Search Results - "O'Riordan, Kenneth J"

The gut microbiome in neurological disorders by Cryan, John F, O'Riordan, Kenneth J, Sandhu, Kiran, Peterson, Veronica, Dinan, Timothy G

“…Research into the role of the gut microbiome in modulating brain function has rapidly increased over the past 10 years, albeit chiefly in animal models…”
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Microbiota-Gut-Brain Axis: New Therapeutic Opportunities by Long-Smith, Caitríona, O'Riordan, Kenneth J, Clarke, Gerard, Stanton, Catherine, Dinan, Timothy G, Cryan, John F

“…The traditional fields of pharmacology and toxicology are beginning to consider the substantial impact our gut microbiota has on host physiology. The…”
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The Microbiota-Gut-Brain Axis by Cryan, John F, O'Riordan, Kenneth J, Cowan, Caitlin S M, Sandhu, Kiran V, Bastiaanssen, Thomaz F S, Boehme, Marcus, Codagnone, Martin G, Cussotto, Sofia, Fulling, Christine, Golubeva, Anna V, Guzzetta, Katherine E, Jaggar, Minal, Long-Smith, Caitriona M, Lyte, Joshua M, Martin, Jason A, Molinero-Perez, Alicia, Moloney, Gerard, Morelli, Emanuela, Morillas, Enrique, O'Connor, Rory, Cruz-Pereira, Joana S, Peterson, Veronica L, Rea, Kieran, Ritz, Nathaniel L, Sherwin, Eoin, Spichak, Simon, Teichman, Emily M, van de Wouw, Marcel, Ventura-Silva, Ana Paula, Wallace-Fitzsimons, Shauna E, Hyland, Niall, Clarke, Gerard, Dinan, Timothy G

“…The importance of the gut-brain axis in maintaining homeostasis has long been appreciated. However, the past 15 yr have seen the emergence of the microbiota…”
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When Rhythms Meet the Blues: Circadian Interactions with the Microbiota-Gut-Brain Axis by Teichman, Emily M., O’Riordan, Kenneth J., Gahan, Cormac G.M., Dinan, Timothy G., Cryan, John F.

“…The microbiota-gut-brain axis encompasses a bidirectional mode of communication between the microorganisms residing in our gut, and our brain function and…”
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Microbiota and sleep: awakening the gut feeling by Sen, Paromita, Molinero-Perez, Alicia, O’Riordan, Kenneth J., McCafferty, Cian P., O’Halloran, Ken D., Cryan, John F.

“…Various lifestyle and environmental factors are known to influence sleep. Increasingly, evidence points to a role for the microbiota in regulating brain and…”
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Microbial memories: Sex‐dependent impact of the gut microbiome on hippocampal plasticity by Darch, Henry T., Collins, Michael K., O’Riordan, Kenneth J., Cryan, John F.

“…Germ‐free rodents, raised in the absence of a measurable gut microbiome, have been a key model to study the microbiome‐gut‐brain axis. Germ‐free mice exhibit…”
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Towards a psychobiotic therapy for depression: Bifidobacterium breve CCFM1025 reverses chronic stress-induced depressive symptoms and gut microbial abnormalities in mice by Tian, Peijun, O'Riordan, Kenneth J., Lee, Yuan-kun, Wang, Gang, Zhao, Jianxin, Zhang, Hao, Cryan, John F., Chen, Wei

“…Accumulating evidence points to an association between gut microbial abnormalities and depression disorder. The microbiota-gut-brain axis is an emerging target…”
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Physiological activation of mGlu5 receptors supports the ion channel function of NMDA receptors in hippocampal LTD induction in vivo by O’Riordan, Kenneth J., Hu, Neng-Wei, Rowan, Michael J.

“…Synaptic long-term depression (LTD) is believed to underlie critical mnemonic processes in the adult hippocampus. The roles of the metabotropic and ionotropic…”
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Aß Facilitates LTD at Schaffer Collateral Synapses Preferentially in the Left Hippocampus by O’Riordan, Kenneth J., Hu, Neng-Wei, Rowan, Michael J.

“…Promotion of long-term depression (LTD) mechanisms by synaptotoxic soluble oligomers of amyloid-β (Aß) has been proposed to underlie synaptic dysfunction in…”
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Metabolic regulation of neuronal plasticity by the energy sensor AMPK by Potter, Wyatt B, O'Riordan, Kenneth J, Barnett, David, Osting, Susan M K, Wagoner, Matthew, Burger, Corinna, Roopra, Avtar

“…Long Term Potentiation (LTP) is a leading candidate mechanism for learning and memory and is also thought to play a role in the progression of seizures to…”
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Feeding gut microbes to nourish the brain: unravelling the diet–microbiota–gut–brain axis by Schneider, Elizabeth, O’Riordan, Kenneth J., Clarke, Gerard, Cryan, John F.

