Search Results - "O'Shea, John J."

JAK and STAT Signaling Molecules in Immunoregulation and Immune-Mediated Disease by O'Shea, John J., Plenge, Robert

“…The discovery of the Janus kinase (JAK)-signal transducer and activator of transcripton (STAT) signaling pathway, a landmark in cell biology, provided a simple…”
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Janus kinase-targeting therapies in rheumatology: a mechanisms-based approach by Tanaka, Yoshiya, Luo, Yiming, O’Shea, John J., Nakayamada, Shingo

“…The four Janus kinase (JAK) proteins and seven signal transducer and activator of transcription (STAT) transcription factors mediate intracellular signal…”
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A Decade of JAK Inhibitors: What Have We Learned and What May Be the Future? by Liu, Christine, Kieltyka, Jacqueline, Fleischmann, Roy, Gadina, Massimo, O’Shea, John J.

“…The discovery of cytokines and their role in immune and inflammatory disease led to the development of a plethora of targeted biologic therapies. Later,…”
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Type I/II cytokines, JAKs, and new strategies for treating autoimmune diseases by Schwartz, Daniella M., Bonelli, Michael, Gadina, Massimo, O'Shea, John J.

“…Key Points Cytokines are major drivers of autoimmunity, and targeting cytokines has revolutionized the treatment of rheumatologic diseases Despite their…”
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Mechanisms of Jak/STAT signaling in immunity and disease by Villarino, Alejandro V, Kanno, Yuka, Ferdinand, John R, O'Shea, John J

“…More than two decades ago, experiments on the antiviral mechanisms of IFNs led to the discovery of JAKs and their downstream effectors, the STAT proteins. This…”
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JAKing up immunity by Gadina, Massimo, O'Shea, John J

“…Janus kinase (JAK) inhibitors improve antitumor responses…”
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JAK inhibition as a therapeutic strategy for immune and inflammatory diseases by Schwartz, Daniella M., Kanno, Yuka, Villarino, Alejandro, Ward, Michael, Gadina, Massimo, O'Shea, John J.

“…Key Points Despite their success, conventional and biologic disease-modifying antirheumatic drugs are not effective in all patients. First-generation Janus…”
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JAK inhibition as a therapeutic strategy for immune and inflammatory diseases by Schwartz, Daniella M, Kanno, Yuka, Villarino, Alejandro, Ward, Michael, Gadina, Massimo, O'Shea, John J

“…This corrects the article DOI: 10.1038/nrd.2017.201…”
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Selective Janus kinase inhibitors come of age by O’Shea, John J., Gadina, Massimo

“…Janus kinase (JAK) inhibitors (jakinibs) that target downstream signalling by a large range of cytokines are effective in treating autoimmune and rheumatic…”
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The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention by O'Shea, John J, Schwartz, Daniella M, Villarino, Alejandro V, Gadina, Massimo, McInnes, Iain B, Laurence, Arian

“…The Janus kinase (JAK)-signal transducer of activators of transcription (STAT) pathway is now recognized as an evolutionarily conserved signaling pathway…”
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Janus kinase inhibitors in autoimmune diseases by O'Shea, John J, Kontzias, Apostolos, Yamaoka, Kunihiro, Tanaka, Yoshiya, Laurence, Arian

“…Biological therapies directed at proinflammatory cytokines have irrevocably changed the landscape of treatment of rheumatoid arthritis (RA) and other…”
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Mechanisms Underlying Lineage Commitment and Plasticity of Helper CD4⁺ T Cells by O'Shea, John J., Paul, William E.

“…CD4⁺ T cells are critical for host defense but are also major drivers of immune-mediated disease. These T cells specialize to become distinct subsets and…”
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Janus kinases in immune cell signaling by Ghoreschi, Kamran, Laurence, Arian, O'Shea, John J

“…The Janus family kinases (Jaks), Jak1, Jak2, Jak3, and Tyk2, form one subgroup of the non-receptor protein tyrosine kinases. They are involved in cell growth,…”
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Neuropeptide CGRP Limits Group 2 Innate Lymphoid Cell Responses and Constrains Type 2 Inflammation by Nagashima, Hiroyuki, Mahlakõiv, Tanel, Shih, Han-Yu, Davis, Fred P., Meylan, Francoise, Huang, Yuefeng, Harrison, Oliver J., Yao, Chen, Mikami, Yohei, Urban, Joseph F., Caron, Kathleen M., Belkaid, Yasmine, Kanno, Yuka, Artis, David, O’Shea, John J.

“…Innate lymphocytes maintain tissue homeostasis at mucosal barriers, with group 2 innate lymphoid cells (ILC2s) producing type 2 cytokines and controlling…”
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JAKs and STATs in Immunity, Immunodeficiency, and Cancer by O'Shea, John J, Holland, Steven M, Staudt, Louis M

“…A large number of cytokines signal through the JAK–STAT pathway. Abnormal function of this pathway may lead to a variety of diseases. Targeting the defects in…”
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JAK-STAT signaling in human disease: From genetic syndromes to clinical inhibition by Luo, Yiming, Alexander, Madison, Gadina, Massimo, O’Shea, John J., Meylan, Francoise, Schwartz, Daniella M.

“…Since its discovery, the Janus kinase-signal transduction and activation of transcription (JAK-STAT) pathway has become recognized as a central mediator of…”
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SnapShot: Jak-STAT Signaling II by Villarino, Alejandro V., Gadina, Massimo, O’Shea, John J., Kanno, Yuka

“…The JAK-STAT pathway is an evolutionarily conserved signal transduction paradigm, providing mechanisms for rapid receptor-to-nucleus communication and…”
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Developmental Acquisition of Regulomes Underlies Innate Lymphoid Cell Functionality by Shih, Han-Yu, Sciumè, Giuseppe, Mikami, Yohei, Guo, Liying, Sun, Hong-Wei, Brooks, Stephen R., Urban, Joseph F., Davis, Fred P., Kanno, Yuka, O’Shea, John J.

“…Innate lymphoid cells (ILCs) play key roles in host defense, barrier integrity, and homeostasis and mirror adaptive CD4+ T helper (Th) cell subtypes in both…”
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Cytokine Signaling Modules in Inflammatory Responses by O'Shea, John J., Murray, Peter J.

“…Cytokine signaling via a restricted number of Jak-Stat pathways positively and negatively regulates all cell types involved in the initiation, propagation, and…”
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Interleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation by Laurence, Arian, Tato, Cristina M., Davidson, Todd S., Kanno, Yuka, Chen, Zhi, Yao, Zhengju, Blank, Rebecca B., Meylan, Françoise, Siegel, Richard, Hennighausen, Lothar, Shevach, Ethan M., O'Shea, John J.

“…Recent work has identified a new subset of effector T cells that produces interleukin (IL)-17 known as T helper 17 (Th17) cells, which is involved in the…”
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