Search Results - "O'Neill, Luke A."

Metabolic reprogramming in macrophages and dendritic cells in innate immunity by Kelly, Beth, O'Neill, Luke AJ

“…Activation of macrophages and dendritic cells （DCs） by pro-inflammatory stimuli causes them to undergo a metabolic switch towards glycolysis and away from…”
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Reprogramming mitochondrial metabolism in macrophages as an anti‐inflammatory signal by Mills, Evanna L., O'Neill, Luke A.

“…Mitochondria are master regulators of metabolism. Mitochondria generate ATP by oxidative phosphorylation using pyruvate (derived from glucose and glycolysis)…”
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The history of Toll-like receptors — redefining innate immunity by O'Neill, Luke A. J., Golenbock, Douglas, Bowie, Andrew G.

“…The past 15 years have seen a breakthrough in the field of innate immunity. In this Timeline article, the authors discuss the early events that led to the…”
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Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome by Neudecker, Viola, Haneklaus, Moritz, Jensen, Owen, Khailova, Ludmila, Masterson, Joanne C, Tye, Hazel, Biette, Kathryn, Jedlicka, Paul, Brodsky, Kelley S, Gerich, Mark E, Mack, Matthias, Robertson, Avril A B, Cooper, Matthew A, Furuta, Glenn T, Dinarello, Charles A, O'Neill, Luke A, Eltzschig, Holger K, Masters, Seth L, McNamee, Eóin N

“…MicroRNA (miRNA)-mediated RNA interference regulates many immune processes, but how miRNA circuits orchestrate aberrant intestinal inflammation during…”
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Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming by Olagnier, David, Brandtoft, Aske M., Gunderstofte, Camilla, Villadsen, Nikolaj L., Krapp, Christian, Thielke, Anne L., Laustsen, Anders, Peri, Suraj, Hansen, Anne Louise, Bonefeld, Lene, Thyrsted, Jacob, Bruun, Victor, Iversen, Marie B., Lin, Lin, Artegoitia, Virginia M., Su, Chenhe, Yang, Long, Lin, Rongtuan, Balachandran, Siddharth, Luo, Yonglun, Nyegaard, Mette, Marrero, Bernadette, Goldbach-Mansky, Raphaela, Motwani, Mona, Ryan, Dylan G., Fitzgerald, Katherine A., O’Neill, Luke A., Hollensen, Anne K., Damgaard, Christian K., de Paoli, Frank v., Bertram, Hanne C., Jakobsen, Martin R., Poulsen, Thomas B., Holm, Christian K.

“…The transcription factor Nrf2 is a critical regulator of inflammatory responses. If and how Nrf2 also affects cytosolic nucleic acid sensing is currently…”
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Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages by Mills, Evanna L., Kelly, Beth, Logan, Angela, Costa, Ana S.H., Varma, Mukund, Bryant, Clare E., Tourlomousis, Panagiotis, Däbritz, J. Henry M., Gottlieb, Eyal, Latorre, Isabel, Corr, Sinéad C., McManus, Gavin, Ryan, Dylan, Jacobs, Howard T., Szibor, Marten, Xavier, Ramnik J., Braun, Thomas, Frezza, Christian, Murphy, Michael P., O’Neill, Luke A.

“…Activated macrophages undergo metabolic reprogramming, which drives their pro-inflammatory phenotype, but the mechanistic basis for this remains obscure. Here,…”
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A Broken Krebs Cycle in Macrophages by O’Neill, Luke A.J.

“…Macrophages undergo metabolic rewiring during polarization but details of this process are unclear. In this issue of Immunity, Jha et al. (2015) report a…”
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Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity by Arts, Rob J.W., Novakovic, Boris, ter Horst, Rob, Carvalho, Agostinho, Bekkering, Siroon, Lachmandas, Ekta, Rodrigues, Fernando, Silvestre, Ricardo, Cheng, Shih-Chin, Wang, Shuang-Yin, Habibi, Ehsan, Gonçalves, Luís G., Mesquita, Inês, Cunha, Cristina, van Laarhoven, Arjan, van de Veerdonk, Frank L., Williams, David L., van der Meer, Jos W.M., Logie, Colin, O'Neill, Luke A., Dinarello, Charles A., Riksen, Niels P., van Crevel, Reinout, Clish, Clary, Notebaart, Richard A., Joosten, Leo A.B., Stunnenberg, Hendrik G., Xavier, Ramnik J., Netea, Mihai G.

