Search Results - "O'Rourke, Stephen T."

Vascular effects of apelin: Mechanisms and therapeutic potential by Mughal, Amreen, O'Rourke, Stephen T.

“…Apelin is a vasoactive peptide and is an endogenous ligand for APJ receptors, which are widely expressed in blood vessels, heart, and cardiovascular regulatory…”
Get full text

Activation of Large Conductance, Calcium-Activated Potassium Channels by Nitric Oxide Mediates Apelin-Induced Relaxation of Isolated Rat Coronary Arteries by Mughal, Amreen, Sun, Chengwen, O'Rourke, Stephen T

“…Apelin increases coronary blood flow, cardiac contractility, and cardiac output. Based on these favorable hemodynamic effects, apelin and apelin-like analogs…”
Get more information

Angiotensin-(1-7) attenuates angiotensin II-induced cardiac hypertrophy via a Sirt3-dependent mechanism by Guo, Lirong, Yin, Ankang, Zhang, Qi, Zhong, Tiecheng, O'Rourke, Stephen T, Sun, Chengwen

“…The objectives of the present study were to investigate the effect of ANG-(1-7) on the development of cardiac hypertrophy and to identify the intracellular…”
Get more information

Intravenous administration of apeling-13 induces a depressor response by releasing an unidentified substance by Yao, Fanrong, Niloy, Sayeman Islam, Shen, Yue, Zhang, Qi, O'Rourke, Stephen T., Sun, Chengwen

“…Apelin and APJ receptor play an important role in the regulating cardiovascular function; however, conflicting results have been reported regarding the effect…”
Get full text

Apelin-Induced Relaxation of Coronary Arteries Is Impaired in a Model of Second-Hand Cigarette Smoke Exposure by Anto, Santo, Sathish, Venkatachalem, Sun, Chengwen, O'Rourke, Stephen T.

“…Apelin, an endogenous ligand for APJ receptors, causes nitric oxide (NO)-dependent relaxation of coronary arteries. Little is known about the effects of…”
Get full text

Apelin-13 inhibits large-conductance Ca2+-activated K+ channels in cerebral artery smooth muscle cells via a PI3-kinase dependent mechanism by Modgil, Amit, Guo, Lirong, O'Rourke, Stephen T, Sun, Chengwen

“…Apelin-13 causes vasoconstriction by acting directly on APJ receptors in vascular smooth muscle (VSM) cells; however, the ionic mechanisms underlying this…”
Get full text

Apelin Does Not Impair Coronary Artery Relaxation Mediated by Nitric Oxide-Induced Activation of BKCa Channels by Mughal, Amreen, Sun, Chengwen, O’Rourke, Stephen T.

“…Apelin-APJ receptor signaling regulates vascular tone in cerebral and peripheral arteries. We recently reported that apelin inhibits BK Ca channel function in…”
Get full text

Apelin Reduces Nitric Oxide–Induced Relaxation of Cerebral Arteries by Inhibiting Activation of Large-Conductance, Calcium-Activated K Channels by Mughal, Amreen, Sun, Chengwen, OʼRourke, Stephen T

“…Activation of the apelin/APJ receptor signaling system causes endothelium-dependent and nitric oxide (NO)–dependent relaxation in several peripheral arteries…”
Get full text

Large-conductance, calcium-activated potassium channels: structural and functional implications by Ghatta, Srinivas, Nimmagadda, Deepthi, Xu, Xiaoping, O'Rourke, Stephen T

“…The large-conductance, calcium-activated potassium channels (BK, also termed BK(Ca), Slo, or MaxiK) distributed in both excitable and non-excitable cells are…”
Get full text

Endothelin-1 regulates cardiac L-type calcium channels via NAD(P)H oxidase-derived superoxide by Zeng, Qinghua, Zhou, Qingwei, Yao, Fanrong, O'Rourke, Stephen T, Sun, Chengwen

“…It has been shown that reactive oxygen species (ROS) are involved in the intracellular signaling response to G-protein coupled receptor stimuli in vascular…”
Get more information

High salt-diet reduces SLC14A1 gene expression in the choroid plexus of Dahl salt sensitive rats by Guo, Lirong, Meng, Jie, Xuan, Chengluan, Ge, Jingyan, Sun, Wenzhu, O'Rourke, Stephen T., Sun, Chengwen

