Search Results - "O'Riordan, Mary X"

Mitochondria-Derived Vesicles Deliver Antimicrobial Reactive Oxygen Species to Control Phagosome-Localized Staphylococcus aureus by Abuaita, Basel H., Schultz, Tracey L., O’Riordan, Mary X.

“…Pathogenic bacteria taken up into the macrophage phagosome are the target of many anti-microbial mechanisms. Although mitochondria-derived antimicrobial…”
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Astrovirus replication in human intestinal enteroids reveals multi-cellular tropism and an intricate host innate immune landscape by Kolawole, Abimbola O, Mirabelli, Carmen, Hill, David R, Svoboda, Sophia A, Janowski, Andrew B, Passalacqua, Karla D, Rodriguez, Benancio N, Dame, Michael K, Freiden, Pamela, Berger, Ryan P, Vu, Diem-Lan, Hosmillo, Myra, O'Riordan, Mary X D, Schultz-Cherry, Stacey, Guix, Susana, Spence, Jason R, Wang, David, Wobus, Christiane E

“…Human astroviruses (HAstV) are understudied positive-strand RNA viruses that cause gastroenteritis mostly in children and the elderly. Three clades of…”
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Comparative transcriptional profiling of the early host response to infection by typhoidal and non-typhoidal Salmonella serovars in human intestinal organoids by Abuaita, Basel H, Lawrence, Anna-Lisa E, Berger, Ryan P, Hill, David R, Huang, Sha, Yadagiri, Veda K, Bons, Brooke, Fields, Courtney, Wobus, Christiane E, Spence, Jason R, Young, Vincent B, O'Riordan, Mary X

“…Salmonella enterica represents over 2500 serovars associated with a wide-ranging spectrum of disease; from self-limiting gastroenteritis to invasive infections…”
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Regulation of bacterial pathogenesis by intestinal short-chain Fatty acids by Sun, Yvonne, O'Riordan, Mary X D

“…The human gut microbiota is inextricably linked to health and disease. One important function of the commensal organisms living in the intestine is to provide…”
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Human neutrophil IL1β directs intestinal epithelial cell extrusion during Salmonella infection by Lawrence, Anna-Lisa E, Berger, Ryan P, Hill, David R, Huang, Sha, Yadagiri, Veda K, Bons, Brooke, Fields, Courtney, Sule, Gautam J, Knight, Jason S, Wobus, Christiane E, Spence, Jason R, Young, Vincent B, O'Riordan, Mary X, Abuaita, Basel H

“…Infection of the human gut by Salmonella enterica Typhimurium (STM) results in a localized inflammatory disease that is not mimicked in murine infections. To…”
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MRSA in Stealth Mode Evades Antibody Recognition by Passalacqua, Karla D., O’Riordan, Mary X.

“…In Nature, Gerlach et al. (Nature 2018;563:705–709) report that methicillin-resistant Staphylococcus aureus camouflages its surface by displaying a ‘stealth’…”
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The IRE1α Stress Signaling Axis Is a Key Regulator of Neutrophil Antimicrobial Effector Function by Abuaita, Basel H, Sule, Gautam J, Schultz, Tracey L, Gao, Fushan, Knight, Jason S, O'Riordan, Mary X

“…Activation of the endoplasmic reticulum stress sensor, IRE1α, is required for effective immune responses against bacterial infection and is associated with…”
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Glycolysis Is an Intrinsic Factor for Optimal Replication of a Norovirus by Passalacqua, Karla D, Lu, Jia, Goodfellow, Ian, Kolawole, Abimbola O, Arche, Jacob R, Maddox, Robert J, Carnahan, Kelly E, O'Riordan, Mary X D, Wobus, Christiane E

“…The metabolic pathways of central carbon metabolism, glycolysis and oxidative phosphorylation (OXPHOS), are important host factors that determine the outcome…”
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Endoplasmic reticulum stress sensor IRE1α propels neutrophil hyperactivity in lupus by Sule, Gautam, Abuaita, Basel H, Steffes, Paul A, Fernandes, Andrew T, Estes, Shanea K, Dobry, Craig, Pandian, Deepika, Gudjonsson, Johann E, Kahlenberg, J Michelle, O'Riordan, Mary X, Knight, Jason S

“…Neutrophils amplify inflammation in lupus through the release of neutrophil extracellular traps (NETs). The endoplasmic reticulum stress sensor…”
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The IRE1α-XBP1 Signaling Axis Promotes Glycolytic Reprogramming in Response to Inflammatory Stimuli by English, Bevin C, Savage, Hannah P, Mahan, Scott P, Diaz-Ochoa, Vladimir E, Young, Briana M, Abuaita, Basel H, Sule, Gautam, Knight, Jason S, O'Riordan, Mary X, Bäumler, Andreas J, Tsolis, Renée M

