Search Results - "O'Sullivan, Brendan J"

Langerhans cells are precommitted to immune tolerance induction by Shklovskaya, Elena, O’Sullivan, Brendan J, Ng, Lai Guan, Roediger, Ben, Thomas, Ranjeny, Weninger, Wolfgang, Fazekas de St Groth, Barbara

“…Antigen-dependent interactions between T lymphocytes and dendritic cells (DCs) can produce two distinct outcomes: tolerance and immunity. It is generally…”
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A Methodological Approach to Identify Natural Compounds with Antifibrotic Activity and the Potential to Treat Pulmonary Fibrosis Using Single-Cell Sequencing and Primary Human Lung Macrophages by Apte, Simon H, Groves, Penny L, Tan, Maxine E, Lutzky, Viviana P, de Silva, Tharushi, Monteith, Joshua N, Yerkovich, Stephanie T, O’Sullivan, Brendan J, Davis, Rohan A, Chambers, Daniel C

“…Idiopathic pulmonary fibrosis (IPF) is the most common and lethal form of the interstitial pneumonias. The cause of the disease is unknown, and new therapies…”
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Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype-positive rheumatoid arthritis patients by Benham, Helen, Nel, Hendrik J, Law, Soi Cheng, Mehdi, Ahmed M, Street, Shayna, Ramnoruth, Nishta, Pahau, Helen, Lee, Bernett T, Ng, Jennifer, Brunck, Marion E G, Hyde, Claire, Trouw, Leendert A, Dudek, Nadine L, Purcell, Anthony W, O'Sullivan, Brendan J, Connolly, John E, Paul, Sanjoy K, Lê Cao, Kim-Anh, Thomas, Ranjeny

“…In animals, immunomodulatory dendritic cells (DCs) exposed to autoantigen can suppress experimental arthritis in an antigen-specific manner. In rheumatoid…”
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RelB-Deficient Dendritic Cells Promote the Development of Spontaneous Allergic Airway Inflammation by Nair, Prema M, Starkey, Malcolm R, Haw, Tatt Jhong, Ruscher, Roland, Liu, Gang, Maradana, Muralidhara R, Thomas, Ranjeny, O'Sullivan, Brendan J, Hansbro, Philip M

“…RelB is a member of the NF-κB family, which is essential for dendritic cell (DC) function and maturation. However, the contribution of RelB to the development…”
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IL-1 beta breaks tolerance through expansion of CD25+ effector T cells by O'Sullivan, Brendan J, Thomas, Helen E, Pai, Saparna, Santamaria, Pere, Iwakura, Yoichiro, Steptoe, Raymond J, Kay, Thomas W H, Thomas, Ranjeny

“…IL-1 is a key proinflammatory driver of several autoimmune diseases including juvenile inflammatory arthritis, diseases with mutations in the NALP/cryopyrin…”
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PD-L1- and calcitriol-dependent liposomal antigen-specific regulation of systemic inflammatory autoimmune disease by Galea, Ryan, Nel, Hendrik J, Talekar, Meghna, Liu, Xiao, Ooi, Joshua D, Huynh, Megan, Hadjigol, Sara, Robson, Kate J, Ting, Yi Tian, Cole, Suzanne, Cochlin, Karyn, Hitchcock, Shannon, Zeng, Bijun, Yekollu, Suman, Boks, Martine, Goh, Natalie, Roberts, Helen, Rossjohn, Jamie, Reid, Hugh H, Boyd, Ben J, Malaviya, Ravi, Shealy, David J, Baker, Daniel G, Madakamutil, Loui, Kitching, A Richard, O'Sullivan, Brendan J, Thomas, Ranjeny

“…Autoimmune diseases resulting from MHC class II-restricted autoantigen-specific T cell immunity include the systemic inflammatory autoimmune conditions…”
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Autoimmune-Mediated Thymic Atrophy Is Accelerated but Reversible in RelB-Deficient Mice by O'Sullivan, Brendan J, Yekollu, Suman, Ruscher, Roland, Mehdi, Ahmed M, Maradana, Muralidhara Rao, Chidgey, Ann P, Thomas, Ranjeny

“…Polymorphisms impacting thymic function may decrease peripheral tolerance and hasten autoimmune disease. The NF-κB transcription factor subunit, RelB, is…”
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Immunotherapy with costimulatory dendritic cells to control autoimmune inflammation by O'Sullivan, Brendan J, Pai, Saparna, Street, Shayna, An, Xiayou, MacDonald, Kelli P A, Wong, Michele, Strutton, Geoffrey, Gerondakis, Steve, Steptoe, Raymond J, de St Groth, Barbara Fazekas, Hill, Geoffrey R, Thomas, Ranjeny

“…Costimulation-deficient dendritic cells (DCs) prevent autoimmune disease in mouse models. However, autoimmune-prone mice and humans fail to control expansion…”
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Abnormal NF-kappa B function characterizes human type 1 diabetes dendritic cells and monocytes by Mollah, Zia U A, Pai, Saparna, Moore, Craig, O'Sullivan, Brendan J, Harrison, Matthew J, Peng, Judy, Phillips, Karen, Prins, Johannes B, Cardinal, John, Thomas, Ranjeny

“…Dendritic cell (DC) differentiation is abnormal in type 1 diabetes mellitus (T1DM). However, the nature of the relationship between this abnormality and…”
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Targeted delivery of curcumin for treating type 2 diabetes by Maradana, Muralidhara Rao, Thomas, Ranjeny, O'Sullivan, Brendan J.