“…Induction of trained immunity (innate immune memory) is mediated by activation of immune and metabolic pathways that result in epigenetic rewiring of cellular…”
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interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress by O'Neill, Luke A.J

“…The interleukin-1 receptor (IL-1R)/Toll-like receptor (TLR) superfamily was first defined in 1998 as a family of proteins that contain the Toll-IL-1 receptor…”
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The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling by O'Neill, Luke A. J, Bowie, Andrew G

“…Signalling by Toll-like receptors (TLRs) involves five adaptor proteins known as MyD88, MAL, TRIF, TRAM and SARM. Recent insights have revealed additional…”
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Cutting edge: miR-223 and EBV miR-BART15 regulate the NLRP3 inflammasome and IL-1β production by Haneklaus, Moritz, Gerlic, Motti, Kurowska-Stolarska, Mariola, Rainey, Ashleigh-Ann, Pich, Dagmar, McInnes, Iain B, Hammerschmidt, Wolfgang, O'Neill, Luke A J, Masters, Seth L

“…Although microRNA (miRNA) regulation of TLR signaling is well established, this has not yet been observed for NLR proteins or the inflammasomes they form. We…”
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The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype by Basiorka, Ashley A., McGraw, Kathy L., Eksioglu, Erika A., Chen, Xianghong, Johnson, Joseph, Zhang, Ling, Zhang, Qing, Irvine, Brittany A., Cluzeau, Thomas, Sallman, David A., Padron, Eric, Komrokji, Rami, Sokol, Lubomir, Coll, Rebecca C., Robertson, Avril A.B., Cooper, Matthew A., Cleveland, John L., O'Neill, Luke A., Wei, Sheng, List, Alan F.

“…Despite genetic heterogeneity, myelodysplastic syndromes (MDSs) share features of cytological dysplasia and ineffective hematopoiesis. We report that a…”
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NLRP3 at the interface of metabolism and inflammation by Haneklaus, Moritz, O'Neill, Luke A. J.

“…Summary The discovery of the NLRP3 (NLR family, pyrin domain containing 3) inflammasome provided an important molecular mechanism in the induction of the…”
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Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 by Mills, Evanna L., Ryan, Dylan G., Prag, Hiran A., Dikovskaya, Dina, Menon, Deepthi, Zaslona, Zbigniew, Jedrychowski, Mark P., Costa, Ana S. H., Higgins, Maureen, Hams, Emily, Szpyt, John, Runtsch, Marah C., King, Martin S., McGouran, Joanna F., Fischer, Roman, Kessler, Benedikt M., McGettrick, Anne F., Hughes, Mark M., Carroll, Richard G., Booty, Lee M., Knatko, Elena V., Meakin, Paul J., Ashford, Michael L. J., Modis, Louise K., Brunori, Gino, Sévin, Daniel C., Fallon, Padraic G., Caldwell, Stuart T., Kunji, Edmund R. S., Chouchani, Edward T., Frezza, Christian, Dinkova-Kostova, Albena T., Hartley, Richard C., Murphy, Michael P., O’Neill, Luke A.

“…WebTreatment of lipopolysaccharide-activated macrophages with the cell-permeable itaconate derivative 4-octyl itaconate activates the anti-inflammatory…”
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Cutting Edge: Mycobacterium tuberculosis Induces Aerobic Glycolysis in Human Alveolar Macrophages That Is Required for Control of Intracellular Bacillary Replication by Gleeson, Laura E, Sheedy, Frederick J, Palsson-McDermott, Eva M, Triglia, Denise, O'Leary, Seonadh M, O'Sullivan, Mary P, O'Neill, Luke A J, Keane, Joseph

“…Recent advances in immunometabolism link metabolic changes in stimulated macrophages to production of IL-1β, a crucial cytokine in the innate immune response…”
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Localisation and trafficking of Toll-like receptors: an important mode of regulation by McGettrick, Anne F, O’Neill, Luke AJ

“…In recent years the importance of the localisation and trafficking of Toll-like receptors (TLRs) and their adaptors within the cell has become apparent…”
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Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments by Haneklaus, Moritz, O’Neill, Luke AJ, Coll, Rebecca C

“…Highlights ► Overview of the control of NLRP3 activity by the cellular redox environment. ► miRNA-223 and viral factors can inhibit NLRP3. ► Kinase and calcium…”
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A trio of microRNAs that control Toll-like receptor signalling by Quinn, Susan R., O'Neill, Luke A.

“…Toll-like receptors (TLRs) in the host recognize conserved microbial products and defend against pathogenic attack by initiating an immune response via…”
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A guiding map for inflammation by Netea, Mihai G, Balkwill, Frances, Chonchol, Michel, Cominelli, Fabio, Donath, Marc Y, Giamarellos-Bourboulis, Evangelos J, Golenbock, Douglas, Gresnigt, Mark S, Heneka, Michael T, Hoffman, Hal M, Hotchkiss, Richard, Joosten, Leo A B, Kastner, Daniel L, Korte, Martin, Latz, Eicke, Libby, Peter, Mandrup-Poulsen, Thomas, Mantovani, Alberto, Mills, Kingston H G, Nowak, Kristen L, O'Neill, Luke A, Pickkers, Peter, van der Poll, Tom, Ridker, Paul M, Schalkwijk, Joost, Schwartz, David A, Siegmund, Britta, Steer, Clifford J, Tilg, Herbert, van der Meer, Jos W M, van de Veerdonk, Frank L, Dinarello, Charles A

“…Netea and colleagues provide a general guide to the cellular and humoral contributors to inflammation as well as the pathways that characterize inflammation in…”
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Negative regulation of Toll-like receptor-mediated immune responses by Liew, Foo Y, Xu, Damo, Brint, Elizabeth K, O'Neill, Luke A. J

“…Toll-like receptors (TLRs) are involved in host defence against invading pathogens, functioning as primary sensors of microbial products and activating…”
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