Surgical management of lobular carcinoma from a national screening program: A retrospective analysis

Abstract Objective To compare the surgical outcomes of women diagnosed with invasive ductal and lobular carcinoma of the breast. Background The role of Breast Conserving Surgery (BCS) for invasive cancers of the breast is well established; however its role for invasive lobular carcinoma is less well...

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Bibliographic Details
Published in:	European journal of surgical oncology Vol. 41; no. 1; pp. 79 - 85
Main Authors:	Sharma, S.D.J, Barry, M, O'Reilly, E.A, Kell, M.R
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-01-2015
Subjects:	Aged Breast - pathology Breast Conserving Surgery Breast Neoplasms - diagnosis Breast Neoplasms - metabolism Breast Neoplasms - surgery Carcinoma, Ductal, Breast - diagnosis Carcinoma, Ductal, Breast - metabolism Carcinoma, Ductal, Breast - surgery Carcinoma, Lobular - diagnosis Carcinoma, Lobular - metabolism Carcinoma, Lobular - surgery Early Detection of Cancer - methods Female Hematology, Oncology and Palliative Medicine Humans Invasive ductal carcinoma Invasive lobular carcinoma Ireland Mammography - methods Mastectomy - methods Mastectomy, Segmental - methods Middle Aged Neoplasm Grading Neoplasm Staging Re-excision of margins Receptor, ErbB-2 - metabolism Receptors, Estrogen - metabolism Receptors, Progesterone - metabolism Retrospective Studies Surgery Surgical oncology Treatment Outcome Tumor Burden Ireland ILC BCT BCS Breast Conserving Surgery Invasive Breast Cancer IDC Invasive ductal carcinoma Surgical oncology IBC Breast Conserving Therapy Invasive lobular carcinoma Re-excision of margins
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Summary:	Abstract Objective To compare the surgical outcomes of women diagnosed with invasive ductal and lobular carcinoma of the breast. Background The role of Breast Conserving Surgery (BCS) for invasive cancers of the breast is well established; however its role for invasive lobular carcinoma is less well defined. Concerns exist regarding the need for re-excision of margins and the eventual need for mastectomy in women with Invasive Lobular Carcinoma (ILC) compared with Ductal Carcinoma (IDC). In this study we compare the surgical results of these two groups examining BCS from a national breast cancer screening program. Methods Analysis of mammographically detected ILC and IDC tumours obtained from the national breast cancer screening program of the Republic of Ireland (BreastCheck) was performed. BreastCheck offers biannual screening mammograms to women throughout the Republic of Ireland between 50 and 65 years of age. We examined and pooled the data across 4 screening zones from 2005 to 2010. Conclusions We observed similar success rates and trends in both the ILC and IDC groups where BCS was attempted. Patients selected for BCS with ILC were statistically more likely to have successful surgery compared with IDC as tumour size increased. There however was no statistical difference in a pooled analysis of successful treatment across all tumour sizes in comparing the two groups. We conclude that BCS is an appropriate and acceptable treatment option for women diagnosed with ILC.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0748-7983 1532-2157
DOI:	10.1016/j.ejso.2014.09.004