Search Results - "O'Neill, I K"

Quantitation of DNA from exfoliated colonocytes isolated from human stool surface as a novel noninvasive screening test for colorectal cancer by LOKTIONOV, A, O'NEILL, I. K, SILVESTER, K. R, CUMMINGS, J. H, MIDDLETON, S. J, MILLER, R

“…The only widely used screening test for early detection of colorectal cancer, the fecal occult blood test, lacks both sensitivity and specificity because it…”
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Apolipoprotein E and methylenetetrahydrofolate reductase genetic polymorphisms in relation to other risk factors for cardiovascular disease in UK Caucasians and Black South Africans by Loktionov, Alexandre, Vorster, Hester, O'Neill, Ian K., Nell, Theo, Bingham, Sheila A., Runswick, Shirley A., Cummings, John H.

“…Genetic polymorphisms for apolipoprotein E (apo E) and methylenetetrahydrofolate reductase (MTHFR) are believed to modulate risk of coronary heart disease…”
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Does increased endogenous formation of N-nitroso compounds in the human colon explain the association between red meat and colon cancer? by Bingham, S.A., Pignatelli, B., Pollock, J.R.A., Ellul, A., Malaveille, C., Gross, G., Runswick, S., Cummings, J.H., O'Neill, I.K.

“…High red meat diets have been linked with risk of sporadic colorectal cancer, but their effects on mutations which occur in this cancer are unknown. G→A…”
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Effects of risk-associated human dietary macrocomponents on processes related to carcinogenesis in human-flora-associated (HFA) rats by Rumney, C J, Rowland, I R, Coutts, T M, Randerath, K, Reddy, R, Shah, A B, Ellul, A, O'Neill, I K

“…Dietary fat, protein and fibre have been shown to modulate cancer risk in humans and the present study examined the biological effects in…”
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Dietary fibre, fat and beef modulation of colonic nuclear aberrations and microcapsule-trapped gastrointestinal metabolites of benzo[a]pyrene-treated C57/B6 mice consuming human diets by O'Neill, I K, Goldberg, M T, el Ghissassi, F, Rojas-Moreno, M

“…Male C57/B6 mice were adapted to human diets of British origin that had 3-fold differences in either dietary fibre, fat or beef protein within the normal human…”
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Conversion of IQ to 7-OHIQ by gut microflora by Rumney, C J, Rowland, I R, O'Neill, I K

“…The rates of conversion of 2-amino-3-methyl-3H-imidazo[4,5-f]quinoline (IQ) to its reportedly mutagenic 7-keto derivative (7-OHIQ) by intestinal bacteria from…”
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Magnetic polyethyleneimine (PEI) microcapsules as retrievable traps for carcinogen electrophiles formed in the gastrointestinal tract by Povey, A C, Bartsch, H, O'Neill, I K

“…Semi-permeable magnetic microcapsules containing polyethyleneimine (PEI) have been developed as retrievable carcinogen traps. In vitro, the soluble core PEI…”
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Binding of benzo[a]pyrene metabolites in the rat intestinal lumen by magnetic polyethyleneimine microcapsules following an intragastric dose of [14C]benzo[a]pyrene by Povey, A C, Brouet, I, Bartsch, H, O'Neill, I K

“…Semi-permeable magnetic polyethyleneimine (PEI) microcapsules have been developed to trap carcinogens and their metabolites in vivo and their time-dependent…”
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Modulating effects in human diets of dietary fibre and beef, and of time and dose on the reactive microcapsule trapping of benzo[a]pyrene metabolites in the rat gastrointestinal tract by O'Neill, I K, Bingham, S, Povey, A C, Brouet, I, Bereziat, J C

“…Trapping by magnetic polyethyleneimine (PEI) microcapsules was utilized to investigate the influence in male rats of dose, human dietary composition and…”
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Trapping of chemical carcinogens with magnetic polyethyleneimine microcapsules: I. Microcapsule preparation and in vitro reactivity of encapsulated nucleophiles by Povey, A C, Bartsch, H, Nixon, J R, O'Neill, I K

