Search Results - "O'Toole, A G"

Innate and induced resistance mechanisms of bacterial biofilms by Anderson, G G, O'Toole, G A

“…Bacterial biofilms are highly recalcitrant to antibiotic treatment, which holds serious consequences for therapy of infections that involve biofilms. The…”
Get more information

Cyclic Di-GMP-Mediated Repression of Swarming Motility by Pseudomonas aeruginosa PA14 Requires the MotAB Stator by Kuchma, S. L, Delalez, N. J, Filkins, L. M, Snavely, E. A, Armitage, J. P, O'Toole, G. A

“…The second messenger cyclic diguanylate (c-di-GMP) plays a critical role in the regulation of motility. In Pseudomonas aeruginosa PA14, c-di-GMP inversely…”
Get full text

Rhamnolipids Modulate Swarming Motility Patterns of Pseudomonas aeruginosa by Caiazza, Nicky C, Shanks, Robert M Q, O'Toole, G A

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Prevalence of Streptococci and Increased Polymicrobial Diversity Associated with Cystic Fibrosis Patient Stability by Filkins, L. M, Hampton, T. H, Gifford, A. H, Gross, M. J, Hogan, D. A, Sogin, M. L, Morrison, H. G, Paster, B. J, O'Toole, G. A

“…Diverse microbial communities chronically colonize the lungs of cystic fibrosis patients. Pyrosequencing of amplicons for hypervariable regions in the 16S rRNA…”
Get full text

Minor Pilins of the Type IV Pilus System Participate in the Negative Regulation of Swarming Motility by Kuchma, S. L, Griffin, E. F, O'Toole, G. A

“…Pseudomonas aeruginosa exhibits distinct surface-associated behaviors, including biofilm formation, flagellum-mediated swarming motility, and type IV…”
Get full text

Keeping their options open : Acute versus persistent infections by FURUKAWA, S, KUCHMA, S. L, O'TOOLE, G. A

Get full text

Prevalence, conservation and functional analysis of Yersinia and Escherichia CRISPR regions in clinical Pseudomonas aeruginosa isolates by CADY, K. C, WHITE, A. S, HAMMOND, J. H, ABENDROTH, M. D, KARTHIKEYAN, R. S. G, LALITHA, P, ZEGANS, M. E, O'TOOLE, G. A

“…Here, we report the characterization of 122 Pseudomonas aeruginosa clinical isolates from three distinct geographical locations: Dartmouth Hitchcock Medical…”
Get full text

Alpha-Toxin Is Required for Biofilm Formation by Staphylococcus aureus by Caiazza, Nicky C, O'Toole, G A

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Biofilm Maintenance as an Active Process: Evidence that Biofilms Work Hard to Stay Put by Katharios-Lanwermeyer, Stefan, O'Toole, G A

“…Biofilm formation represents a critical strategy whereby bacteria can tolerate otherwise damaging environmental stressors and antimicrobial insults. While the…”
Get full text

A bacterial sense of touch: T4P retraction motor as a means of surface sensing by Pseudomonas aeruginosa PA14 by Geiger, C J, Wong, G C L, O'Toole, G A

“…Most microbial cells found in nature exist in matrix-covered, surface-attached communities known as biofilms. This mode of growth is initiated by the ability…”
Get more information

Iron and CF-related anemia: Expanding clinical and biochemical relationships by Gifford, A.H., Miller, S.D., Jackson, B.P., Hampton, T.H., O'Toole, G.A., Stanton, B.A., Parker, H.W.

“…Introduction This cross‐sectional study was conducted to assess the relationship between iron levels in the plasma and sputum of cystic fibrosis (CF) patients…”
Get full text

Evidence for the Type IV Pilus Retraction Motor PilT as a Component of the Surface Sensing System in Pseudomonas aeruginosa by Geiger, C J, O'Toole, G A

“…Biofilm formation begins when bacteria contacting a surface induce cellular changes to become better adapted for surface growth. One of the first changes to…”
Get full text

Green fluorescent protein as a marker for Pseudomonas spp by Bloemberg, G.V, O'Toole, G.A, Lugtenberg, B.J.J, Kolter, R

“…The development of sensitive methods for observing individual bacterial cells in a population in experimental models and natural environments, such as in…”
Get full text

Pseudomonas aeruginosa Uses c-di-GMP Phosphodiesterases RmcA and MorA To Regulate Biofilm Maintenance by Katharios-Lanwermeyer, S, Whitfield, G B, Howell, P L, O'Toole, G A

“…While the early stages of biofilm formation have been well characterized, less is known about the requirements for to maintain a mature biofilm. We utilized a…”
Get full text

Binding of GTP to BifA is required for the production of Pel-dependent biofilms in Pseudomonas aeruginosa by Van Loon, Jaime C, Whitfield, Gregory B, Wong, Nicole, O'Neal, Lindsey, Henrickson, Amy, Demeler, Borries, O'Toole, G A, Parsek, Matthew R, Howell, P Lynne

“…c-di-GMP is the most common cyclic dinucleotide used by bacteria to regulate phenotypes such as motility, biofilm formation, virulence factor production, cell…”
Get full text

Serial analysis of the gut and respiratory microbiome in cystic fibrosis in infancy: interaction between intestinal and respiratory tracts and impact of nutritional exposures by Madan, J C, Koestler, D C, Stanton, B A, Davidson, L, Moulton, L A, Housman, M L, Moore, J H, Guill, M F, Morrison, H G, Sogin, M L, Hampton, T H, Karagas, M R, Palumbo, P E, Foster, J A, Hibberd, P L, O'Toole, G A

“…Pulmonary damage caused by chronic colonization of the cystic fibrosis (CF) lung by microbial communities is the proximal cause of respiratory failure. While…”
Get full text

Microbial Biofilms: from Ecology to Molecular Genetics by Davey, M E, O'toole, G A

“…Article Usage Stats Services MMBR Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Initiation of biofilm formation in Pseudomonas fluorescens WCS365 proceeds via multiple, convergent signalling pathways: a genetic analysis by O'Toole, George A., Kolter, Roberto

“…Populations of surface‐attached microorganisms comprising either single or multiple species are commonly referred to as biofilms. Using a simple assay for the…”
Get full text

Flagellar and twitching motility are necessary for Pseudomonas aeruginosa biofilm development by O'Toole, George A., Kolter, Roberto

“…The formation of complex bacterial communities known as biofilms begins with the interaction of planktonic cells with a surface in response to appropriate…”
Get full text

A genetic basis for Pseudomonas aeruginosa biofilm antibiotic resistance by O'Toole, George A, Mah, Thien-Fah, Pitts, Betsey, Pellock, Brett, Walker, Graham C, Stewart, Philip S

“…Biofilms are surface-attached microbial communities with characteristic architecture and phenotypic and biochemical properties distinct from their…”
Get full text