“…The prevalence of brain disorders, including stress-related neuropsychiatric disorders and conditions with cognitive dysfunction, is rising. Poor dietary…”
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Potent anti-seizure effects of D-leucine by Hartman, Adam L, Santos, Polan, O'Riordan, Kenneth J, Stafstrom, Carl E, Marie Hardwick, J

“…Abstract There are no effective treatments for millions of patients with intractable epilepsy. High-fat ketogenic diets may provide significant clinical…”
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Regulation of Histone Acetylation during Memory Formation in the Hippocampus by Levenson, Jonathan M., O'Riordan, Kenneth J., Brown, Karen D., Trinh, Mimi A., Molfese, David L., Sweatt, J. David

“…Formation of long term memory begins with the activation of many disparate signaling pathways that ultimately impinge on the cellular mechanisms regulating…”
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Reduced juvenile long-term depression in tuberous sclerosis complex is mitigated in adults by compensatory recruitment of mGluR5 and Erk signaling by Potter, Wyatt B, Basu, Trina, O'Riordan, Kenneth J, Kirchner, Allison, Rutecki, Paul, Burger, Corinna, Roopra, Avtar

“…Tuberous sclerosis complex (TSC) is a multisystem genetic disease that manifests with mental retardation, tumor formation, autism, and epilepsy. Heightened…”
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The amyloid precursor protein (APP) intracellular domain regulates translation of p44, a short isoform of p53, through an IRES-dependent mechanism by Li, Mi, Pehar, Mariana, Liu, Yan, Bhattacharyya, Anita, Zhang, Su-Chun, O'Riordan, Kenneth J, Burger, Corinna, D'Adamio, Luciano, Puglielli, Luigi

“…Abstract p44 is a short isoform of the tumor suppressor protein p53 that is regulated in an age-dependent manner. When overexpressed in the mouse, it causes a…”
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Short chain fatty acids: Microbial metabolites for gut-brain axis signalling by O'Riordan, Kenneth J., Collins, Michael K., Moloney, Gerard M., Knox, Emily G., Aburto, María R., Fülling, Christine, Morley, Shane J., Clarke, Gerard, Schellekens, Harriët, Cryan, John F.

“…The role of the intestinal microbiota as a regulator of gut-brain axis signalling has risen to prominence in recent years. Understanding the relationship…”
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Regulation of Nuclear Factor κB in the Hippocampus by Group I Metabotropic Glutamate Receptors by O’Riordan, Kenneth J., Huang, I-Chia, Pizzi, Marina, Spano, PierFranco, Boroni, Flora, Egli, Regula, Desai, Priyanka, Fitch, Olivia, Malone, Lauren, Jin Ahn, Hyung, Liou, Hsiou-Chi, Sweatt, J. David, Levenson, Jonathan M.

“…An increasing amount of evidence suggests that the family of nuclear factor κB (NF-κB) transcription factors plays an important role in synaptic plasticity and…”
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A biological framework for emotional dysregulation in alcohol misuse: from gut to brain by Carbia, Carina, Lannoy, Séverine, Maurage, Pierre, López-Caneda, Eduardo, O’Riordan, Kenneth J., Dinan, Timothy G., Cryan, John F.

“…Alcohol use disorder (AUD) has been associated with impairments in social and emotional cognition that play a crucial role in the development and maintenance…”
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Dietary phospholipids: Role in cognitive processes across the lifespan by Schverer, Marina, O'Mahony, Siobhain M., O’Riordan, Kenneth J., Donoso, Francisco, Roy, Bernard L., Stanton, Catherine, Dinan, Timothy G., Schellekens, Harriët, Cryan, John F.

“…•Dietary interventions are useful and easy tools to manipulate brain functions.•Chronic stress and ageing lead to deficits in cognitive processes in humans and…”
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NMDA and dopamine converge on the NMDA-receptor to induce ERK activation and synaptic depression in mature hippocampus by Kaphzan, Hanoch, O'Riordan, Kenneth J, Mangan, Kile P, Levenson, Jonathan M, Rosenblum, Kobi

“…The formation of enduring internal representation of sensory information demands, in many cases, convergence in time and space of two different stimuli. The…”
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