Search Results - "O'Steen, Shyril"

Venetoclax Synergizes with Radiotherapy for Treatment of B-cell Lymphomas by O'Steen, Shyril, Green, Damian J, Gopal, Ajay K, Orozco, Johnnie J, Kenoyer, Aimee L, Lin, Yukang, Wilbur, D Scott, Hamlin, Donald K, Fisher, Darrell R, Hylarides, Mark D, Gooley, Theodore A, Waltman, Amelia, Till, Brian G, Press, Oliver W

“…Constitutive B-cell receptor signaling leads to overexpression of the antiapoptotic BCL-2 protein and is implicated in the pathogenesis of many types of B-cell…”
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Thermal Acclimation Effects Differ between Voluntary, Maximum, and Critical Swimming Velocities in Two Cyprinid Fishes by O'Steen, Shyril, Bennett, Albert F.

“…Temperature acclimation may be a critical component of the locomotor physiology and ecology of ectothermic animals, particularly those living in eurythermal…”
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The α-emitter astatine-211 targeted to CD38 can eradicate multiple myeloma in a disseminated disease model by O'Steen, Shyril, Comstock, Melissa L., Orozco, Johnnie J., Hamlin, Donald K., Wilbur, D. Scott, Jones, Jon C., Kenoyer, Aimee, Nartea, Margaret E., Lin, Yukang, Miller, Brian W., Gooley, Theodore A., Tuazon, Sherilyn A., Till, Brian G., Gopal, Ajay K., Sandmaier, Brenda M., Press, Oliver W., Green, Damian J.

“…Minimal residual disease (MRD) has become an increasingly prevalent and important entity in multiple myeloma (MM). Despite deepening responses to frontline…”
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Development of [211At]astatine-based anti-CD123 radioimmunotherapy for acute leukemias and other CD123+ malignancies by Laszlo, George S., Orozco, Johnnie J., Kehret, Allie R., Lunn, Margaret C., Huo, Jenny, Hamlin, Donald K., Scott Wilbur, D., Dexter, Shannon L., Comstock, Melissa L., O’Steen, Shyril, Sandmaier, Brenda M., Green, Damian J., Walter, Roland B.

“…Radioimmunotherapy (RIT) has long been pursued to improve outcomes in acute leukemia and higher-risk myelodysplastic syndrome (MDS). Of increasing interest are…”
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CD38-bispecific antibody pretargeted radioimmunotherapy for multiple myeloma and other B-cell malignancies by Green, Damian J., O'Steen, Shyril, Lin, Yukang, Comstock, Melissa L., Kenoyer, Aimee L., Hamlin, Donald K., Wilbur, D. Scott, Fisher, Darrell R., Nartea, Margaret, Hylarides, Mark D., Gopal, Ajay K., Gooley, Theodore A., Orozco, Johnnie J., Till, Brian G., Orcutt, Kelly D., Wittrup, K. Dane, Press, Oliver W.

“…Pretargeted radioimmunotherapy (PRIT) has demonstrated remarkable efficacy targeting tumor antigens, but immunogenicity and endogenous biotin blocking may…”
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CD8+ chimeric antigen receptor T cells manufactured in absence of CD4+ cells exhibit hypofunctional phenotype by Lee, Sang Yun, Lee, Dong Hoon, Sun, Wei, Cervantes-Contreras, Francisco, Basom, Ryan S, Wu, Feinan, Liu, Si, Rai, Richa, Mirzaei, Hamid R, O’Steen, Shyril, Green, Damian J, Shadman, Mazyar, Till, Brian G

“…BackgroundCell culture conditions during manufacturing can impact the clinical efficacy of chimeric antigen receptor (CAR) T cell products. Production methods…”
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Preclinical Optimization of a CD20-specific Chimeric Antigen Receptor Vector and Culture Conditions by Lee, Sang Yun, Olsen, Philip, Lee, Dong Hoon, Kenoyer, Aimee L, Budde, Lihua E, O'Steen, Shyril, Green, Damian J, Heimfeld, Shelly, Jensen, Michael C, Riddell, Stanley R, Press, Oliver W, Till, Brian G

