Search Results - "O'connor, John C"

Comment on “High Production, Low Information: We Need To Know More About Polymeric Flame Retardants” by Hunter, Shawn E, O’Connor, John C

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Comment on “Degradation of the Polymeric Brominated Flame Retardant “Polymeric FR” by Heat and UV Exposure” by Buffey, Kelly, Davis, John W, Kram, Shari, Lukas, Christine, O’Connor, John C, Hunter, Shawn E

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Atmospheric moisture contribution to the growing season in the Amazon arc of deforestation by O’Connor, John C, Santos, Maria J, Dekker, Stefan C, Rebel, Karin T, Tuinenburg, Obbe A

“…Abstract The Amazon moisture recycling system has been widely examined because it is fundamental to maintain some of the global climate processes, however, we…”
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Evaluation of the reproductive and developmental toxicity of 6:2 fluorotelomer alcohol in rats by O’Connor, John C, Munley, Susan M, Serex, Tessa L, Buck, Robert C

“…Abstract 6:2 fluorotelomer alcohol (6:2 FTOH) was evaluated for potential developmental and reproductive toxicity. 6:2 FTOH was administered by oral gavage to…”
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Report from the BfR expert hearing on practicability of hormonal measurements: recommendations for experimental design of toxicological studies with integrated hormonal end points by Kucheryavenko, Olena, Lurman, Glenn, Lehmann, Anja, Braz, Juliana, Niemann, Lars, Chahoud, Ibrahim, Mantovani, Alberto, Håkansson, Helen, Schneider, Steffen, Strauss, Volker, Coder, Pragati S., Freyberger, Alexius, O’Connor, John C., Rauch, Martina, Renko, Kostja, Solano, Marize L. M., Andersson, Niklas, Blanck, Olivier, Ritz, Vera, Solecki, Roland

“…This publication summarizes discussions that were held during an international expert hearing organized by the German Federal Institute for Risk Assessment…”
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Comparative responses of rats and mice exposed to linear/branched, linear, or branched ammonium perfluorooctanoate (APFO) by Loveless, Scott E., Finlay, Carol, Everds, Nancy E., Frame, Steven R., Gillies, Peter J., O’Connor, John C., Powley, Charles R., Kennedy, Gerald L.

“…The purpose of this study was to compare the toxicity of linear/branched ammonium perfluorooctanoate (APFO) with that of linear and branched APFO…”
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Forests buffer against variations in precipitation by O'Connor, John C., Dekker, Stefan C., Staal, Arie, Tuinenburg, Obbe A., Rebel, Karin T., Santos, Maria J.

“…Atmospheric moisture recycling effectively increases the amount of usable water over land as the water can undergo multiple precipitation–evapotranspiration…”
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Coculture with Prostate Cancer Cells Alters Endoglin Expression and Attenuates Transforming Growth Factor-β Signaling in Reactive Bone Marrow Stromal Cells by O'Connor, John C., Farach-Carson, Mary C., Schneider, Charles J., Carson, Daniel D.

“…A dynamic interplay between prostate cancer cells and reactive bone stroma modulates growth of metastases within bone. We used microarray analysis to screen…”
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Evaluation of a 15-Day Screening Assay Using Intact Male Rats for Identifying Steroid Biosynthesis Inhibitors and Thyroid Modulators by O’Connor, John C., Frame, Steven R., Ladics, Gregory S.

“…An in vivo screening assay using intact adult male rats has been evaluated for its ability to detect four endocrine-active compounds (EACs) via oral (gavage)…”
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Evaluation of dietary dose administration as an alternative to oral gavage in the rodent uterotrophic and Hershberger assays by Markell, Lauren K., O'Connor, John C., Luo, Ruijuan, Klems, Joseph P., Sayers, Brian C., Mingoia, Robert T.

