Search Results - "O'Rourke, Donald"

Clinical investigation of CAR T cells for solid tumors: Lessons learned and future directions by Bagley, Stephen J., O’Rourke, Donald M.

“…Chimeric antigen receptor (CAR) T cells are a form of autologous immunotherapy that has changed the therapeutic landscape of hematologic malignancies. CAR T…”
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Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α by Wang, Qirui, He, Zhenqiang, Huang, Menggui, Liu, Tianrun, Wang, Yanling, Xu, Haineng, Duan, Hao, Ma, Peihong, Zhang, Lin, Zamvil, Scott S., Hidalgo, Juan, Zhang, Zhenfeng, O’Rourke, Donald M., Dahmane, Nadia, Brem, Steven, Mou, Yonggao, Gong, Yanqing, Fan, Yi

“…Spatiotemporal regulation of tumor immunity remains largely unexplored. Here we identify a vascular niche that controls alternative macrophage activation in…”
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PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma by Liu, Tianrun, Ma, Wenjuan, Xu, Haineng, Huang, Menggui, Zhang, Duo, He, Zhenqiang, Zhang, Lin, Brem, Steven, O’Rourke, Donald M., Gong, Yanqing, Mou, Yonggao, Zhang, Zhenfeng, Fan, Yi

“…Angiogenesis is a hallmark of cancer. However, most malignant solid tumors exhibit robust resistance to current anti-angiogenic therapies that primarily target…”
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Imaging Surrogates of Infiltration Obtained Via Multiparametric Imaging Pattern Analysis Predict Subsequent Location of Recurrence of Glioblastoma by Akbari, Hamed, Macyszyn, Luke, Da, Xiao, Bilello, Michel, Wolf, Ronald L., Martinez-Lage, Maria, Biros, George, Alonso-Basanta, Michelle, O'Rourke, Donald M., Davatzikos, Christos

“…Abstract BACKGROUND: Glioblastoma is an aggressive and highly infiltrative brain cancer. Standard surgical resection is guided by enhancement on postcontrast…”
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CAR T-cell therapy for glioblastoma: recent clinical advances and future challenges by Bagley, Stephen J, Desai, Arati S, Linette, Gerald P, June, Carl H, O'Rourke, Donald M

“…In patients with certain hematologic malignancies, the use of autologous T cells genetically modified to express chimeric antigen receptors (CARs) has led to…”
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Glioblastoma: The Current State of Biology and Therapeutic Strategies by Binder, Zev A, O'Rourke, Donald M

“…Over the past two decades, there have been advances in surgical technologies and chemoradiation strategies for glioblastoma, yet durable remissions are rarely…”
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A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity by Jacob, Fadi, Salinas, Ryan D., Zhang, Daniel Y., Nguyen, Phuong T.T., Schnoll, Jordan G., Wong, Samuel Zheng Hao, Thokala, Radhika, Sheikh, Saad, Saxena, Deeksha, Prokop, Stefan, Liu, Di-ao, Qian, Xuyu, Petrov, Dmitriy, Lucas, Timothy, Chen, H. Isaac, Dorsey, Jay F., Christian, Kimberly M., Binder, Zev A., Nasrallah, MacLean, Brem, Steven, O’Rourke, Donald M., Ming, Guo-li, Song, Hongjun

“…Glioblastomas exhibit vast inter- and intra-tumoral heterogeneity, complicating the development of effective therapeutic strategies. Current in vitro models…”
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A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma by O'Rourke, Donald M, Nasrallah, MacLean P, Desai, Arati, Melenhorst, Jan J, Mansfield, Keith, Morrissette, Jennifer J D, Martinez-Lage, Maria, Brem, Steven, Maloney, Eileen, Shen, Angela, Isaacs, Randi, Mohan, Suyash, Plesa, Gabriela, Lacey, Simon F, Navenot, Jean-Marc, Zheng, Zhaohui, Levine, Bruce L, Okada, Hideho, June, Carl H, Brogdon, Jennifer L, Maus, Marcela V

“…We conducted a first-in-human study of intravenous delivery of a single dose of autologous T cells redirected to the epidermal growth factor receptor variant…”
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Radiomic MRI signature reveals three distinct subtypes of glioblastoma with different clinical and molecular characteristics, offering prognostic value beyond IDH1 by Rathore, Saima, Akbari, Hamed, Rozycki, Martin, Abdullah, Kalil G., Nasrallah, MacLean P., Binder, Zev A., Davuluri, Ramana V., Lustig, Robert A., Dahmane, Nadia, Bilello, Michel, O’Rourke, Donald M., Davatzikos, Christos

