Search Results - "O'Rourke, B"

Excitation-contraction coupling and mitochondrial energetics by Maack, Christoph, O'Rourke, Brian

“…Cardiac excitation-contraction (EC) coupling consumes vast amounts of cellular energy, most of which is produced in mitochondria by oxidative phosphorylation…”
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Analysis of formalin-fixed, paraffin-embedded (FFPE) tissue via proteomic techniques and misconceptions of antigen retrieval by O'Rourke, Matthew B, Padula, Matthew P

“…Since emerging in the late 19(th) century, formaldehyde fixation has become a standard method for preservation of tissues from clinical samples. The advantage…”
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Cooling positronium to ultralow velocities with a chirped laser pulse train by Shu, K., Tajima, Y., Uozumi, R., Miyamoto, N., Shiraishi, S., Kobayashi, T., Ishida, A., Yamada, K., Gladen, R. W., Namba, T., Asai, S., Wada, K., Mochizuki, I., Hyodo, T., Ito, K., Michishio, K., O’Rourke, B. E., Oshima, N., Yoshioka, K.

“…When laser radiation is skilfully applied, atoms and molecules can be cooled 1 – 3 , allowing the precise measurements and control of quantum systems. This is…”
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From adaptive licensing to adaptive pathways: Delivering a flexible life-span approach to bring new drugs to patients by Eichler, H-G, Baird, LG, Barker, R, Bloechl-Daum, B, Børlum-Kristensen, F, Brown, J, Chua, R, Del Signore, S, Dugan, U, Ferguson, J, Garner, S, Goettsch, W, Haigh, J, Honig, P, Hoos, A, Huckle, P, Kondo, T, Le Cam, Y, Leufkens, H, Lim, R, Longson, C, Lumpkin, M, Maraganore, J, O'Rourke, B, Oye, K, Pezalla, E, Pignatti, F, Raine, J, Rasi, G, Salmonson, T, Samaha, D, Schneeweiss, S, Siviero, PD, Skinner, M, Teagarden, JR, Tominaga, T, Trusheim, MR, Tunis, S, Unger, TF, Vamvakas, S, Hirsch, G

“…The concept of adaptive licensing (AL) has met with considerable interest. Yet some remain skeptical about its feasibility. Others argue that the focus and…”
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Dr Peter John Healy: 1940-2019 by Walker, K, O'Rourke, B, Dennis, J

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An Atypical Parvovirus Drives Chronic Tubulointerstitial Nephropathy and Kidney Fibrosis by Roediger, Ben, Lee, Quintin, Tikoo, Shweta, Cobbin, Joanna C.A., Henderson, James M., Jormakka, Mika, O’Rourke, Matthew B., Padula, Matthew P., Pinello, Natalia, Henry, Marisa, Wynne, Maria, Santagostino, Sara F., Brayton, Cory F., Rasmussen, Lorna, Lisowski, Leszek, Tay, Szun S., Harris, David C., Bertram, John F., Dowling, John P., Bertolino, Patrick, Lai, Jack H., Wu, Wengen, Bachovchin, William W., Wong, Justin J.-L., Gorrell, Mark D., Shaban, Babak, Holmes, Edward C., Jolly, Christopher J., Monette, Sébastien, Weninger, Wolfgang

“…The occurrence of a spontaneous nephropathy with intranuclear inclusions in laboratory mice has puzzled pathologists for over 4 decades, because its etiology…”
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Murine and related chapparvoviruses are nephro-tropic and produce novel accessory proteins in infected kidneys by Lee, Quintin, Padula, Matthew P, Pinello, Natalia, Williams, Simon H, O'Rourke, Matthew B, Fumagalli, Marcilio Jorge, Orkin, Joseph D, Song, Renhua, Shaban, Babak, Brenner, Ori, Pimanda, John E, Weninger, Wolfgang, Souza, William Marciel de, Melin, Amanda D, Wong, Justin J-L, Crim, Marcus J, Monette, Sébastien, Roediger, Ben, Jolly, Christopher J

“…Mouse kidney parvovirus (MKPV) is a member of the provisional genus Chapparvovirus that causes renal disease in immune-compromised mice, with a disease course…”
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Quantitative Proteomic Profiling of Small Molecule Treated Mesenchymal Stem Cells Using Chemical Probes by Santos, Jerran, Dolai, Sibasish, O'Rourke, Matthew B, Liu, Fei, Padula, Matthew P, Molloy, Mark P, Milthorpe, Bruce K

“…The differentiation of human adipose derived stem cells toward a neural phenotype by small molecules has been a vogue topic in the last decade. The…”
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Adaptive Licensing: Taking the Next Step in the Evolution of Drug Approval by Eichler, H‐G, Oye, K, Baird, L G, Abadie, E, Brown, J, Drum, C L, Ferguson, J, Garner, S, Honig, P, Hukkelhoven, M, Lim, J C W, Lim, R, Lumpkin, M M, Neil, G, O'Rourke, B, Pezalla, E, Shoda, D, Seyfert‐Margolis, V, Sigal, E V, Sobotka, J, Tan, D, Unger, T F, Hirsch, G

“…Traditional drug licensing approaches are based on binary decisions. At the moment of licensing, an experimental therapy is presumptively transformed into a…”
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Molecular evidence to suggest pigeon‐type Chlamydia psittaci in association with an equine foal loss by Jelocnik, M., Jenkins, C., O'Rourke, B., Barnwell, J., Polkinghorne, A.

