Search Results - "O'cualain, Ronan"

Identification of a major epitope recognized by PLA2R autoantibodies in primary membranous nephropathy by Fresquet, Maryline, Jowitt, Thomas A, Gummadova, Jennet, Collins, Richard, O'Cualain, Ronan, McKenzie, Edward A, Lennon, Rachel, Brenchley, Paul E

“…Phospholipase A2 receptor 1 (PLA2R) is a target autoantigen in 70% of patients with idiopathic membranous nephropathy. We describe the location of a major…”
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Fatty Acid Supplementation Reverses the Small Colony Variant Phenotype in Triclosan-Adapted Staphylococcus aureus: Genetic, Proteomic and Phenotypic Analyses by Bazaid, Abdulrahman S., Forbes, Sarah, Humphreys, Gavin J., Ledder, Ruth G., O’Cualain, Ronan, McBain, Andrew J.

“…Staphylococcus aureus can develop a small colony variant (SCV) phenotype in response to sub-lethal exposure to the biocide triclosan. In the current study,…”
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Proteogenomic Gene Structure Validation in the Pineapple Genome by Ariffin, Norazrin, Newman, David Wells, Nelson, Michael G., O’cualain, Ronan, Hubbard, Simon J.

“…MD2 pineapple (Ananas comosus) is the second most important tropical crop that preserves crassulacean acid metabolism (CAM), which has high water-use…”
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Structural and compositional diversity of fibrillin microfibrils in human tissues by Eckersley, Alexander, Mellody, Kieran T., Pilkington, Suzanne, Griffiths, Christopher E.M., Watson, Rachel E.B., O’Cualain, Ronan, Baldock, Clair, Knight, David, Sherratt, Michael J.

“…Elastic fibers comprising fibrillin microfibrils and elastin are present in many tissues, including the skin, lungs, and arteries, where they confer elasticity…”
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Dynamic Acclimation to High Light in Arabidopsis thaliana Involves Widespread Reengineering of the Leaf Proteome by Miller, Matthew A E, O'Cualain, Ronan, Selley, Julian, Knight, David, Karim, Mohd F, Hubbard, Simon J, Johnson, Giles N

“…Leaves of transferred from low to high light increase their capacity for photosynthesis, a process of dynamic acclimation. A mutant, , lacking a chloroplast…”
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Laser capture microdissection coupled mass spectrometry (LCM-MS) for spatially resolved analysis of formalin-fixed and stained human lung tissues by Herrera, Jeremy A, Mallikarjun, Venkatesh, Rosini, Silvia, Montero, Maria Angeles, Lawless, Craig, Warwood, Stacey, O'Cualain, Ronan, Knight, David, Schwartz, Martin A, Swift, Joe

“…Haematoxylin and eosin (H&E)-which respectively stain nuclei blue and other cellular and stromal material pink-are routinely used for clinical diagnosis based…”
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Global absolute quantification of a proteome: Challenges in the deployment of a QconCAT strategy by Brownridge, Philip, Holman, Stephen W., Gaskell, Simon J., Grant, Christopher M., Harman, Victoria M., Hubbard, Simon J., Lanthaler, Karin, Lawless, Craig, O'cualain, Ronan, Sims, Paul, Watkins, Rachel, Beynon, Robert J.

“…In this paper, we discuss the challenge of large‐scale quantification of a proteome, referring to our programme that aims to define the absolute quantity, in…”
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A protein-centric approach for the identification of folate enzymes from the malarial parasite, Plasmodium falciparum, using OFFGEL™ solution-based isoelectric focussing and mass spectrometry by O'Cualain, Ronan D M, Hyde, John E, Sims, Paul F G

“…Plasmodium species are difficult to study using proteomic technology because they contain large amounts of haemoglobin-derived products (HDP), generated by…”
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Proteomic fingerprints of damage in extracellular matrix assemblies by Eckersley, Alexander, Ozols, Matiss, O'Cualain, Ronan, Keevill, Emma-Jayne, Foster, April, Pilkington, Suzanne, Knight, David, Griffiths, Christopher E.M., Watson, Rachel E.B., Sherratt, Michael J.

