Search Results - "O'Shea Murray, Valerie L"
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The molecular coupling between substrate recognition and ATP turnover in a AAA+ hexameric helicase loader
Published in eLife (26-05-2021)“…In many bacteria and eukaryotes, replication fork establishment requires the controlled loading of hexameric, ring-shaped helicases around DNA by AAA+(ATPases…”
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Physical Basis for the Loading of a Bacterial Replicative Helicase onto DNA
Published in Molecular cell (04-04-2019)“…In cells, dedicated AAA+ ATPases deposit hexameric, ring-shaped helicases onto DNA to initiate chromosomal replication. To better understand the mechanisms by…”
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Structural Basis for Finding OG Lesions and Avoiding Undamaged G by the DNA Glycosylase MutY
Published in ACS chemical biology (17-01-2020)“…The adenine glycosylase MutY selectively initiates repair of OG:A lesions and, by comparison, avoids G:A mispairs. The ability to distinguish these closely…”
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Journal Article