“…The remarkable heterogeneity of glioblastoma, across patients and over time, is one of the main challenges in precision diagnostics and treatment planning…”
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Intrathecal bivalent CAR T cells targeting EGFR and IL13Rα2 in recurrent glioblastoma: phase 1 trial interim results by Bagley, Stephen J., Logun, Meghan, Fraietta, Joseph A., Wang, Xin, Desai, Arati S., Bagley, Linda J., Nabavizadeh, Ali, Jarocha, Danuta, Martins, Rene, Maloney, Eileen, Lledo, Lester, Stein, Carly, Marshall, Amy, Leskowitz, Rachel, Jadlowsky, Julie K., Christensen, Shannon, Oner, Bike Su, Plesa, Gabriela, Brennan, Andrea, Gonzalez, Vanessa, Chen, Fang, Sun, Yusha, Gladney, Whitney, Barrett, David, Nasrallah, MacLean P., Hwang, Wei-Ting, Ming, Guo-Li, Song, Hongjun, Siegel, Donald L., June, Carl H., Hexner, Elizabeth O., Binder, Zev A., O’Rourke, Donald M.

“…Recurrent glioblastoma (rGBM) remains a major unmet medical need, with a median overall survival of less than 1 year. Here we report the first six patients…”
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IDH mutation impairs histone demethylation and results in a block to cell differentiation by Lu, Chao, Ward, Patrick S., Kapoor, Gurpreet S., Rohle, Dan, Turcan, Sevin, Abdel-Wahab, Omar, Edwards, Christopher R., Khanin, Raya, Figueroa, Maria E., Melnick, Ari, Wellen, Kathryn E., O’Rourke, Donald M., Berger, Shelley L., Chan, Timothy A., Levine, Ross L., Mellinghoff, Ingo K., Thompson, Craig B.

“…Cancer-associated IDH mutants that produce 2-hydroxyglutarate are shown to prevent the histone demethylation that is required for lineage-specific progenitor…”
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Circulating Glioma Cells Exhibit Stem Cell-like Properties by Liu, Tianrun, Xu, Haineng, Huang, Menggui, Ma, Wenjuan, Saxena, Deeksha, Lustig, Robert A, Alonso-Basanta, Michelle, Zhang, Zhenfeng, O'Rourke, Donald M, Zhang, Lin, Gong, Yanqing, Kao, Gary D, Dorsey, Jay F, Fan, Yi

“…: Circulating tumor cells (CTC) are known to be present in the blood of patients with glioblastoma (GBM). Here we report that GBM-derived CTC possess a cancer…”
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A Randomized Double-Blind Placebo-Controlled Phase II Trial of Dendritic Cell Vaccine ICT-107 in Newly Diagnosed Patients with Glioblastoma by Wen, Patrick Y, Reardon, David A, Armstrong, Terri S, Phuphanich, Surasak, Aiken, Robert D, Landolfi, Joseph C, Curry, William T, Zhu, Jay-Jiguang, Glantz, Michael, Peereboom, David M, Markert, James M, LaRocca, Renato, O'Rourke, Donald M, Fink, Karen, Kim, Lyndon, Gruber, Michael, Lesser, Glenn J, Pan, Edward, Kesari, Santosh, Muzikansky, Alona, Pinilla, Clemencia, Santos, Radleigh G, Yu, John S

“…To evaluate the results of the randomized, double-blind, placebo-controlled phase II clinical trial of ICT-107 in patients with newly diagnosed glioblastoma…”
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Epidermal Growth Factor Receptor Extracellular Domain Mutations in Glioblastoma Present Opportunities for Clinical Imaging and Therapeutic Development by Binder, Zev A., Thorne, Amy Haseley, Bakas, Spyridon, Wileyto, E. Paul, Bilello, Michel, Akbari, Hamed, Rathore, Saima, Ha, Sung Min, Zhang, Logan, Ferguson, Cole J., Dahiya, Sonika, Bi, Wenya Linda, Reardon, David A., Idbaih, Ahmed, Felsberg, Joerg, Hentschel, Bettina, Weller, Michael, Bagley, Stephen J., Morrissette, Jennifer J.D., Nasrallah, MacLean P., Ma, Jianhui, Zanca, Ciro, Scott, Andrew M., Orellana, Laura, Davatzikos, Christos, Furnari, Frank B., O'Rourke, Donald M.

