Search Results - "O'ROURKE, M"

Honey bee hives decrease wild bee abundance, species richness, and fruit count on farms regardless of wildflower strips by Angelella, G. M., McCullough, C. T., O’Rourke, M. E.

“…Pollinator refuges such as wildflower strips are planted on farms with the goals of mitigating wild pollinator declines and promoting crop pollination…”
Get full text

Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α by Wang, Qirui, He, Zhenqiang, Huang, Menggui, Liu, Tianrun, Wang, Yanling, Xu, Haineng, Duan, Hao, Ma, Peihong, Zhang, Lin, Zamvil, Scott S., Hidalgo, Juan, Zhang, Zhenfeng, O’Rourke, Donald M., Dahmane, Nadia, Brem, Steven, Mou, Yonggao, Gong, Yanqing, Fan, Yi

“…Spatiotemporal regulation of tumor immunity remains largely unexplored. Here we identify a vascular niche that controls alternative macrophage activation in…”
Get full text

PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma by Liu, Tianrun, Ma, Wenjuan, Xu, Haineng, Huang, Menggui, Zhang, Duo, He, Zhenqiang, Zhang, Lin, Brem, Steven, O’Rourke, Donald M., Gong, Yanqing, Mou, Yonggao, Zhang, Zhenfeng, Fan, Yi

“…Angiogenesis is a hallmark of cancer. However, most malignant solid tumors exhibit robust resistance to current anti-angiogenic therapies that primarily target…”
Get full text

Clinical investigation of CAR T cells for solid tumors: Lessons learned and future directions by Bagley, Stephen J., O’Rourke, Donald M.

“…Chimeric antigen receptor (CAR) T cells are a form of autologous immunotherapy that has changed the therapeutic landscape of hematologic malignancies. CAR T…”
Get full text

Imaging Surrogates of Infiltration Obtained Via Multiparametric Imaging Pattern Analysis Predict Subsequent Location of Recurrence of Glioblastoma by Akbari, Hamed, Macyszyn, Luke, Da, Xiao, Bilello, Michel, Wolf, Ronald L., Martinez-Lage, Maria, Biros, George, Alonso-Basanta, Michelle, O'Rourke, Donald M., Davatzikos, Christos

“…Abstract BACKGROUND: Glioblastoma is an aggressive and highly infiltrative brain cancer. Standard surgical resection is guided by enhancement on postcontrast…”
Get full text

High throughput pMHC-I tetramer library production using chaperone-mediated peptide exchange by Overall, Sarah A., Toor, Jugmohit S., Hao, Stephanie, Yarmarkovich, Mark, Sara M. O’Rourke, Morozov, Giora I., Nguyen, Son, Japp, Alberto Sada, Gonzalez, Nicolas, Moschidi, Danai, Betts, Michael R., Maris, John M., Smibert, Peter, Sgourakis, Nikolaos G.

“…Peptide exchange technologies are essential for the generation of pMHC-multimer libraries used to probe diverse, polyclonal TCR repertoires in various…”
Get full text

Rapid and sensitive detection of SARS-CoV-2 antibodies by biolayer interferometry by Dzimianski, John V., Lorig-Roach, Nicholas, O’Rourke, Sara M., Alexander, David L., Kimmey, Jacqueline M., DuBois, Rebecca M.

“…Serological testing to evaluate antigen-specific antibodies in plasma is generally performed by rapid lateral flow test strips that lack quantitative results…”
Get full text

Radiomic MRI signature reveals three distinct subtypes of glioblastoma with different clinical and molecular characteristics, offering prognostic value beyond IDH1 by Rathore, Saima, Akbari, Hamed, Rozycki, Martin, Abdullah, Kalil G., Nasrallah, MacLean P., Binder, Zev A., Davuluri, Ramana V., Lustig, Robert A., Dahmane, Nadia, Bilello, Michel, O’Rourke, Donald M., Davatzikos, Christos

