Search Results - "O'Rourke, Martin"

Vasoactivity of AG014699, a Clinically Active Small Molecule Inhibitor of Poly(ADP-ribose) Polymerase: a Contributory Factor to Chemopotentiation In vivo? by ALI, Majid, TELFER, Brian A, CURTIN, Nicola J, WILLIAMS, Kaye J, MCCRUDDEN, Cian, O'ROURKE, Martin, THOMAS, Huw D, KAMJOO, Marzieh, KYLE, Suzanne, ROBSON, Tracy, SHAW, Chris, HIRST, David G

“…Purpose: Poly(ADP-ribose) polymerase (PARP) plays an important role in DNA repair, and PARP inhibitors can enhance the activity of DNA-damaging agents in vitro…”
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P3 SAR exploration of biphenyl carbamate based Legumain inhibitors by Higgins, Catherine, Bouazzaoui, Samira, Gaddale, Kishore, D’Costa, Zenobia, Templeman, Amy, O’Rourke, Martin, Young, Andrew, Scott, Christopher, Harrison, Tim, Mullan, Paul, Williams, Rich

“…This Letter describes the further development and SAR exploration of a novel series of Legumain inhibitors. Based upon a previously identified Legumain…”
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FKBPL and Peptide Derivatives: Novel Biological Agents that Inhibit Angiogenesis by a CD44-Dependent Mechanism by VALENTINE, Andrea, O'ROURKE, Martin, MCKEEN, Hayley, WAUGH, David J. J, ROBERTS, Jennifer, MCGREGOR, Joanne, COTTON, Graham, JAMES, Lain, HARRISON, Timothy, HIRST, David G, ROBSON, Tracy, YAKKUNDI, Anita, WORTHINGTON, Jenny, HOOKHAM, Michelle, BICKNELL, Roy, MCCARTHY, Helen O, MCCLELLAND, Keeva, MCCALLUM, Lynn, DYER, Hayder

“…Antiangiogenic therapies can be an important adjunct to the management of many malignancies. Here we investigated a novel protein, FKBPL, and peptide…”
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GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer by Liang, Jun, Zbieg, Jason R., Blake, Robert A., Chang, Jae H., Daly, Stephen, DiPasquale, Antonio G., Friedman, Lori S., Gelzleichter, Thomas, Gill, Matthew, Giltnane, Jennifer M., Goodacre, Simon, Guan, Jane, Hartman, Steven J., Ingalla, Ellen Rei, Kategaya, Lorn, Kiefer, James R., Kleinheinz, Tracy, Labadie, Sharada S., Lai, Tommy, Li, Jun, Liao, Jiangpeng, Liu, Zhiguo, Mody, Vidhi, McLean, Neville, Metcalfe, Ciara, Nannini, Michelle A., Oeh, Jason, O’Rourke, Martin G., Ortwine, Daniel F., Ran, Yingqing, Ray, Nicholas C., Roussel, Fabien, Sambrone, Amy, Sampath, Deepak, Schutt, Leah K., Vinogradova, Maia, Wai, John, Wang, Tao, Wertz, Ingrid E., White, Jonathan R., Yeap, Siew Kuen, Young, Amy, Zhang, Birong, Zheng, Xiaoping, Zhou, Wei, Zhong, Yu, Wang, Xiaojing

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Identification and functional analysis of a novel bradykinin inhibitory peptide in the venoms of New World Crotalinae pit vipers by James Graham, Robert Leslie, Graham, Ciaren, McClean, Stephen, Chen, Tianbao, O’Rourke, Martin, Hirst, David, Theakston, David, Shaw, Chris

“…A novel undecapeptide has been isolated and structurally characterized from the venoms of three species of New World pit vipers from the subfamily, Crotalinae…”
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FKBPL and its peptide derivatives inhibit endocrine therapy resistant cancer stem cells and breast cancer metastasis by downregulating DLL4 and Notch4 by McClements, Lana, Annett, Stephanie, Yakkundi, Anita, O'Rourke, Martin, Valentine, Andrea, Moustafa, Nermeen, Alqudah, Abdelrahim, Simões, Bruno M, Furlong, Fiona, Short, Amy, McIntosh, Stuart A, McCarthy, Helen O, Clarke, Robert B, Robson, Tracy

“…Optimising breast cancer treatment remains a challenge. Resistance to therapy is a major problem in both ER- and ER+ breast cancer. Tumour recurrence after…”
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Evaluation of the Antiangiogenic Potential of AQ4N by O'ROURKE, Martin, WARD, Claire, WORTHINGTON, Jenny, MCKENNA, Julie, VALENTINE, Andrea, ROBSON, Tracy, HIRST, David G, MCKEOWN, Stephanie R

“…Purpose: A number of cytotoxic chemotherapy agents tested at low concentrations show antiangiogenic properties with limited cytotoxicity, e.g.,…”
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Identification and development of a subtype-selective allosteric AKT inhibitor suitable for clinical development by Page, Natalie, Wappett, Mark, O’Dowd, Colin R., O’Rourke, Martin, Gavory, Gerald, Zhang, Lixin, Rountree, J. S. Shane, Jordan, Linda, Barker, Oliver, Gibson, Hayley, Boyd, Caroline, Feutren-Burton, Stephanie, McLean, Estelle, Trevitt, Graham, Harrison, Timothy