“…The rodent uterotrophic and Hershberger assays evaluate potential estrogenic and (anti)-androgenic effects, respectively. Both US EPA and OECD guidelines…”
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Two-day inhalation toxicity study of methyl iodide in the rat by Himmelstein, Matthew W., Kegelman, Thomas A., DeLorme, Michael P., Everds, Nancy E., O'Connor, John C., Kemper, Raymond A., Nabb, Diane L., Mileson, Beth E., Bevan, Christopher

“…The effects of inhaled methyl iodide (MeI) on clinical pathology parameters, glutathione (GSH) tissue levels, serum thyroid hormone and inorganic iodide…”
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The Toxicology of Perfluorooctanoate by Kennedy, Gerald L., Butenhoff, John L., Olsen, Geary W., O'Connor, John C., Seacat, Andrew M., Perkins, Roger G., Biegel, Lisa B., Murphy, Sandra R., Farrar, David G.

“…ABSTRACT PFOA is a peroxisome proliferator (PPAR agonist) and exerts morphological and biochemical effects characteristic of PPAR agonists. These effects…”
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Key Learnings from the Endocrine Disruptor Screening Program (EDSP) Tier 1 Rodent Uterotrophic and Hershberger Assays by Marty, M. Sue, O'Connor, John C.

“…In 2009, companies began screening compounds using the US Environmental Protection Agency's Endocrine Disruptor Screening Program (EDSP). EDSP has two tiers:…”
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Evaluation of Tier I Screening Approaches for Detecting Endocrine-Active Compounds (EACs) by O'Connor, John C., Cook, Jon C., Marty, M. Sue, Davis, Leonard G., Kaplan, A. Michael, Carney, Edward W.

“…In 1996, Congress passed legislation requiring the U.S. Environmental Protection Agency (EPA) to implement screening testing strategies for endocrine-active…”
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The reproductive toxicology of ammonium perfluorooctanoate (APFO) in the rat by Butenhoff, John L, Kennedy, Gerald L, Frame, Steven R, O’Connor, John C, York, Raymond G

“…Ammonium perfluorooctanoate (APFO) is a surfactant used primarily as an aid in processing various fluoropolymers. Many toxicology and epidemiological studies…”
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Key Lessons from Performance of the U.S. EPA Endocrine Disruptor Screening Program (EDSP) Tier 1 Male and Female Pubertal Assays by Stump, Donald G., O'Connor, John C., Lewis, Joseph M., Marty, M. Sue

“…The male and female pubertal assays, which are included in the U.S. Environmental Protection Agency's (EPA) Endocrine Disruptor Screening Program (EDSP) Tier 1…”
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Toxicological evaluation of sodium perfluorohexanoate by Loveless, Scott E, Slezak, Brian, Serex, Tessa, Lewis, Joseph, Mukerji, Pushkor, O’Connor, John C, Donner, E. Maria, Frame, Steven R, Korzeniowski, Stephen H, Buck, Robert C

“…Abstract Sodium perfluorohexanoate [NaPFHx, F(CF2 )5 CO2 Na, CAS#2923-26-4] was evaluated in acute, 90-day subchronic, one-generation reproduction,…”
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Mechanisms of Extrahepatic Tumor Induction by Peroxisome Proliferators in Male CD Rats by Biegel, Lisa B., Hurtt, Mark E., Frame, Steven R., O'Connor, John C., Cook, Jon C.

“…Wyeth-14,643 (WY) and ammonium perfluorooctanoate (C8) belong to a diverse class of compounds which have been shown to produce hepatic peroxisome proliferation…”
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Oral repeated-dose systemic and reproductive toxicity of 6:2 fluorotelomer alcohol in mice by Mukerji, Pushkor, Rae, Jessica Caverly, Buck, Robert C, O'Connor, John C

“…6:2 fluorotelomer alcohol (6:2 FTOH) was evaluated for potential systemic repeated-dose and reproductive toxicity in mice. 6:2 FTOH was administered by oral…”
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Evaluation of a 15-Day Screening Assay Using Intact Male Rats for Identifying Antiandrogens by O'Connor, John C., Frame, Steven R., Ladics, Gregory S.

“…An in vivo screening assay using intact adult male rats has been evaluated for its ability to detect six antiandrogenic compounds via oral administration. The…”
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