Search Results - "O'Neill, Edward"

The roles of ions on bone regeneration by O’Neill, Edward, Awale, Guleid, Daneshmandi, Leila, Umerah, Obum, Lo, Kevin W.-H.

“…•Alternative bone regenerative therapeutics are needed.•Ions have been proposed to regenerate skeletal tissue.•Drug delivery systems have been studied to…”
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Combination Strategies to Improve Targeted Radionuclide Therapy by Chan, Tiffany G, O'Neill, Edward, Habjan, Christine, Cornelissen, Bart

“…In recent years, targeted radionuclide therapy (TRT) has emerged as a promising strategy for cancer treatment. In contrast to conventional radiotherapy, TRT…”
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Considerations for the development of cost‐effective cell culture media for cultivated meat production by O'Neill, Edward N., Cosenza, Zachary A., Baar, Keith, Block, David E.

“…Innovation in cultivated meat development has been rapidly accelerating in recent years because it holds the potential to help attenuate issues facing…”
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Imaging DNA damage response by γH2AX in vivo predicts treatment response to Lutetium-177 radioligand therapy and suggests senescence as a therapeutically desirable outcome by O'Neill, Edward, Mosley, Michael, Cornelissen, Bart

“…An effective absorbed dose response relationship is yet to be established for Lutetium-177 based radionuclide therapies such as Lu-DOTATATE and Lu-PSMA. The…”
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S3540 Protein Losing Enteropathy in Biopsy Proven Gastrointestinal AL Amyloidosis by Gosnell, Heather, Tessiatore, Kristen, Bhaskar, Sonya, Pearce, Richard, O'Neill, Edward B., Manski, Scott

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Hypoxia-Responsive Cobalt Complexes in Tumor Spheroids: Laser Ablation Inductively Coupled Plasma Mass Spectrometry and Magnetic Resonance Imaging Studies by O’Neill, Edward S, Kaur, Amandeep, Bishop, David P, Shishmarev, Dmitry, Kuchel, Philip W, Grieve, Stuart M, Figtree, Gemma A, Renfrew, Anna K, Bonnitcha, Paul D, New, Elizabeth J

“…Dense tumors are resistant to conventional chemotherapies due to the unique tumor microenvironment characterized by hypoxic regions that promote cellular…”
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High pressure processing for raw meat in combination with other treatments: A review by Rajendran, Sasireka, Mallikarjunan, P. Kumar, O’Neill, Edward

“…High pressure processing (HPP) is a well‐known technology for nonthermal pasteurization of food materials. High pressures above 100 MPa is proven to cause…”
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Orally Bioavailable Macrocyclic Peptide That Inhibits Binding of PCSK9 to the Low Density Lipoprotein Receptor by Johns, Douglas G., Campeau, Louis-Charles, Banka, Puja, Bautmans, An, Bueters, Tjerk, Bianchi, Elisabetta, Branca, Danila, Bulger, Paul G., Crevecoeur, Inne, Ding, Fa-Xiang, Garbaccio, Robert M., Guetschow, Erik D., Guo, Yan, Ha, Sookhee N., Johnston, Jennifer M., Josien, Hubert, Kauh, Eunkyung A., Koeplinger, Kenneth A., Kuethe, Jeffrey T., Lai, Eseng, Lanning, Christine L., Lee, Anita Y.H., Li, Li, Nair, Anilkumar G., O’Neill, Edward A., Stoch, S. Aubrey, Thaisrivongs, David A., Tucker, Thomas J., Vachal, Petr, van Dyck, Kristien, Vanhoutte, Frederic P., Volckaert, Bram, Wolford, Dennis G., Xu, Andy, Zhao, Tian, Zhou, Dan, Zhou, Susan, Zhu, Xiaohong, Zokian, Hratch J., Walji, Abbas M., Wood, Harold B.

“…Inhibition of PCSK9 (proprotein convertase subtilisin/kexin type 9)-low density lipoprotein receptor interaction with injectable monoclonal antibodies or small…”
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Spent media analysis suggests cultivated meat media will require species and cell type optimization by O’Neill, Edward N., Ansel, Joshua C., Kwong, Grace A., Plastino, Michael E., Nelson, Jenny, Baar, Keith, Block, David E.

“…Cell culture media design is perhaps the most significant hurdle currently facing the commercialization of cultivated meat as an alternative source of dietary…”
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Drawing on biology to inspire molecular design: a redox-responsive MRI probe based on Gd(iii)-nicotinamide by Harris, Michael, Kolanowski, Jacek L, O'Neill, Edward S, Henoumont, Céline, Laurent, Sophie, Parac-Vogt, Tatjana N, New, Elizabeth J

“…A novel, reversible redox-active MRI probe, GdNR1, has been developed for the study of redox changes associated with diseased states. This system exhibits…”
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The Combined Use of High Pressure Processing and Lactic Acid Containing Fermentate on Inactivation of Salmonella, Shiga Toxin-producing E. coli, and Listeria monocytogenes in Raw Pet Foods by Lee, Alvin, Maks-Warren, Nicole, Aguilar, Viviana, Swicegood, Brittany, Halik, Lindsay, Warren, Joshua, O’Neill, Edward, Meents, Jason, Tejayadi, Susy