“…Immune cells must be able to adjust their metabolic programs to effectively carry out their effector functions. Here, we show that the endoplasmic reticulum…”
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Invasion of the Brain by Listeria monocytogenes Is Mediated by InlF and Host Cell Vimentin by Ghosh, Pallab, Halvorsen, Elizabeth M, Ammendolia, Dustin A, Mor-Vaknin, Nirit, O'Riordan, Mary X D, Brumell, John H, Markovitz, David M, Higgins, Darren E

“…is a facultative intracellular bacterial pathogen that is frequently associated with food-borne infection. Of particular concern is the ability of to breach…”
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Salmonella enterica Serovar Typhimurium SPI-1 and SPI-2 Shape the Global Transcriptional Landscape in a Human Intestinal Organoid Model System by Lawrence, Anna-Lisa E, Abuaita, Basel H, Berger, Ryan P, Hill, David R, Huang, Sha, Yadagiri, Veda K, Bons, Brooke, Fields, Courtney, Wobus, Christiane E, Spence, Jason R, Young, Vincent B, O'Riordan, Mary X

“…The intestinal epithelium is a primary interface for engagement of the host response by foodborne pathogens, like Typhimurium. While the interaction of…”
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Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage by Bronner, Denise N., Abuaita, Basel H., Chen, Xiaoyun, Fitzgerald, Katherine A., Nuñez, Gabriel, He, Yongqun, Yin, Xiao-Ming, O’Riordan, Mary X.D.

“…Endoplasmic reticulum (ER) stress is observed in many human diseases, often associated with inflammation. ER stress can trigger inflammation through…”
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Fatty Acids Regulate Stress Resistance and Virulence Factor Production for Listeria monocytogenes by Sun, Yvonne, Wilkinson, Brian J, Standiford, Theodore J, Akinbi, Henry T, O'Riordan, Mary X. D

“…Fatty acids (FAs) are the major structural component of cellular membranes, which provide a physical and chemical barrier that insulates intracellular…”
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Type I interferon governs immunometabolic checkpoints that coordinate inflammation during Staphylococcal infection by Reynolds, Mack B., Klein, Benjamin, McFadden, Michael J., Judge, Norah K., Navarrete, Hannah E., Michmerhuizen, Britton C, Awad, Dominik, Schultz, Tracey L., Harms, Paul W., Zhang, Li, O’Meara, Teresa R., Sexton, Jonathan Z., Lyssiotis, Costas A., Kahlenberg, J. Michelle, O’Riordan, Mary X.

“…Macrophage metabolic plasticity is central to inflammatory programming, yet mechanisms of coordinating metabolic and inflammatory programs during infection are…”
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The Mitochondrial Fission Regulator DRP1 Controls Post-Transcriptional Regulation of TNF-α by Gao, Fushan, Reynolds, Mack B, Passalacqua, Karla D, Sexton, Jonathan Z, Abuaita, Basel H, O'Riordan, Mary X D

“…The mitochondrial network plays a critical role in the regulation of innate immune signaling and subsequent production of proinflammatory cytokines such as…”
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The Endoplasmic Reticulum Stress Sensor Inositol-Requiring Enzyme 1α Augments Bacterial Killing through Sustained Oxidant Production by Abuaita, Basel H, Burkholder, Kristin M, Boles, Blaise R, O'Riordan, Mary X

“…Bacterial infection can trigger cellular stress programs, such as the unfolded protein response (UPR), which occurs when misfolded proteins accumulate within…”
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Innate recognition of intracellular bacteria by Delbridge, Laura M, O’Riordan, Mary XD

“…The molecular repertoire for innate recognition of bacterial pathogens has expanded rapidly in the past decade. These immunosensors include Toll-like receptors…”
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ER-associated degradation adapter Sel1L is required for CD8+ T cell function and memory formation following acute viral infection by Correa-Medero, Luis O., Jankowski, Shayna E., Hong, Hanna S., Armas, Nicholas D., Vijendra, Aditi I., Reynolds, Mack B., Fogo, Garrett M., Awad, Dominik, Dils, Alexander T., Inoki, Kantaro A., Williams, Reid G., Ye, Annabelle M., Svezhova, Nadezhda, Gomez-Rivera, Francisco, Collins, Kathleen L., O’Riordan, Mary X., Sanderson, Thomas H., Lyssiotis, Costas A., Carty, Shannon A.

“…The maintenance of antigen-specific CD8+ T cells underlies the efficacy of vaccines and immunotherapies. Pathways contributing to CD8+ T cell loss are not…”
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Branched-Chain Fatty Acids Promote Listeria monocytogenes Intracellular Infection and Virulence by Sun, Yvonne, O'Riordan, Mary X.D

“…Anteiso-branched-chain fatty acids (BCFA) represent the dominant group of membrane fatty acids and have been established as crucial determinants in resistance…”
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