“…Summary Chlamydia psittaci is an important avian pathogen with spillover from infected wild and domesticated birds also posing a risk to human health. We…”
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Development and validation of the patient centeredness index for primary care by Rose, Gail L., Bonnell, Levi N., O'Rourke‐Lavoie, Jennifer B., Eeghen, Constance, Reynolds, Paula, Pomeroy, Doug, Clifton, Jessica, Scholle, Sarah Hudson, Natkin, Lisa W., Callas, Peter, Hitt, Juvena R., Crocker, Abigail M., Littenberg, Benjamin

“…Aims and Objectives To describe the development of the Patient Centeredness Index (PCI), evaluate its psychometric characteristics and evaluate the…”
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Matrix phase fractionation: Investigating the compromise between dynamic range of analyte extraction and spatial resolution in mass spectrometry imaging by O’Rourke, Matthew B., Viengkhou, Barney, Smith, Caine C., Sonderegger, Lorenz, Padula, Matthew P., Sutherland, Greg T., Hofer, Markus J., Crossett, Ben

“…Rationale Matrix‐assisted laser desorption ionisation with mass spectrometry imaging (MSI) has seen rapid development in recent years and as such is becoming…”
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Suspected hereditary cervicothoracic vertebral subluxation with cervical myopathy in Poll Merino sheep by Cronin, N, Loukopoulos, P, Brown, D, O'Rourke, BA, Morrice, G, Windsor, PA

“…Background Cervicothoracic vertebral subluxation in sheep presents as a postural and locomotor disorder, and has been described in several breeds in Australia…”
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An ABCA12 missense variant in a Shorthorn calf with ichthyosis fetalis by Woolley, S. A., Eager, K. L. M., Häfliger, I. M., Bauer, A., Drögemüller, C., Leeb, T., O'Rourke, B. A., Tammen, I.

“…Summary Two clinical forms of ichthyosis in cattle have been reported, ichthyosis fetalis and congenital ichthyosis. Ichthyosis poses animal welfare and…”
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Equine chlamydiosis—An emerging infectious disease requiring a one health surveillance approach by Taylor, K. A., Durrheim, D., Heller, J., O'Rourke, B., Hope, K., Merritt, T., Freeman, P., Chicken, C., Carrick, J., Branley, J., Massey, P.

“…Summary Psittacosis is a rare but potentially fatal zoonosis caused by Chlamydia psittaci, an organism that is typically associated with bird contact. However…”
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Optimal Preparation of Formalin Fixed Samples for Peptide Based Matrix Assisted Laser Desorption/Ionization Mass Spectrometry Imaging Workflows by O'Rourke, Matthew B, Padula, Matthew P, Smith, Caine, Youssef, Priscilla, Cordwell, Stuart, Witting, Paul, Sutherland, Greg, Crossett, Ben

“…The use of matrix-assisted laser desorption/ionization, mass spectrometry imaging (MALDI MSI) has rapidly expanded, since this technique analyzes a host of…”
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Higher Mass Accuracy MALDI-TOF/TOF Lipid Imaging of Human Brain Tissue in Alzheimer's Disease by O'Rourke, Matthew B, Smith, Caine C, De La Monte, Suzanne M, Sutherland, Greg T, Padula, Matthew P

“…Matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI-IMS) is a well-established technique for elucidating the location and relative…”
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Two-Photon Excitation of Quantum-Dot-Based Fluorescence Resonance Energy Transfer and Its Applications by Clapp, A. R., Pons, T., Medintz, I. L., Delehanty, J. B., Melinger, J. S., Tiefenbrunn, T., Dawson, P. E., Fisher, B. R., O'Rourke, B., Mattoussi, H.

“…Nonradiative fluorescence resonance energy transfer (FRET) between a luminescent quantum dot (QD) donor and a proximal dye brought in close proximity of the QD…”
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Effects of 4′-chlorodiazepam on cellular excitation–contraction coupling and ischaemia–reperfusion injury in rabbit heart by Brown, David A., Aon, Miguel A., Akar, Fadi G., Liu, Ting, Sorarrain, Nicolas, O’Rourke, Brian

“…Aims Recent evidence indicates that the activity of energy-dissipating ion channels in the mitochondria can influence the susceptibility of the heart to…”
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Inferring the recent ancestry of myostatin alleles affecting muscle mass in cattle by O'Rourke, B. A., Greenwood, P. L., Arthur, P. F., Goddard, M. E.

“…Summary Double muscling is an inherited condition in cattle characterised by large increases in muscle mass. Mutations in the myostatin (MSTN) gene,…”
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