“…•HPP with the addition of LAF enhances pathogen reduction.•LAF may change the relative HPP resistance of pathogens.•Salmonella had >5 log inactivation at 1%…”
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[ 123 I]CC1: A PARP-Targeting, Auger Electron-Emitting Radiopharmaceutical for Radionuclide Therapy of Cancer by Chan, Chung Ying, Chen, Zijun, Guibbal, Florian, Dias, Gemma, Destro, Gianluca, O'Neill, Edward, Veal, Mathew, Lau, Doreen, Mosley, Michael, Wilson, Thomas C, Gouverneur, Véronique, Cornelissen, Bart

“…Poly(adenosine diphosphate ribose) polymerase (PARP) has emerged as an effective therapeutic strategy against cancer that targets the DNA damage repair enzyme…”
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Imaging PARP with [18F]rucaparib in pancreatic cancer models by Chan, Chung Ying, Chen, Zijun, Destro, Gianluca, Veal, Mathew, Lau, Doreen, O’Neill, Edward, Dias, Gemma, Mosley, Michael, Kersemans, Veerle, Guibbal, Florian, Gouverneur, Véronique, Cornelissen, Bart

“…Purpose Rucaparib, an FDA-approved PARP inhibitor, is used as a single agent in maintenance therapy to provide promising treatment efficacy with an acceptable…”
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Pulmonary cryptococcosis complicating interstitial lung disease in a patient with systemic lupus erythematosus by Gaiba, Rahul, O’Neill, Edward, Lakshmi, Seetha

“…We report a case of primary pulmonary cryptococcosis in a 59-year-old female patient with a history of systemic lupus erythematosus, interstitial lung disease…”
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Extending the LRM Model to Integrating Resources by Aalberg, Trond, O'Neill, Edward, Žumer, Maja

“…Integrating resources are distinct in that they change over time in such a way that their previous content is replaced with updated content. This study…”
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A randomized clinical trial of the efficacy and safety of sitagliptin compared with dapagliflozin in patients with type 2 diabetes mellitus and mild renal insufficiency: The CompoSIT‐R study by Scott, Russell, Morgan, Jerry, Zimmer, Zachary, Lam, Raymond L. H., O'Neill, Edward A., Kaufman, Keith D., Engel, Samuel S., Raji, Annaswamy

“…Aim To compare the efficacy and safety of the dipeptidyl peptidase‐4 inhibitor sitagliptin with the sodium‐glucose transporter‐2 inhibitor dapagliflozin in…”
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The effect of cranberry consumption on lipid metabolism and inflammation in human apo A-I transgenic mice fed a high-fat and high-cholesterol diet by Caceres, Christian, Kim, Mi-Bo, Bae, Minkyung, Pham, Tho X., Lee, Yoojin, Hu, Siqi, O’Neill, Edward N., Kim, Bohkyung, Park, Young-Ki, Lee, Ji-Young

“…Lipid metabolism and inflammation contribute to CVD development. This study investigated whether the consumption of cranberries (CR; Vaccinium macrocarpon) can…”
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Double‐blind, randomized clinical trial comparing the efficacy and safety of continuing or discontinuing the dipeptidyl peptidase‐4 inhibitor sitagliptin when initiating insulin glargine therapy in patients with type 2 diabetes: The CompoSIT‐I Study by Roussel, Ronan, Duran‐García, Santiago, Zhang, Yilong, Shah, Suneri, Darmiento, Carolyn, Shankar, R. Ravi, Golm, Gregory T., Lam, Raymond L. H., O'Neill, Edward A., Gantz, Ira, Kaufman, Keith D., Engel, Samuel S.

“…Aims To compare the effects of continuing versus discontinuing sitagliptin when initiating and intensively titrating insulin glargine. Materials and methods…”
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Single‐ and Multiple‐Dose Pharmacokinetics of Gefapixant (MK‐7264), a P2X3 Receptor Antagonist, in Healthy Adults by Nussbaum, Jesse C., Hussain, Azher, Butera, Peter, Ford, Anthony P., Kitt, Michael M., O'Neill, Edward A., Smith, Steven, Vargas, Gabriel, O'Reilly, Terry, Wynne, Chris, Stoch, S. Aubrey, Iwamoto, Marian

“…Gefapixant (MK‐7264, RO4926219, AF‐219) is a first‐in‐class P2X3 antagonists being developed to treat refractory or unexplained chronic cough. The initial…”
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Inactivation of Salmonella, Shiga Toxin-producing E. coli, and Listeria monocytogenes in Raw Diet Pet Foods Using High-Pressure Processing by Lee, Alvin, Maks-Warren, Nicole, Aguilar, Viviana, Piszczor, Karolina, Swicegood, Brittany, Ye, Mu, Warren, Joshua, O'Neill, Edward, Fleck, Mark, Tejayadi, Susy

“…•Formulation and protein type impacted pathogen reduction at 586 MPa for 1–4 min.•Frozen storage maintained pathogen reduction better than refrigerated…”
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