“…Chimeric antigen receptor (CAR)-based adoptive T-cell therapy is a highly promising treatment for lymphoid malignancies, and CD20 is an ideal target antigen…”
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Therapy of Myeloid Leukemia using Novel Bispecific Fusion Proteins Targeting CD45 and 90Y-DOTA by Orozco, Johnnie J., Kenoyer, Aimee L., Lin, Yukang, O'Steen, Shyril, Guel, Rosario, Nartea, Margaret E., Hernandez, Alexandra H., Hylarides, Mark D., Fisher, Darrell R., Balkin, Ethan R., Hamlin, Donald K., Wilbur, D. Scott, Orcutt, Kelly D., Wittrup, K. Dane, Green, Damian J., Gopal, Ajay K., Till, Brian G., Sandmaier, Brenda, Press, Oliver W., Pagel, John M.

“…Abstract Pretargeted radioimmunotherapy (PRIT) has been investigated as a multi-step approach to decrease relapse and toxicity for high-risk acute myeloid…”
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Comparative Analysis of Bispecific Antibody and Streptavidin-Targeted Radioimmunotherapy for B-cell Cancers by Green, Damian J, Frayo, Shani L, Lin, Yukang, Hamlin, Donald K, Fisher, Darrell R, Frost, Sofia H L, Kenoyer, Aimee L, Hylarides, Mark D, Gopal, Ajay K, Gooley, Theodore A, Orozco, Johnnie J, Till, Brian G, O'Steen, Shyril, Orcutt, Kelly D, Wilbur, D Scott, Wittrup, K Dane, Press, Oliver W

“…Streptavidin (SA)-biotin pretargeted radioimmunotherapy (PRIT) that targets CD20 in non-Hodgkin lymphoma (NHL) exhibits remarkable efficacy in model systems,…”
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BCMA-Directed Low Dose Alpha-Emitter Therapy Eliminates Minimal Residual Disease in a Multiple Myeloma Mouse Xenograft Model by Comstock, Melissa L, O'Steen, Shyril, Lin, Yukang, Hamlin, Donald, Wilbur, D Scott, Orozco, Johnnie J., Storb, Rainer F., Walter, Roland B., Ataca Atilla, Pinar, Till, Brian G, Hill, Geoffrey R, Sandmaier, Brenda M., Green, Damian J

“…BACKGROUND: Unprecedented reductions in multiple myeloma (MM) tumor burden after treatment with B cell maturation antigen (BCMA) directed bispecific T-cell…”
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Dynamically honest displays: courtship locomotor performance indicates survival in guppies by O'Steen, Shyril, Eby, Stephanie L, Bunce, John A

“…1. The indicator theory of sexual selection suggests that mating displays honestly signal aspects of fitness. While rarely studied, kinematic (locomotor)…”
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Development of Astatine-211 (211At)-Based Anti-CD123 Radioimmunotherapy for Acute Leukemias and Other CD123+ Hematologic Malignancies by Laszlo, George S., Orozco, Johnnie J., Kehret, Allie R., Lunn, Margaret C., Hamlin, Donald K., Wilbur, D. Scott, Dexter, Shannon L., Comstock, Melissa C., O'Steen, Shyril, Green, Damian J., Walter, Roland B.

“…Background: Radioimmunotherapy (RIT) has long been pursued to improve outcomes in acute leukemia. Of current interest are alpha-particle emitting radionuclides…”
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RAPID EVOLUTION OF ESCAPE ABILITY IN TRINIDADIAN GUPPIES (POECILIA RETICULATA) by O'Steen, Shyril, Cullum, Alistair J., Bennett, Albert F.

“…Predators are widely assumed to create selection that shapes the evolution of prey escape abilities. However, this assumption is difficult to test directly due…”
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The Alpha Emitter Astatine-211 Targeted to CD38 Can Eradicate Multiple Myeloma in Minimal Residual Disease Models by O'Steen, Shyril, Comstock, Melissa C., Orozco, Johnnie J., Hamlin, Donald K., Wilbur, D. Scott, Jones, Jon, Kenoyer, Aimee, Nartea, Margaret E., Lin, Yukang, Miller, Brian W., Tuazon, Sherilyn A., Till, Brian G., Gopal, Ajay K., Sandmaier, Brenda M., Press, Oliver W., Green, Damian J.

