Search Results - "O'Yang, C"

Pharmacological characteristics of Ro 115–1240, a selective α1A/1L‐adrenoceptor partial agonist: a potential therapy for stress urinary incontinence by Blue, D.R., Daniels, D.V., Gever, J.R., Jett, M.F., O'Yang, C., Tang, H.M., Williams, T.J., Ford, A.P.D.W.

“…OBJECTIVE To describe the preclinical pharmacology of Ro 115–1240, a peripherally acting selective α1A/1L‐adrenoceptor (AR) partial agonist, compared with the…”
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Synthesis and Biological Evaluation of Ketorolac Analogs by J. Lopez, Francisco, Jett, Mary-Frances, M. Muchowski, Joseph, Nitzan, Dov, O'Yang, Counde

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RO1138452 and RO3244794: characterization of structurally distinct, potent and selective IP (prostacyclin) receptor antagonists by Bley, Keith R, Bhattacharya, Anindya, Daniels, Don V, Gever, Joel, Jahangir, Alam, O'Yang, Counde, Smith, Steven, Srinivasan, Dinesh, Ford, Anthony P D W, Jett, Mary‐Frances

“…Prostacyclin (PGI2) possesses various physiological functions, including modulation of nociception, inflammation and cardiovascular activity. Elucidation of…”
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Pharmacological characteristics of Ro 115–1240, a selective α 1A/1L ‐adrenoceptor partial agonist: a potential therapy for stress urinary incontinence by Blue, D.R., Daniels, D.V., Gever, J.R., Jett, M.F., O'Yang, C., Tang, H.M., Williams, T.J., Ford, A.P.D.W.

“…OBJECTIVE To describe the preclinical pharmacology of Ro 115–1240, a peripherally acting selective α 1A/1L ‐adrenoceptor (AR) partial agonist, compared with…”
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Convenient Method for the 3-Functionalization of Isoindazoles by Bunnell, Aaron, O'Yang, Counde, Petrica, Andra, Soth, Michael J.

“…The C-3 position of isoindazoles is readily functionalized by metalation with lithium diisopropylamide followed by reaction with a variety of electrophiles…”
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Characterization of the analgesic and anti-inflammatory activities of ketorolac and its enantiomers in the rat by Jett, M F, Ramesha, C S, Brown, C D, Chiu, S, Emmett, C, Voronin, T, Sun, T, O'Yang, C, Hunter, J C, Eglen, R M, Johnson, R M

“…The marked analgesic efficacy of ketorolac in humans, relative to other nonsteroidal anti-inflammatory drugs (NSAIDs), has lead to speculation as to whether…”
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Orally active prostacyclin-mimetic RS-93427: therapeutic potential in vascular occlusive disease associated with atherosclerosis by Willis, A L, Smith, D L, Vigo, C, Kluge, A, O'Yang, C, Kertesz, D, Wu, H

“…RS-93427 is a potent, orally active prostacyclin-mimetic that is very rapidly absorbed but with generally long-lived actions in most species. It has…”
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Pharmacological characteristics of Ro 115-1240, a selective alpha1A/1L-adrenoceptor partial agonist: a potential therapy for stress urinary incontinence by Blue, D R, Daniels, D V, Gever, J R, Jett, M F, O'Yang, C, Tang, H M, Williams, T J, Ford, A P D W

“…To describe the preclinical pharmacology of Ro 115-1240, a peripherally acting selective alpha1A/1L-adrenoceptor (AR) partial agonist, compared with the…”
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Synthesis of 10,10-difluorothromboxane A2, a potent and chemically stable thromboxane agonist by Fried, Josef, John, Varghese, Szwedo, Mitchell J, Chen, Chien Kuang, O'Yang, Counde, Morinelli, Thomas A, Okwu, Anselm K, Halushka, Perry V

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Stability of prostacyclin analogues: an unusual lack of reactivity in acid-catalyzed alkene hydration by MAGILL, A, O'YANG, C, POWELL, M. F

“…Prostacyclin analogue 5 undergoes specific acid-catalyzed hydration (kH+ = 1.9 x 10(-7)M-1 sec-1 at 25 degrees C) and a pH-independent oxidation reaction (k0 =…”
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Potent prostacyclin analogs based on the bicyclo[4.2.0]octane ring system by Kluge, Arthur F, Kertesz, Denis J, O-Yang, Counde, Wu, Helen Y

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Platelet aggregation inhibitory activity and vasodepressor activity of a series of bicyclo[3.2.0]hept-6-ylidene iminoxy alkanoic acids with modified lower side chains by O-Yang, C, Wu, H Y, Kertesz, D J, Kluge, A F, Wallach, M B, Willis, A L, Smith, D L, Chang, L F

“…Prostacyclin analogues derived from modification of the lower side chain of the bicyclo[3.2.0]hept-6-ylidene iminoxyacetic acid (1) were studied in inhibition…”
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Synthesis and platelet aggregation inhibition activity of a series of enantiomeric bicyclo[3.2.0]heptane-6-oximinoacetic acids (1) by O-Yang, C, Kertesz, D J, Kluge, A F, Kuenzler, P, Li, T T, Marx, M M, Bruno, J J, Chang, L F

“…Opening of racemic epoxide (3) with (3S)- or (3R)-dimethyl-3-(dimethyl-t-butylsilyloxy)oct-1-ynyl aluminum gave two regioisomers, which were separated…”
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