“…In this paper we describe the synthesis and characterization of magnetic microcapsules, intended for use in vivo, and which contain polyethyleneimine…”
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Trapping of chemical carcinogens with magnetic polyethyleneimine microcapsules: III. In vivo trapping of electrophiles from N-methyl-N-nitrosourea and recovery from feces by Povey, A C, Brouet, I, Nixon, J R, O'Neill, I K

“…The use of semipermeable magnetic polyethyleneimine (PEI) microcapsules for trapping carcinogens in vivo is described. After intragastric administration to…”
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Occurrence in human urine of new sulphur-containing N-nitrosamino acids N-nitrosothiazolidine-4-carboxylic acid and its 2-methyl derivative, and their formation by OHSHIMA, H, ÓNEILL, I. K, FRIESEN, M, BEREZIAT, J.-C, BARTSCH, H

“…To quantitate endogenous nitrosation reactions in man, the quantity of N-nitrosoproline (NPRO) excreted in the urine after ingestion of proline and/or nitrate…”
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Trapping of chemical carcinogens with magnetic polyethyleneimine microcapsules: II. Effect of membrane and reactant structures by Povey, A C, Nixon, J R, O'Neill, I K

“…Effects of the membrane structure and reactant type on the trapping of carcinogens and other reactive species by semipermeable magnetic polyethyleneimine (PEI)…”
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New adducts of chloroethylene oxide and chloroacetaldehyde with pyrimidine nucleosides by Barbin, A, Friesen, M, O'Neill, I K, Croisy, A, Bartsch, H

“…Pyrimidine nucleosides were treated with chloroethylene oxide (CEO) and 2-chloroacetaldehyde (CAA) in methanol and, following trimethylsilylation, the products…”
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Magnetic semi-permeable polyethyleneimine microcapsules for monitoring of N-nitrosation in the gastrointestinal tract by O'Neill, I K, Castegnaro, M, Brouet, I, Povey, A C

“…Semi-permeable polyethyleneimine (PEI) microcapsules were developed recently for trapping unstable electrophilic products in the gastrointestinal tract. Their…”
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Nucleophilic selectivity and reaction kinetics of chloroethylene oxide assessed by the 4-(p-nitrobenzyl)pyridine assay and proton nuclear magnetic resonance spectroscopy by Barbin, A, Béréziat, J C, Croisy, A, O'Neill, I K, Bartsch, H

“…The nucleophilic selectivity (Swain-Scott's constant s) of chloroethylene oxide (CEO), an ultimate carcinogenic metabolite of vinyl chloride, was determined to…”
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Effect of meat and resistant starch on fecal excretion of apparent N-nitroso compounds and ammonia from the human large bowel by Silvester, K.R, Bingham, S.A, Pollock, J.R.A, Cummings, J.H, O'Neill, I.K

“…N-nitroso compounds are produced in the human large intestine, but little is known about the dietary modulation of their synthesis at this site. The effects of…”
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Determination of L-hydroxyproline in meat protein by quantitative carbon-13 Fourier transform nuclear magnetic resonance spectrometry by Jozefowicz, M. L, O'Neill, I. K, Prosser, H. J

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Comparison of metabolic effects of vegetables and teas with colorectal proliferation and with tumour development in DMH-treated F344 rats by O'Neill, I.K., Loktionov, A., Manson, M.M., Ball, H., Bandaletova, T., Bingham, S.A.

“…The aim of this study was to screen potentially chemopreventive vegetables and teas for their effects as human dietary components for the colorectal epithelium…”
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Copper phthalocyanine labelled magnetic microcapsules: preparation, and binding properties in vitro and in vivo for mutagens having planar molecular structure by Povey, A C, O'Neill, I K

“…Copper phthalocyanine tetrasulphonic acid (CPTS) functions were introduced into magnetic semi-permeable polyethyleneimine (PEI) microcapsules in order to…”
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