“…The serine/threonine protein kinase AKT plays a pivotal role within the PI3K pathway in regulating cellular proliferation and apoptotic cellular functions, and…”
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Vasoactivity of rucaparib, a PARP-1 inhibitor, is a complex process that involves myosin light chain kinase, P2 receptors, and PARP itself by McCrudden, Cian M, O'Rourke, Martin G, Cherry, Kim E, Yuen, Hiu-Fung, O'Rourke, Declan, Babur, Muhammad, Telfer, Brian A, Thomas, Huw D, Keane, Patrick, Nambirajan, Thiagarajan, Hagan, Chris, O'Sullivan, Joe M, Shaw, Chris, Williams, Kaye J, Curtin, Nicola J, Hirst, David G, Robson, Tracy

“…Therapeutic inhibition of poly(ADP-ribose) polymerase (PARP), as monotherapy or to supplement the potencies of other agents, is a promising strategy in cancer…”
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Bradykinin-related peptides, including a novel structural variant, (Val 1)-bradykinin, from the skin secretion of Guenther's frog, Hylarana guentheri and their molecular precursors by Zhou, Jianwu, Bjourson, Anthony J., Coulter, Daniel J.M., Chen, Tianbao, Shaw, Chris, O’Rourke, Martin, Hirst, David G., Zhang, Yany, Rao, Pingfan, McClean, Stephen

“…Multiple bradykinin-related peptides including a novel bradykinin structural variant, (Val 1)-bradykinin, have been identified from the defensive skin…”
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Bradykinins and their precursor cDNAs from the skin of the fire-bellied toad ( Bombina orientalis) by Chen, Tianbao, Orr, David F, Bjourson, Anthony J, McClean, Stephen, O’Rourke, Martin, Hirst, David G, Rao, Pingfan, Shaw, Chris

“…Bradykinin and (Thr 6)-bradykinin have been identified in the defensive skin secretion of the fire-bellied toad, Bombina orientalis. The homologous cDNAs for…”
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Abstract 1730: A translational platform using primary human immune cells in vitro, syngeneic and humanized models in vivo to support and advance immuno-oncology drug discovery by O'Rourke, Martin, Roman, Shilina, Salmon, Gary, Waddell, Ian, Schueler, Julia, Wood, Edgar

“…Abstract Charles River Laboratories (CRL) has established a powerful translational immuno-oncology platform with the capability of progressing biologics or…”
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Helokinestatin: A new bradykinin B 2 receptor antagonist decapeptide from lizard venom by Kwok, Hang Fai, Chen, Tianbao, O’Rourke, Martin, Ivanyi, Craig, Hirst, David, Shaw, Chris

“…Synthetic bradykinin antagonist peptides/peptoids have been powerful tools for delineating the roles of kinins in both normal physiology and in pathological…”
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The effect of nicotinamide on spontaneous and induced activity in smooth and skeletal muscle by Ruddock, Mark W, Burns, Deirdre M, Murphy, Lynne E, O'Rourke, Martin G, Hirst, David G

“…Background and purpose: Nicotinamide (NA) is currently undergoing clinical trials as a tumour radiosensitizer. The dose that can be administered is currently…”
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Helokinestatin : A new bradykinin B2 receptor antagonist decapeptide from lizard venom by HANG FAI KWOK, TIANBAO CHEN, O'ROURKE, Martin, IVANYI, Craig, HIRST, Dauid, SHAW, Chris

“…Synthetic bradykinin antagonist peptides/peptoids have been powerful tools for delineating the roles of kinins in both normal physiology and in pathological…”
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The complex array of bradykinin-related peptides (BRPs) in the peptidome of pickerel frog ( Rana palustris) skin secretion is the product of transcriptional economy by McCrudden, Cian Michael, Zhou, Mei, Chen, Tianbao, O’Rourke, Martin, Walker, Brian, Hirst, David, Shaw, Chris

“…Previous peptidomic analyses of the defensive skin secretion from the North American pickerel frog, Rana palustris, have established the presence of canonical…”
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FKBPL Regulates Estrogen Receptor Signaling and Determines Response to Endocrine Therapy by MCKEEN, Hayley D, BYRNE, Christopher, ROBSON, Tracy, JITHESH, Puthen V, DONLEY, Christopher, VALENTINE, Andrea, YAKKUNDI, Anita, O'ROURKE, Martin, SWANTON, Charles, MCCARTHY, Helen O, HIRST, David G

“…The HSP90 chaperone and immunophilin FKBPL is an estrogen-responsive gene that interacts with estogen receptor alpha (ERalpha) and regulates its levels. In…”
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A Novel FK506-Like Binding Protein Interacts with the Glucocorticoid Receptor and Regulates Steroid Receptor Signaling by McKeen, Hayley D, McAlpine, Kerry, Valentine, Andrea, Quinn, Derek J, McClelland, Keeva, Byrne, Christopher, O'Rourke, Martin, Young, Sheila, Scott, Christopher J, McCarthy, Helen O, Hirst, David G, Robson, Tracy

“…FKBP-like (FKBPL) protein is a novel immunophilin-like protein that plays a role in the cellular stress response. Its three tetratricopeptide repeat motifs are…”
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Abstract 3288: The anti-tumour efficacy of the novel peptide inhibitor of angiogenesis ALM-201 by O'Rourke, Martin, Valentine, Andrea, McLean, Estelle, Page, Natalie, Cotton, Graham, Robson, Tracy, Hirst, David, Harrison, Timothy, James, Iain

“…Abstract Neovascularization is critical to tumour growth and metastasis and this has led to the development of a number of marketed anti-angiogenic agents…”
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Pericytes influence endothelial cell growth characteristics : Role of plasminogen activator inhibitor type 1 (PAI-1) by MCILROY, Marie, O'ROURKE, Martin, MCKEOWN, Stephanie R, HIRST, David G, ROBSON, Tracy

“…Pericytes, located in close proximity to the underlying endothelium, form an integral component of the microvasculature. These cells are intimately involved in…”
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