Search Results - "O'Rourke, M A"

Multicenter Phase II Study to Evaluate a 28-Day Regimen of Oral Fluorouracil Plus Eniluracil in the Treatment of Patients With Previously Untreated Metastatic Colorectal Cancer by MANI, S, HOCHSTER, H, HOHNEKER, J, SCHILSKY, R. L, LOKICH, J, BECK, T, CHEVLEN, E. M, O'ROURKE, M. A, WEAVER, C. H, BELL, W. N, WHITE, R, MCGUIRT, C, LEVIN, J

“…To determine the efficacy of fluorouracil (5-FU) plus eniluracil when administered to patients with previously untreated metastatic colorectal cancer. In this…”
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Activated CD8 binding to class I protein mediated by the T-cell receptor results in signalling by O'Rourke, Anne M, Rogers, Joy, Mescher, Matthew F

“…The CD8 glycoprotein of T cells bind nonpolymorphic regions of class I major histocompatibility complex proteins on target cells and these interactions promote…”
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Signals for activation of CD8-dependent adhesion and costimulation in CTLs by O'Rourke, AM, Mescher, MF

“…Adhesion of CD8+ CTL to purified class I proteins has been shown to be regulated by the TCR: nonactivated CTL do not adhere to immobilized class I proteins…”
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Augmentation of mature CD4+ T cell responses to isolated antigenic class II proteins by fibronectin and intercellular adhesion molecule-1 by Brunmark, A, O'Rourke, AM

“…Mature CD4+ T cells can undergo stable adhesion to isolated antigenic MHC complexes, and upon TCR engagement exhibit up-regulated adhesion to the integrin…”
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Benefit of inhibiting SSAO in relapsing experimental autoimmune encephalomyelitis by O'Rourke, A M, Wang, E Y, Salter-Cid, L, Huang, L, Miller, A, Podar, E, Gao, H F, Jones, D S, Linnik, M D

“…We have developed several series of potent and selective small molecule inhibitors of SSAO (AOC3/VAP-1) that also block trafficking of leukocytes to sites of…”
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Contribution of lymphocyte function-associated-1/intercellular adhesion molecule-1 binding to the adhesion/signaling cascade of cytotoxic T lymphocyte activation by YBARRONDO, B, O'ROURKE, A. M, BRIAN, A. A, MESCHER, M. F

“…A rapid induction of adhesion to immobilized intercellular adhesion molecule (ICAM)-1 occurs when cytotoxic T lymphocytes (CTL) are stimulated with either…”
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T cell receptor-mediated signaling occurs in the absence of inositol phosphate production by O'Rourke, A M, Mescher, M F

“…Murine cytotoxic T lymphocytes (CTL) can lyse certain target cells in the presence or absence of extracellular Ca2+ (Ostergaard, H. L., Kane, K. P., Mescher,…”
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A Phase II Study of 9-Aminocamptothecin in Patients with Refractory Breast Cancer by Kraut, Eric H., Balcerzak, Stanley P., Young, Donn, O'Rourke, Mark A., Petrus, John J., Kuebler, J. Philip, Mayernik, David G.

“…Abstract We evaluated 9-aminocamptothecin (9-AC) in patients with metastatic or locally recurrent breast cancer who were no longer responsive to standard…”
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Cloning and sequencing of cDNA encoding mouse cytohesin-1 by O'Rourke, A M, Escuro, G, Feeney, A J

“…Cytohesin-1 has recently been identified as a potential regulatory molecule for LFA-1 in human T cells. Cytohesin-1 is a cytoplasmic protein containing a Sec7…”
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Activation of Polyphosphoinositide Hydrolysis in T Cells by H-2 Alloantigen But Not MLS Determinants by O'Rourke, Anne M., Mescher, Matthew F., Webb, Susan R.

“…Murine minor lymphocyte-stimulating (Mls) determinants are cell surface antigens that stimulate strong primary T cell responses; the responding T cells display…”
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Glucose, glutamine and ketone body utilisation by resting and concanavalin A activated rat splenic lymphocytes by O'Rourke, A M, Rider, C C

“…The utilisation of glucose, glutamine, acetoacetate and D-3-hydroxybutyrate were investigated over 72 h of incubation of rat splenic lymphocytes, with and…”
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Cytotoxic T-lymphocyte activation involves a cascade of signalling and adhesion events by O'Rourke, Anne M, Mescher, Matthew F

“…In addition to the antigen-specific T-cell receptor (TCR), T cells bear an array of 'accessory' molecules that can contribute to stable adhesion to the…”
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Vinorelbine (Navelbine)/carboplatin combination therapy: dose intensification with granulocyte colony-stimulating factor by Crawford, J, O'Rourke, M A

“…Treatment with platinum agents or the new vinca alkaloid vinorelbine (Navelbine; Burroughs Wellcome Co, Research Triangle Park, NC; Pierre Fabre Médicament,…”
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IgE receptor-mediated arachidonic acid release by rat basophilic leukemia (RBL-2H3) cells: possible role in activating degranulation by O'Rourke, A M, Mescher, M F, Apgar, J R

“…Aggregation of the IgE receptor on rat basophilic leukemia (RBL-2H3) cells triggers increased hydrolysis of polyphosphoinositides (PI), secretion of…”
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Cutting Edge: Trimolecular Interaction of TCR with MHC Class II and Bacterial Superantigen Shows a Similar Affinity to MHC:Peptide Ligands by Redpath, Stella, Alam, S. Munir, Lin, Christina M, O'Rourke, Anne M, Gascoigne, Nicholas R. J

“…Bacterial superantigens such as Staphylococcus aureus enterotoxin A (SEA) are very potent stimulators of T cells. They bind to the Vbeta region of the TCR and…”
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Nursing home placement and the demented patient by O'Rourke, M A

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Cytotoxic T‐lymphocyte interaction with fibronectin and vitronectin: activated adhesion and cosignalling by YBARRONDO, B., O’ROURKE, A. M., MCCARTHY, J. B., MESCHER, M. F.

“…Stimulation of cloned cytotoxic T lymphocytes (CTL) with anti‐T‐cell receptor (TCR) monoclonal antibody (mAb) in solution resulted in rapid and sustained…”
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Age Trends of Lung Cancer Stage at Diagnosis: Implications for Lung Cancer Screening in the Elderly by O'Rourke, Mark A, Feussner, John R, Feigl, Polly, Laszlo, John

“…Lung cancer increases in incidence with increasing age and is the leading cause of cancer death in the United States. While mass screening for lung cancer is…”
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Potentiation of opiate action in neuroblastoma N18TG2 cells by lipid incorporation by Law, P Y, Nicksic, T D, O'Rourke, M A, Koehler, J E, Herz, A, Loh, H H

“…The effect of cerebroside sulfate, phosphatidylserine, and other phospholipids on opiate receptor function in neuroblastoma N18TG2 cells was studied by…”
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The roles of CD8 in cytotoxic T lymphocyte function by O'Rourke, A M, Mescher, M F

“…The CD8 glycoprotein of cytotoxic T cells is both an adhesion protein and a cosignalling receptor. These functions are regulated by signals from the T-cell…”
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