“…We explored the clinical and pathological impact of epidermal growth factor receptor (EGFR) extracellular domain missense mutations. Retrospective assessment…”
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Histopathology‐validated machine learning radiographic biomarker for noninvasive discrimination between true progression and pseudo‐progression in glioblastoma by Akbari, Hamed, Rathore, Saima, Bakas, Spyridon, Nasrallah, MacLean P., Shukla, Gaurav, Mamourian, Elizabeth, Rozycki, Martin, Bagley, Stephen J., Rudie, Jeffrey D., Flanders, Adam E., Dicker, Adam P., Desai, Arati S., O’Rourke, Donald M., Brem, Steven, Lustig, Robert, Mohan, Suyash, Wolf, Ronald L., Bilello, Michel, Martinez‐Lage, Maria, Davatzikos, Christos

“…Background Imaging of glioblastoma patients after maximal safe resection and chemoradiation commonly demonstrates new enhancements that raise concerns about…”
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In Vivo Detection of EGFRvIII in Glioblastoma via Perfusion Magnetic Resonance Imaging Signature Consistent with Deep Peritumoral Infiltration: The φ -Index by Bakas, Spyridon, Akbari, Hamed, Pisapia, Jared, Martinez-Lage, Maria, Rozycki, Martin, Rathore, Saima, Dahmane, Nadia, O'Rourke, Donald M, Davatzikos, Christos

“…The epidermal growth factor receptor variant III ( ) mutation has been considered a driver mutation and therapeutic target in glioblastoma, the most common and…”
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Immune landscapes associated with different glioblastoma molecular subtypes by Martinez-Lage, Maria, Lynch, Timothy M, Bi, Yingtao, Cocito, Carolina, Way, Gregory P, Pal, Sharmistha, Haller, Josephine, Yan, Rachel E, Ziober, Amy, Nguyen, Aivi, Kandpal, Manoj, O'Rourke, Donald M, Greenfield, Jeffrey P, Greene, Casey S, Davuluri, Ramana V, Dahmane, Nadia

“…Recent work has highlighted the tumor microenvironment as a central player in cancer. In particular, interactions between tumor and immune cells may help drive…”
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MRI-Based Radiomics Combined with Deep Learning for Distinguishing IDH-Mutant WHO Grade 4 Astrocytomas from IDH-Wild-Type Glioblastomas by Hosseini, Seyyed Ali, Hosseini, Elahe, Hajianfar, Ghasem, Shiri, Isaac, Servaes, Stijn, Rosa-Neto, Pedro, Godoy, Laiz, Nasrallah, MacLean P, O'Rourke, Donald M, Mohan, Suyash, Chawla, Sanjeev

“…This study aimed to investigate the potential of quantitative radiomic data extracted from conventional MR images in discriminating IDH-mutant grade 4…”
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Clinical measures, radiomics, and genomics offer synergistic value in AI-based prediction of overall survival in patients with glioblastoma by Fathi Kazerooni, Anahita, Saxena, Sanjay, Toorens, Erik, Tu, Danni, Bashyam, Vishnu, Akbari, Hamed, Mamourian, Elizabeth, Sako, Chiharu, Koumenis, Costas, Verginadis, Ioannis, Verma, Ragini, Shinohara, Russell T., Desai, Arati S., Lustig, Robert A., Brem, Steven, Mohan, Suyash, Bagley, Stephen J., Ganguly, Tapan, O’Rourke, Donald M., Bakas, Spyridon, Nasrallah, MacLean P., Davatzikos, Christos

“…Multi-omic data, i.e., clinical measures, radiomic, and genetic data, capture multi-faceted tumor characteristics, contributing to a comprehensive patient risk…”
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EGFR, the Lazarus target for precision oncology in glioblastoma by Lin, Benjamin, Ziebro, Julia, Smithberger, Erin, Skinner, Kasey R, Zhao, Eva, Cloughesy, Timothy F, Binder, Zev A, O'Rourke, Donald M, Nathanson, David A, Furnari, Frank B, Miller, C Ryan

“…The Lazarus effect is a rare condition that happens when someone seemingly dead shows signs of life. The epidermal growth factor receptor (EGFR) represents a…”
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