“…Type 2 diabetes is a chronic condition in which cells have reduced insulin signalling, leading to hyperglycemia and long‐term complications, including heart,…”
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Itaconate controls the severity of pulmonary fibrosis by Ogger, Patricia P, Albers, Gesa J, Hewitt, Richard J, O'Sullivan, Brendan J, Powell, Joseph E, Calamita, Emily, Ghai, Poonam, Walker, Simone A, McErlean, Peter, Saunders, Peter, Kingston, Shaun, Molyneaux, Philip L, Halket, John M, Gray, Robert, Chambers, Daniel C, Maher, Toby M, Lloyd, Clare M, Byrne, Adam J

“…Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease in which airway macrophages (AMs) play a key role. Itaconate has emerged as a mediator of…”
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T cells signaled by NF-kappa B- dendritic cells are sensitized not anergic to subsequent activation by Thompson, Angus G, O'Sullivan, Brendan J, Beamish, Heather, Thomas, Ranjeny

“…Paradoxically, while peripheral self-tolerance exists for constitutively presented somatic self Ag, self-peptide recognized in the context of MHC class II has…”
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RelB Nuclear Translocation Regulates B Cell MHC Molecule, CD40 Expression, and Antigen-Presenting Cell Function by O'Sullivan, Brendan J., Kelli P. A. Mac Donald, Pettit, Allison R., Thomas, Ranjeny

“…Mice with targeted RelB mutations demonstrated an essential role for RelB in immune responses and in myeloid dendritic cell differentiation. Human studies…”
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RelB Nuclear Translocation Mediated by C-Terminal Activator Regions of Epstein-Barr Virus-Encoded Latent Membrane Protein 1 and Its Effect on Antigen-Presenting Function in B Cells by Pai, Saparna, O'Sullivan, Brendan J, Cooper, Leanne, Thomas, Ranjeny, Khanna, Rajiv

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Pneumococcal conjugate vaccine-induced regulatory T cells suppress the development of allergic airways disease by Thorburn, Alison N, O'Sullivan, Brendan J, Thomas, Ranjeny, Kumar, Rakesh K, Foster, Paul S, Gibson, Peter G, Hansbro, Philip M

“…Infections with some bacteria, including Streptococcus pneumoniae, have been associated with a reduced incidence of asthma. Components of S pneumoniae may have…”
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Dynamics of human monocytes and airway macrophages during healthy aging and after transplant by Byrne, Adam J, Powell, Joseph E, O'Sullivan, Brendan J, Ogger, Patricia P, Hoffland, Ashley, Cook, James, Bonner, Katie L, Hewitt, Richard J, Wolf, Simone, Ghai, Poonam, Walker, Simone A, Lukowski, Samuel W, Molyneaux, Philip L, Saglani, Sejal, Chambers, Daniel C, Maher, Toby M, Lloyd, Clare M

“…The ontogeny of airway macrophages (AMs) in human lung and their contribution to disease are poorly mapped out. In mice, aging is associated with an increasing…”
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Monocyte-derived DC primed with TLR agonists secrete IL-12p70 in a CD40-dependent manner under hyperthermic conditions by PENG, Judy C, HYDE, Claire, PAI, Saparna, O'SULLIVAN, Brendan J, NIELSEN, Lars K, THOMAS, Ranjeny

“…Fever is an evolutionarily conserved mechanism to improve survival during infection. Previous studies have shown that feverlike temperatures directly enhance…”
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Chromosomal structure of the human TYRP1 and TYRP2 loci and comparison of the tyrosinase-related protein gene family by STURM, R. A, O'SULLIVAN, B. J, BOX, N. F, SMITH, A. G, SMIT, S. E, PUTTICK, E. R. J, PARSONS, P. G, DUNN, I. S

“…The structures of the human tyrosinase-related protein genes TYRP1 and TYRP2 have been determined and compared with that of the tyrosinase gene (TYR). The…”
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Targeted delivery of curcumin for treating type 2 diabetes : Curcumin: Recent Insights, Novel Developments, New Challenges by MURALIDHARA RAO MARADANA, THOMAS, Ranjeny, O'SULLIVAN, Brendan J

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T Cells Signaled by NF- Kappa B super(-) Dendritic Cells Are Sensitized Not Anergic to Subsequent Activation by Thompson, Angus G, O'Sullivan, Brendan J, Beamish, Heather, Thomas, Ranjeny

“…Paradoxically, while peripheral self-tolerance exists for constitutively presented somatic self Ag, self-peptide recognized in the context of MHC class II has…”
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