“…The remarkable heterogeneity of glioblastoma, across patients and over time, is one of the main challenges in precision diagnostics and treatment planning…”
Get full text

Anthropogenic habitat alteration leads to rapid loss of adaptive variation and restoration potential in wild salmon populations by Thompson, Tasha Q., Bellinger, M. Renee, O’Rourke, Sean M., Prince, Daniel J., Stevenson, Alexander E., Rodrigues, Antonia T., Sloat, Matthew R., Speller, Camilla F., Yang, Dongya Y., Butler, Virginia L., Banks, Michael A., Miller, Michael R.

“…Phenotypic variation is critical for the long-term persistence of species and populations. Anthropogenic activities have caused substantial shifts and…”
Get full text

Immune landscapes associated with different glioblastoma molecular subtypes by Martinez-Lage, Maria, Lynch, Timothy M, Bi, Yingtao, Cocito, Carolina, Way, Gregory P, Pal, Sharmistha, Haller, Josephine, Yan, Rachel E, Ziober, Amy, Nguyen, Aivi, Kandpal, Manoj, O'Rourke, Donald M, Greenfield, Jeffrey P, Greene, Casey S, Davuluri, Ramana V, Dahmane, Nadia

“…Recent work has highlighted the tumor microenvironment as a central player in cancer. In particular, interactions between tumor and immune cells may help drive…”
Get full text

Definition, Determinants, and Outcomes of Social Connectedness for Older Adults: A Scoping Review by O'Rourke, Hannah M, Sidani, Souraya

“…Social connectedness is critical to older adults' well-being, but is defined inconsistently and its determinants and outcomes have not been comprehensively…”
Get more information

CAR T-cell therapy for glioblastoma: recent clinical advances and future challenges by Bagley, Stephen J, Desai, Arati S, Linette, Gerald P, June, Carl H, O'Rourke, Donald M

“…In patients with certain hematologic malignancies, the use of autologous T cells genetically modified to express chimeric antigen receptors (CARs) has led to…”
Get full text

Glioblastoma: The Current State of Biology and Therapeutic Strategies by Binder, Zev A, O'Rourke, Donald M

“…Over the past two decades, there have been advances in surgical technologies and chemoradiation strategies for glioblastoma, yet durable remissions are rarely…”
Get full text

A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity by Jacob, Fadi, Salinas, Ryan D., Zhang, Daniel Y., Nguyen, Phuong T.T., Schnoll, Jordan G., Wong, Samuel Zheng Hao, Thokala, Radhika, Sheikh, Saad, Saxena, Deeksha, Prokop, Stefan, Liu, Di-ao, Qian, Xuyu, Petrov, Dmitriy, Lucas, Timothy, Chen, H. Isaac, Dorsey, Jay F., Christian, Kimberly M., Binder, Zev A., Nasrallah, MacLean, Brem, Steven, O’Rourke, Donald M., Ming, Guo-li, Song, Hongjun

“…Glioblastomas exhibit vast inter- and intra-tumoral heterogeneity, complicating the development of effective therapeutic strategies. Current in vitro models…”
Get full text

IDH mutation impairs histone demethylation and results in a block to cell differentiation by Lu, Chao, Ward, Patrick S., Kapoor, Gurpreet S., Rohle, Dan, Turcan, Sevin, Abdel-Wahab, Omar, Edwards, Christopher R., Khanin, Raya, Figueroa, Maria E., Melnick, Ari, Wellen, Kathryn E., O’Rourke, Donald M., Berger, Shelley L., Chan, Timothy A., Levine, Ross L., Mellinghoff, Ingo K., Thompson, Craig B.

