Search Results - "O'Neill, Jacqueline A."

Identification of Novel Ligands for the Gabapentin Binding Site on the α2δ Subunit of a Calcium Channel and Their Evaluation as Anticonvulsant Agents by Bryans, Justin S, Davies, Natasha, Gee, Nicolas S, Dissanayake, Visaka U. K, Ratcliffe, Giles S, Horwell, David C, Kneen, Clare O, Morrell, Andrew I, Oles, Ryszard J, O'Toole, John C, Perkins, Gemma M, Singh, Lakhbir, Suman-Chauhan, Nirmala, O'Neill, Jacqueline A

“…As part of a program to investigate the structure−activity relationships of Gabapentin (Neurontin), a number of alkylated analogues were synthesized and…”
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Design of a structural motif ‘dendroid’ to mimic protein: Protein interactions via intramolecular self-organisation by Allen, Joanne V, Horwell, David C, Lainton Julia A H, O'Neill, Jacqueline A, Ratcliffe, Giles S

“…SummaryThe design and synthesis of a structural motif which can mimic protein-protein interactions is described. These moieties, termed asdendroids…”
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Investigation into the preferred conformation of gabapentin for interaction with its binding site on the α2δ subunit of a calcium channel by Bryans, Justin S., Davies, Natasha, Gee, Nicolas S., Horwell, David C., Kneen, Clare O., Morrell, Andrew I., O'Neill, Jacqueline A., Ratcliffe, Giles S.

“…A series of conformationally restricted Gabapentin analogues has been synthesised and used to propose the preferred conformation of Gabapentin for it to bind…”
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Identification of Novel Ligands for the Gabapentin Binding Site on the α 2 δ Subunit of a Calcium Channel and Their Evaluation as Anticonvulsant Agents by Bryans, Justin S., Davies, Natasha, Gee, Nicolas S., Dissanayake, Visaka U. K., Ratcliffe, Giles S., Horwell, David C., Kneen, Clare O., Morrell, Andrew I., Oles, Ryszard J., O'Toole, John C., Perkins, Gemma M., Singh, Lakhbir, Suman-Chauhan, Nirmala, O'Neill, Jacqueline A.

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