“…Introduction Multiple myeloma (MM) is considered incurable but patients achieving minimal-residual disease (MRD) negative status following treatment have…”
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Venetoclax Synergizes with Radiation Therapy for Treatment of B-Cell Lymphomas by O'Steen, Shyril, Waltman, Amelia, Booth, Garrett, Kenoyer, Aimee L, Nartea, Margaret, Mullins, Chelsea, Lin, Yukang, Lee, Sang Yun, Hylarides, Mark D, Orozco, Johnnie J., Green, Damian J., Gopal, Ajay K., Till, Brian G., Press, Oliver W

“…Introduction: An estimated 19,970 Americans died of non-Hodgkin lymphoma (NHL) in 2015, with diffuse large B-cell lymphoma (DLBCL) accounting for roughly 30%…”
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Novel Bispecific Antibody Targeting CD45 and 90Y-DOTA Is Effective Therapy for Acute Myeloid Leukemia in Preclinical Murine Models by Orozco, Johnnie J., Kenoyer, Aimee, Lin, Yukang, Fisher, Darrell R., Hamlin, Donald K., Wilbur, D. Scott, Hernandez, Alexandra, Guel, Rosario, Nartea, Margaret E., O'Steen, Shyril, Hylarides, Mark D, Till, Brian G, Green, Damian J., Gopal, Ajay K., Orcutt, Kelly D, Wittrup, Karl Dane, Sandmaier, Brenda M., Pagel, John M., Press, Oliver W.

“…Background : Acute myeloid leukemia (AML) is a heterogeneous disease with a variety of chromosomal and molecular aberrations, rendering AML a challenging…”
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A Novel Bispecific CD38 Antibody Eradicates Multiple Myeloma in a Mouse Model Following Yttrium-90-DOTA Capture by Green, Damian J, Jones, Jon C, Lin, Yukang, Frayo, Shani L., Kenoyer, Aimee L, O'Steen, Shyril, Peters, Arianna, Frost, Sofia HL, Orozco, Johnnie J., Gopal, Ajay K, Hylarides, Mark D, Fisher, Darrell R, Sandmaier, Brenda M., Till, Brian G., Balkin, Ethan R, Hamlin, Don K, Wilbur, D.Scott, Orcutt, Kelly D, Wittrup, K. Dane, Press, Oliver W.

“…Despite high rates of initial response to immunomodulatory agents and proteasome inhibitors, the vast majority patients living with multiple myeloma (MM) will…”
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Therapy of Myeloid Leukemia using Novel Bispecific Fusion Proteins Targeting CD45 and 90 Y-DOTA by Orozco, Johnnie J, Kenoyer, Aimee L, Lin, Yukang, O'Steen, Shyril, Guel, Rosario, Nartea, Margaret E, Hernandez, Alexandra H, Hylarides, Mark D, Fisher, Darrell R, Balkin, Ethan R, Hamlin, Donald K, Wilbur, D Scott, Orcutt, Kelly D, Wittrup, K Dane, Green, Damian J, Gopal, Ajay K, Till, Brian G, Sandmaier, Brenda, Press, Oliver W, Pagel, John M

“…Pretargeted radioimmunotherapy (PRIT) has been investigated as a multi-step approach to decrease relapse and toxicity for high-risk acute myeloid leukemia…”
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Embryonic Temperature Affects Metabolic Compensation and Thyroid Hormones in Hatchling Snapping Turtles by O'Steen, Shyril, Janzen, Fredric J.

“…Temperature acclimation of adult vertebrates typically induces changes in metabolic physiology. During early development, such metabolic compensation might…”
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RAPID EVOLUTION OF ESCAPE ABILITY IN TRINIDADIAN GUPPIES (POECILIA RETICULATA) by O'Steen, Shyril, Cullum, Alistair J, Bennett, Albert F

“…Predators are widely assumed to create selection that shapes the evolution of prey escape abilities. However, this assumption is difficult to test directly due…”
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