“…Cancer-associated IDH mutants that produce 2-hydroxyglutarate are shown to prevent the histone demethylation that is required for lineage-specific progenitor…”
Get full text

Circulating Glioma Cells Exhibit Stem Cell-like Properties by Liu, Tianrun, Xu, Haineng, Huang, Menggui, Ma, Wenjuan, Saxena, Deeksha, Lustig, Robert A, Alonso-Basanta, Michelle, Zhang, Zhenfeng, O'Rourke, Donald M, Zhang, Lin, Gong, Yanqing, Kao, Gary D, Dorsey, Jay F, Fan, Yi

“…: Circulating tumor cells (CTC) are known to be present in the blood of patients with glioblastoma (GBM). Here we report that GBM-derived CTC possess a cancer…”
Get full text

Epidermal Growth Factor Receptor Extracellular Domain Mutations in Glioblastoma Present Opportunities for Clinical Imaging and Therapeutic Development by Binder, Zev A., Thorne, Amy Haseley, Bakas, Spyridon, Wileyto, E. Paul, Bilello, Michel, Akbari, Hamed, Rathore, Saima, Ha, Sung Min, Zhang, Logan, Ferguson, Cole J., Dahiya, Sonika, Bi, Wenya Linda, Reardon, David A., Idbaih, Ahmed, Felsberg, Joerg, Hentschel, Bettina, Weller, Michael, Bagley, Stephen J., Morrissette, Jennifer J.D., Nasrallah, MacLean P., Ma, Jianhui, Zanca, Ciro, Scott, Andrew M., Orellana, Laura, Davatzikos, Christos, Furnari, Frank B., O'Rourke, Donald M.

“…We explored the clinical and pathological impact of epidermal growth factor receptor (EGFR) extracellular domain missense mutations. Retrospective assessment…”
Get full text

Histopathology‐validated machine learning radiographic biomarker for noninvasive discrimination between true progression and pseudo‐progression in glioblastoma by Akbari, Hamed, Rathore, Saima, Bakas, Spyridon, Nasrallah, MacLean P., Shukla, Gaurav, Mamourian, Elizabeth, Rozycki, Martin, Bagley, Stephen J., Rudie, Jeffrey D., Flanders, Adam E., Dicker, Adam P., Desai, Arati S., O’Rourke, Donald M., Brem, Steven, Lustig, Robert, Mohan, Suyash, Wolf, Ronald L., Bilello, Michel, Martinez‐Lage, Maria, Davatzikos, Christos

“…Background Imaging of glioblastoma patients after maximal safe resection and chemoradiation commonly demonstrates new enhancements that raise concerns about…”
Get full text

A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma by O'Rourke, Donald M, Nasrallah, MacLean P, Desai, Arati, Melenhorst, Jan J, Mansfield, Keith, Morrissette, Jennifer J D, Martinez-Lage, Maria, Brem, Steven, Maloney, Eileen, Shen, Angela, Isaacs, Randi, Mohan, Suyash, Plesa, Gabriela, Lacey, Simon F, Navenot, Jean-Marc, Zheng, Zhaohui, Levine, Bruce L, Okada, Hideho, June, Carl H, Brogdon, Jennifer L, Maus, Marcela V

“…We conducted a first-in-human study of intravenous delivery of a single dose of autologous T cells redirected to the epidermal growth factor receptor variant…”
Get more information

Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau by Darwich, Nabil F, Phan, Jessica M, Kim, Boram, Suh, EunRan, Papatriantafyllou, John D, Changolkar, Lakshmi, Nguyen, Aivi T, O'Rourke, Caroline M, He, Zhuohao, Porta, Sílvia, Gibbons, Garrett S, Luk, Kelvin C, Papageorgiou, Sokratis G, Grossman, Murray, Massimo, Lauren, Irwin, David J, McMillan, Corey T, Nasrallah, Ilya M, Toro, Camilo, Aguirre, Geoffrey K, Van Deerlin, Vivianna M, Lee, Edward B

“…Neurodegeneration in Alzheimer's disease (AD) is closely associated with the accumulation of pathologic tau aggregates in the form of neurofibrillary tangles…”
Get full text