“…In contrast to the dynamic intracellular environment, structural extracellular matrix (ECM) proteins with half-lives measured in decades, are susceptible to…”
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Ultrafast red light activation of Synechocystis phytochrome Cph1 triggers major structural change to form the Pfr signalling-competent state by Heyes, Derren J, Khara, Basile, Sakuma, Michiyo, Hardman, Samantha J O, O'Cualain, Ronan, Rigby, Stephen E J, Scrutton, Nigel S

“…Phytochromes are dimeric photoreceptors that regulate a range of responses in plants and microorganisms through interconversion of red light-absorbing (Pr) and…”
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Increased peri-ductal collagen micro-organization may contribute to raised mammographic density by McConnell, James C, O'Connell, Oliver V, Brennan, Keith, Weiping, Lisa, Howe, Miles, Joseph, Leena, Knight, David, O'Cualain, Ronan, Lim, Yit, Leek, Angela, Waddington, Rachael, Rogan, Jane, Astley, Susan M, Gandhi, Ashu, Kirwan, Cliona C, Sherratt, Michael J, Streuli, Charles H

“…High mammographic density is a therapeutically modifiable risk factor for breast cancer. Although mammographic density is correlated with the relative…”
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Quantitative analysis of competitive cytokine signaling predicts tissue thresholds for the propagation of macrophage activation by Bagnall, James, Boddington, Christopher, England, Hazel, Brignall, Ruth, Downton, Polly, Alsoufi, Zainab, Boyd, James, Rowe, William, Bennett, Alexander, Walker, Catherine, Adamson, Antony, Patel, Nisha M X, O'Cualain, Ronan, Schmidt, Lorraine, Spiller, David G, Jackson, Dean A, Müller, Werner, Muldoon, Mark, White, Michael R H, Paszek, Pawel

“…Toll-like receptor (TLR) signaling regulates macrophage activation and effector cytokine propagation in the constrained environment of a tissue. In macrophage…”
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Protocol to characterize basement membranes during kidney development using mass spectrometry-based label-free quantitative proteomics by Morais, Mychel R.P.T., Tian, Pinyuan, O’cualain, Ronan, Lawless, Craig, Lennon, Rachel

“…Basement membranes are specialized extracellular matrices formed by highly insoluble structural proteins and extracellular matrix (ECM)-bound components that…”
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Giant worm-shaped ESCRT scaffolds surround actin-independent integrin clusters by Stempels, Femmy C, Jiang, Muwei, Warner, Harry M, Moser, Magda-Lena, Janssens, Maaike H, Maassen, Sjors, Nelen, Iris H, de Boer, Rinse, Jiemy, William F, Knight, David, Selley, Julian, O'Cualain, Ronan, Baranov, Maksim V, Burgers, Thomas C Q, Sansevrino, Roberto, Milovanovic, Dragomir, Heeringa, Peter, Jones, Matthew C, Vlijm, Rifka, Ter Beest, Martin, van den Bogaart, Geert

“…Endosomal Sorting Complex Required for Transport (ESCRT) proteins can be transiently recruited to the plasma membrane for membrane repair and formation of…”
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Peptide location fingerprinting reveals modification‐associated biomarker candidates of ageing in human tissue proteomes by Ozols, Matiss, Eckersley, Alexander, Mellody, Kieran T., Mallikarjun, Venkatesh, Warwood, Stacey, O'Cualain, Ronan, Knight, David, Watson, Rachel E. B., Griffiths, Christopher E. M., Swift, Joe, Sherratt, Michael J.

“…Although dysfunctional protein homeostasis (proteostasis) is a key factor in many age‐related diseases, the untargeted identification of structurally modified…”
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Software for analysing ion mobility mass spectrometry data to improve peptide identification by Xia, Dong, Ghali, Fawaz, Gaskell, Simon J., O'Cualain, Ronan, Sims, Paul F. G., Jones, Andrew R.

“…The development of ion mobility (IM) MS instruments has the capability to provide an added dimension to peptide analysis pipelines in proteomics, but, as yet,…”
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Global absolute quantification of a proteome: Challenges in the deployment of a QconCAT strategy: Microbial Proteomics by BROWNRIDGE, Philip, HOLMAN, Stephen W, WATKINS, Rachel, BEYNON, Robert J, GASKELL, Simon J, GRANT, Christopher M, HARMAN, Victoria M, HUBBARD, Simon J, LANTHALER, Karin, LAWLESS, Craig, O'CUALAIN, Ronan, SIMS, Paul

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