Search Results - "O'Neill, J S"

Association of IL-10 polymorphism with severity of illness in community acquired pneumonia by Gallagher, P M, Lowe, G, Fitzgerald, T, Bella, A, Greene, C M, McElvaney, N G, O’Neill, S J

“…Background: The influence of genetic polymorphisms of interleukin (IL)-10, tumour necrosis factor (TNF)-α, and IL-6 gene promoters on severity of systemic…”
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Alpha-1 antitrypsin deficiency: A conformational disease associated with lung and liver manifestations by Greene, C. M., Miller, S. D. W., Carroll, T., McLean, C., O’Mahony, M., Lawless, M. W., O’Neill, S. J., Taggart, C. C., McElvaney, N. G.

“…Summary Alpha-1 antitrypsin (A1AT) is a serine anti-protease produced chiefly by the liver. A1AT deficiency is a genetic disorder characterized by serum levels…”
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Ambient pCO2 modulates intracellular pH, intracellular oxidant generation, and interleukin-8 secretion in human neutrophils by Coakley, R. J., Taggart, C, Greene, C, McElvaney, N. G, O’Neill, S. J.

“…Although neutrophils are a critical component of the inflammatory process, their functional regulation is incompletely understood. Of note, although pCO2…”
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A deceiving wheeze by Chotirmall, S. H., Branagan, P., Logan, M. P., O’Neill, S. J.

“…‘Wheeze’ is a common symptom in both paediatric and adult populations. Unexplained wheeze is concerning and warrants investigation. We present a case of a…”
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Cry1 Circadian Phase in vitro: Wrapped Up with an E-Box by Fustin, J.M, O'Neill, J.S, Hastings, M.H, Hazlerigg, D.G, Dardente, H

“…The circadian timing of gene expression is determined by transcriptional regulation through upstream response elements present throughout the genome. Central…”
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Genetic and molecular analysis of the central and peripheral circadian clockwork of mice by Maywood, E S, O'Neill, J S, Reddy, A B, Chesham, J E, Prosser, H M, Kyriacou, C P, Godinho, S I H, Nolan, P M, Hastings, M H

“…A hierarchy of interacting, tissue-based clocks controls circadian physiology and behavior in mammals. Preeminent are the suprachiasmatic nuclei (SCN): central…”
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MRI scanning and orthodontics by Patel, A, Bhavra, G. S, O'Neill, J. R. S

“…Magnetic Resonance Imaging (MRI) plays an important role in diagnosis for many head and neck lesions. Both clinical and experimental studies have shown that…”
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Role of IL-18 in CD4+ T Lymphocyte Activation in Sarcoidosis by Greene, Catherine M, Meachery, Gerard, Taggart, Clifford C, Rooney, Cyril P, Coakley, Raymond, O'Neill, Shane J, McElvaney, Noel G

“…Sarcoidosis is a granulomatous disease of unknown etiology associated with the expansion of IL-2-producing activated CD4(+) T lymphocytes. A number of factors…”
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Acute effects of hypoxaemia, hyperoxaemia and hypercapnia on renal blood flow in normal and renal transplant subjects by Sharkey, RA, Mulloy, EM, O'Neill, SJ

“…The aim of this investigation was to study noninvasively the effects of hypoxaemia, hyperoxaemia and hypercapnia on renal blood flow in normal subjects and…”
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Synchronization and Maintenance of Timekeeping in Suprachiasmatic Circadian Clock Cells by Neuropeptidergic Signaling by Maywood, Elizabeth S., Reddy, Akhilesh B., Wong, Gabriel K.Y., O'Neill, John S., O'Brien, John A., McMahon, Douglas G., Harmar, Anthony J., Okamura, Hitoshi, Hastings, Michael H.

“…Circadian timekeeping in mammals is driven by transcriptional/posttranslational feedback loops [1] that are active within both peripheral tissues and the…”
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Alpha-1-antitrypsin aerosolised augmentation abrogates neutrophil elastase-induced expression of cathepsin B and matrix metalloprotease 2 in vivo and in vitro by Geraghty, P, Rogan, M P, Greene, C M, Brantly, M L, O'Neill, S J, Taggart, C C, McElvaney, N G

“…Neutrophil elastase (NE) activity is increased in lung diseases such as alpha(1)-antitrypsin (A1AT) deficiency and pneumonia. It has recently been shown to…”
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The acute effects of oxygen and carbon dioxide on renal vascular resistance in patients with an acute exacerbation of COPD by Sharkey, R A, Mulloy, E M, O'Neill, S J

“…Changes in renal hemodynamics occur in patients with severe COPD, especially during an acute exacerbation. Renal hemodynamics are affected by changes in oxygen…”
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Renal functional reserve in patients with severe chronic obstructive pulmonary disease by Sharkey, R A, Mulloy, E M, Kilgallen, I A, O'Neill, S J

“…BACKGROUND: Renal functional reserve is the normal increase in renal blood flow after a protein load, and reduced or absent renal functional reserve is an…”
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Reclaiming “Natural Partnership and Communication”: Francisco de Vitoria’s Legacy for Today’s Refugee Challenges by O’Neill, Brett

“…Abstract The massive scale of forced displacement across the globe discloses the fractured state of the modern international order. Francisco de Vitoria’s…”
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Neutrophil elastase up-regulates interleukin-8 via toll-like receptor 4 by Devaney, James M, Greene, Catherine M, Taggart, Clifford C, Carroll, Tomás P, O’Neill, Shane J, McElvaney, Noel G

“…Cystic fibrosis is characterised in the lungs by high levels of neutrophil elastase (NE). NE induces interleukin-8 (IL-8) expression via an IL-1…”
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Aromatase activity in breast adipose tissue from women with benign and malignant breast diseases by O'NEILL, J. S, MILLER, W. R

“…In order to determine the significance of local oestrogen biosynthesis within the breast, aromatase activity has been measured in adipose tissue from the…”
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Loss of Microbicidal Activity and Increased Formation of Biofilm Due to Decreased Lactoferrin Activity in Patients with Cystic Fibrosis by Rogan, Mark P., Taggart, Clifford C., Greene, Catherine M., Murphy, Philip G., O'Neill, Shane J., McElvaney, Noel G.

“…Intractable formation of biofilm by and infection with the opportunistic pathogen Pseudomonas aeruginosa are hallmarks of cystic fibrosis (CF). Lactoferrin, an…”
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Aromatase activity in adipose tissue from breast quadrants: a link with tumour site by O'Neill, John S, Elton, Robert A, Miller, William R

“…To determine the importance of local oestrogen biosynthesis within the breast, aromatase activity was measured in adipose tissue from the breast quadrants of…”
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Effect of growth hormone on human alveolar macrophage oxidative metabolism by KEANE, M. P, COAKLEY, R, COSTELLO, R, O'NEILL, S. J

“…Growth hormone (GH) has diverse immunological actions and has been shown to augment oxidative metabolism in rat peritoneal and porcine alveolar macrophages and…”
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Cathepsin B, L, and S Cleave and Inactivate Secretory Leucoprotease Inhibitor by Taggart, Clifford C., Lowe, Gregory J., Greene, Catherine M., Mulgrew, Alan T., O'Neill, Shane J., Levine, Rodney L., McElvaney, Noel G.

“…A number of serine proteases, matrix metalloproteases, and cysteine proteases were evaluated for their ability to cleave and inactivate the…”
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