Exercise training and nutritional supplementation for physical frailty in very elderly people

Background. Although disuse of skeletal muscle and undernutrition are often cited as potentially reversible causes of frailty in elderly people, the efficacy of interventions targeted specifically at these deficits has not been carefully studied. Methods. We conducted a randomized, placebo-controlle...

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Published in:	The New England journal of medicine Vol. 330; no. 25; pp. 1769 - 1775
Main Authors:	Fiatarone, M.A, O'Neill, E.F, Ryan, N.D, Clements, K.M, Solares, G.R, Nelson, M.E, Roberts, S.B, Kehayias, J.J, Lipsitz, L.A, Evans, W.J
Format:	Journal Article
Language:	English
Published:	Boston, MA Massachusetts Medical Society 23-06-1994
Subjects:	ACTIVIDAD FISICA ACTIVITE PHYSIQUE Age Aged Aged, 80 and over Aging Biological and medical sciences Body Composition Chronic illnesses COMPLEMENT ALIMENTAIRE Dietary supplements EFECTOS SECUNDARIOS EFFET SECONDAIRE Energy Energy Intake ESTADO NUTRICIONAL ETAT NUTRITIONNEL Exercise Exercise Therapy Female FEMME Fitness training programs Food, Fortified Frail Elderly Frailty Gait Geriatrics HOMBRES HOMME Humans Hypertension Male MASSACHUSETTS Medical research Medical sciences Metabolic diseases MOUVEMENT MOVIMIENTO MUJERES Muscle function Muscle strength Muscles - physiology NUTRICION HUMANA Nutrition NUTRITION HUMAINE Nutrition research Nutritional Status Older people Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...) PERSONNE AGEE Physical activity Physical Endurance Physical fitness Physical training Rehabilitation RESISTANCE MECANIQUE RESISTENCIA MECANICA Skeletal muscle Strength training SUPLEMENTOS TERCERA EDAD Undernutrition Human Physical exercise Treatment Malnutrition Elderly Feeding
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Summary:	Background. Although disuse of skeletal muscle and undernutrition are often cited as potentially reversible causes of frailty in elderly people, the efficacy of interventions targeted specifically at these deficits has not been carefully studied. Methods. We conducted a randomized, placebo-controlled trial comparing progressive resistance exercise training, multinutrient supplementation, both interventions, and neither in 100 frail nursing home residents over a 10-week period. Results. The mean (+/- SE) age of the 63 women and 37 men enrolled in the study was 87.1 +/- 0.6 years (range, 72 to 98); 94 percent of the subjects completed the study. Muscle strength increased by 113 +/- 8 percent in the subjects who underwent exercise training, as compared with 3 +/- 9 percent in the nonexercising subjects (P 0.001). Gait velocity increased by 11.8 +/- 3.8 percent in the exercisers but declined by 1.0 +/- 3.8 percent in the nonexercisers (P
Bibliography:	S30 9515507 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-News-3 content type line 23
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJM199406233302501