik, D, Virtue, S, Cawthorn, W P, Ridley, S H, O'Rahilly, S, Siddle, K

“…The zinc finger-containing transcription factors Egr1 (Krox24) and Egr2 (Krox20) have been implicated in the proliferation and differentiation of many cell…”
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