Search Results - "O'Rourke, Sinead"

Endogenous drivers of altered immune cell metabolism by Shanley, Lianne C, Fitzgerald, Hannah K, O’Rourke, Sinead A, Dunne, Aisling

“…Dysregulated metabolism has long been recognized as a feature of many metabolic disorders. However, recent studies demonstrating that metabolic reprogramming…”
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The Nrf2-HO-1 system and inflammaging by O'Rourke, Sinead A, Shanley, Lianne C, Dunne, Aisling

“…Nrf2 is a master transcriptional regulator of a number of genes involved in the adaptive response to oxidative stress. Among the genes upregulated by Nrf2,…”
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The Role of Macrophages in the Infarcted Myocardium: Orchestrators of ECM Remodeling by O'Rourke, Sinead A, Dunne, Aisling, Monaghan, Michael G

“…Myocardial infarction is the most common form of acute cardiac injury attributing to heart failure. While there have been significant advances in current…”
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Cholesterol crystals drive metabolic reprogramming and M1 macrophage polarisation in primary human macrophages by O'Rourke, Sinead A., Neto, Nuno G.B., Devilly, Eimear, Shanley, Lianne C., Fitzgerald, Hannah K., Monaghan, Michael G., Dunne, Aisling

“…Metabolic reprogramming of innate immune cells is emerging as a key player in the progression of a number of chronic diseases, including atherosclerosis, where…”
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Non-invasive classification of macrophage polarisation by 2P-FLIM and machine learning by Neto, Nuno GB, O'Rourke, Sinead A, Zhang, Mimi, Fitzgerald, Hannah K, Dunne, Aisling, Monaghan, Michael G

“…In this study, we utilise fluorescence lifetime imaging of NAD(P)H-based cellular autofluorescence as a non-invasive modality to classify two contrasting…”
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Staphylococcus aureus suppresses the pentose phosphate pathway in human neutrophils via the adenosine receptor A2aR to enhance intracellular survival by Vozza, Emilio G, Daly, Clíodhna M, O'Rourke, Sinead A, Fitzgerald, Hannah K, Dunne, Aisling, McLoughlin, Rachel M

“…is one of the leading causes of antimicrobial-resistant infections whose success as a pathogen is facilitated by its massive array of immune evasion tactics,…”
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Macrophage metabolic profile is altered by hydroxyapatite particle size by Shanley, Lianne C., Mahon, Olwyn R., O'Rourke, Sinead A., Neto, Nuno G.B., Monaghan, Michael G., Kelly, Daniel J., Dunne, Aisling

“…Since the recent observation that immune cells undergo metabolic reprogramming upon activation, there has been immense research in this area to not only…”
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Type 1 interferons promote Staphylococcus aureus nasal colonization by inducing phagocyte apoptosis by Vozza, Emilio G., Kelly, Alanna M., Daly, Clíodhna M., O’Rourke, Sinead A., Carlile, Simon R., Morris, Brenda, Dunne, Aisling, McLoughlin, Rachel M.

“…Staphylococcus aureus is an important human commensal which persistently colonizes up to 30% of the human population, predominantly within the nasal cavity…”
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The Trypanosoma brucei -Derived Ketoacids, Indole Pyruvate and Hydroxyphenylpyruvate, Induce HO-1 Expression and Suppress Inflammatory Responses in Human Dendritic Cells by Fitzgerald, Hannah K, O'Rourke, Sinead A, Desmond, Eva, Neto, Nuno G B, Monaghan, Michael G, Tosetto, Miriam, Doherty, Jayne, Ryan, Elizabeth J, Doherty, Glen A, Nolan, Derek P, Fletcher, Jean M, Dunne, Aisling

“…The extracellular parasite and causative agent of African sleeping sickness ( ) has evolved a number of strategies to avoid immune detection in the host. One…”
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The Notch-3 receptor: A molecular switch to tumorigenesis? by Inder, Shakeel, O'Rourke, Sinead, McDermott, Niamh, Manecksha, Rustom, Finn, Stephen, Lynch, Thomas, Marignol, Laure

“…•Deregulation of Notch-3 is associated with more aggressive, often chemo resistant malignancies.•Notch-3 acts as a molecular switch to a variety of biological…”
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Combining Next Generation Proteomics Platforms with Drug Sensitivity Resistance Testing Allows Identification of Physiologically Distinct Sub-Clones That Can Inform Therapeutic and Drug Development Strategies by Bazou, Despina, Majumder, Muntasir M, Tierney, Ciara, O'Rourke, Sinead, Anttila, Pekka, Silvennoinen, Raija Helena, Heckman, Caroline A, Dowling, Paul, O'Gorman, Peter

“…Introduction: A hallmark of Multiple Myeloma (MM) is the sequel development of drug resistant phenotypes, which may be present initially or emerge during the…”
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