“…Elevated Na+ concentration ([Na+]) in the cerebrospinal fluid (CSF) contributes to the development of salt-sensitive hypertension. CSF is formed by the choroid…”
Get full text

20-Hydroxyeicosatetraenoic Acid Is a Key Mediator of Angiotensin II–induced Apoptosis in Cardiac Myocytes by Zhao, Huiying, Qi, Guohua, Han, Yong, Shen, Xin, Yao, Fanrong, Xuan, Chengluan, Gu, Yan, Qian, Steven Y, Zeng, Qinghua, OʼRourke, Stephen T, Sun, Chengwen

“…Cardiomyocyte apoptosis is involved in a variety of cardiac stresses, including ischemia-reperfusion injury, heart failure, and cardiomyopathy. Both…”
Get full text

MT2 receptors mediate the inhibitory effects of melatonin on nitric oxide-induced relaxation of porcine isolated coronary arteries by Tunstall, Radhika R, Shukla, Praveen, Grazul-Bilska, Anna, Sun, Chengwen, O'Rourke, Stephen T

“…Previous studies from our laboratory demonstrated that melatonin inhibits nitric oxide (NO)-induced relaxation in porcine coronary arteries. The present study…”
Get more information

Maternal nutrient restriction during pregnancy impairs an endothelium-derived hyperpolarizing factor-like pathway in sheep fetal coronary arteries by Shukla, Praveen, Ghatta, Srinivas, Dubey, Nidhi, Lemley, Caleb O, Johnson, Mary Lynn, Modgil, Amit, Vonnahme, Kimberly, Caton, Joel S, Reynolds, Lawrence P, Sun, Chengwen, O'Rourke, Stephen T

“…The mechanisms underlying developmental programming are poorly understood but may be associated with adaptations by the fetus in response to changes in the…”
Get more information

Pressor effect of apelin-13 in the rostral ventrolateral medulla: role of NAD(P)H oxidase-derived superoxide by Yao, Fanrong, Modgil, Amit, Zhang, Qi, Pingili, Ajeeth, Singh, Neha, O'Rourke, Stephen T, Sun, Chengwen

“…Microinjection of apelin-13 into the rostral ventrolateral medulla (RVLM) in the brainstem increases blood pressure in rats. In the present study, we tested…”
Get more information

Angiotensin II increases GABAB receptor expression in nucleus tractus solitarii of rats by Yao, Fanrong, Sumners, Colin, O'Rourke, Stephen T, Sun, Chengwen

“…Increasing evidence indicates that both the angiotensin II (ANG II) and gamma-aminobutyric acid (GABA) systems play a very important role in the regulation of…”
Get more information

Angiotensin-(1-7) attenuates the chronotropic response to angiotensin II via stimulation of PTEN in the spontaneously hypertensive rat neurons by Modgil, Amit, Zhang, Qi, Pingili, Ajeeth, Singh, Neha, Yao, Fanrong, Ge, Jingyan, Guo, Lirong, Xuan, Chengluan, O'Rourke, Stephen T, Sun, Chengwen

“…Several studies have focused on the beneficial effects of peripheral angiotensin-(1-7) [Ang-(1-7)] in the regulation of cardiovascular function, showing its…”
Get more information

Activation of APJ Receptors by CMF‐019, but not Apelin, Causes Endothelium‐Dependent Relaxation of Spontaneously Hypertensive Rat Coronary Arteries by Anto, Santo K., Sun, Chengwen, O'Rourke, Stephen T.

“…Hypertension is a major risk factor for coronary artery disease, but the pathophysiological mechanisms linking these diseases are not completely understood…”
Get full text

Corrigendum to “Intravenous administration of apeling-13 induces a depressor response by releasing an unidentified substance” [Biochem. Biophys. Res. Commun. 665 (2023) 202–207] by Yao, Fanrong, Niloy, Sayeman Islam, Shen, Yue, Zhang, Qi, O'Rourke, Stephen T., Sun, Chengwen

Get full text

Loss of IP3R-BKCa Coupling Is Involved in Vascular Remodeling in Spontaneously Hypertensive Rats by Niloy, Sayeman Islam, Shen, Yue, Guo, Lirong, O’Rourke, Stephen T., Sun, Chengwen

“…Mechanisms by which BKCa (large-conductance calcium-sensitive potassium) channels are involved in vascular remodeling in hypertension are not fully understood…”
Get full text