Search Results - "O'Neill, CA"

Effects of Aerosol from Biomass Burning on the Global Radiation Budget by Penner, Joyce E., Dickinson, Robert E., O'Neill, Christine A.

“…An analysis is made of the likely contribution of smoke particles from biomass burning to the global radiation balance. These particles act to reflect solar…”
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Altered claudin expression is a feature of chronic plaque psoriasis by Watson, REB, Poddar, R, Walker, JM, McGuill, I, Hoare, LM, Griffiths, CEM, O'Neill, CA

“…Epithelial tight junctions play a central role in cell–cell adhesion and are necessary for the selective paracellular movement of ions. Claudins are key…”
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Reactive oxygen species and the lung by Cross, C E, van der Vliet, A, O'Neill, C A, Eiserich, J P

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Cigarette smoke oxidation of human plasma constituents by Cross, C E, O'Neill, C A, Reznick, A Z, Hu, M L, Marcocci, L, Packer, L, Frei, B

“…In vitro exposure of fresh human plasma to cigarette smoke (CS) was used as a model for reactions that could be occurring in CS-exposed respiratory tract…”
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Molecular mechanisms of damage by excess nitrogen oxides: Nitration of tyrosine by gas-phase cigarette smoke by Eiserich, Jason, Vossen, Veronique, O'Neill, Charles A., Halliwell, Barry, Cross, Carroll E., van der Vliet, Albert

“…Nitric oxide (nitrogen monoxide, •NO) plays important physiological roles, but an excess can be toxic. •NO is present in cigarette smoke (CS) at up to 500 ppm,…”
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Organic osmolytes increase expression of specific tight junction proteins in skin and alter barrier function in keratinocytes by El‐Chami, C., Foster, A.R., Johnson, C., Clausen, R.P., Cornwell, P., Haslam, I.S., Steward, M.C., Watson, R.E.B., Young, H.S., O'Neill, C.A.

“…Summary Background The epidermal barrier is important for water conservation, failure of which is evident in dry‐skin conditions. Barrier function is fulfilled…”
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Differential expression and functionality of ATP-binding cassette transporters in the human hair follicle by Haslam, I.S., El-Chami, C., Faruqi, H., Shahmalak, A., O'Neill, C.A., Paus, R.

“…Summary Background ATP‐binding cassette (ABC) transporters are involved in the active transport of an extremely diverse range of substrates across biological…”
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Molecular analysis of PKU in Ireland by O'Neill, C A, Eisensmith, R C, Croke, D T, Naughten, E R, Cahalane, S F, Woo, S L

“…Classical phenylketonuria (PKU: McKusick No. 261600) is caused by mutations occurring at the phenylalanine hydroxylase (PAH) locus on chromosome 12 and has a…”
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Biochemical mechanisms for the attenuation of bleomycin-induced lung fibrosis by treatment with niacin in hamsters: the role of NAD and ATP by O'Neill, C A, Giri, S N

“…Treatment with niacin (NA), a precursor of NAD, has been shown to attenuate collagen accumulation in the bleomycin (BL) hamster model of lung fibrosis. This…”
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Ochratoxin A increases permeability through tight junctions by removal of specific claudin isoforms by McLaughlin, John, Padfield, Philip J, Burt, Julian P H, O'Neill, Catherine A

“…On interaction with the intestine, the mycotoxin ochratoxin A is know to cause rapid inflammation, diarrhea, and increased bacterial translocation. All these…”
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Depletion of Caco-2 cell cholesterol disrupts barrier function by altering the detergent solubility and distribution of specific tight-junction proteins by Lambert, Daniel, O'Neill, Catherine A, Padfield, Philip J

“…In the present study, we have investigated the role of cholesterol in maintaining the barrier properties of the model intestinal cell line Caco-2. We have…”
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Ochratoxin A displaces claudins from detergent resistant membrane microdomains by Lambert, Daniel, Padfield, Philip J., McLaughlin, John, Cannell, Stephanie, O’Neill, Catherine A.

“…Ochratoxin A (OchA) is a food-borne mycotoxin with multiple effects in vivo. Previously, we have demonstrated that the toxin can significantly impair the…”
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The mycotoxin patulin, modulates tight junctions in caco-2 cells by McLaughlin, John, Lambert, Daniel, Padfield, Philip J., Burt, Julian P.H., O’Neill, Catherine A.

“…The mycotoxin patulin is a common contaminant of fruit. Here, we demonstrate that patulin reduces the barrier properties of the intestinal cell line, caco-2 by…”
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Kinetic profiling of P-glycoprotein-mediated drug efflux in rat and human intestinal epithelia by Stephens, R H, O'Neill, C A, Warhurst, A, Carlson, G L, Rowland, M, Warhurst, G

“…Intestinal drug efflux mediated by P-glycoprotein and other ABC transporters is widely accepted as a reason for low or variable oral absorption. However,…”
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Effect of Intravitreal Injection of Ranibizumab in Combination with Verteporfin PDT on Normal Primate Retina and Choroid by Kim, Ivana K, Husain, Deeba, Michaud, Norman, Connolly, Edward, Lane, Anne Marie, Durrani, Khayyam, Hafezi-Moghadam, Ali, Gragoudas, Evangelos S, O'Neill, Charles A, Beyer, Joseph C, Miller, Joan W

“…To evaluate the effect of intravitreal injection of a monoclonal antibody fragment (ranibizumab, also known as rhuFab V2 and Lucentis; Genentech, S. San…”
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Determination of low-molecular-mass antioxidant concentrations in human respiratory tract lining fluids by van der Vliet, A, O'Neill, C A, Cross, C E, Koostra, J M, Volz, W G, Halliwell, B, Louie, S

“…Antioxidants present within lung epithelial lining fluids (ELFs) constitute an initial line of defense against inhaled environmental oxidants such as ozone,…”
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PP4.5 – 1813 Nonclinical development of rhTPP1 enzyme replacement therapy for NCL2 by Vuillemenot, BR, Kennedy, D, Katz, ML, Coates, JR, Lobel, P, Tsuruda, LS, Henshaw, J, Musson, D, Keve, S, Cahayag, R, Tiger, P, O'Neill, CA

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Resolution of P‐glycoprotein and non‐P‐glycoprotein effects on drug permeability using intestinal tissues from mdr1a (−/−) mice by Stephens, R H, O'Neill, C A, Bennett, J, Humphrey, M, Henry, B, Rowland, M, Warhurst, G

“…Intestinal xenobiotic transporters are a significant barrier to the absorption of many orally administered drugs. P‐glycoprotein (PGP) is the best known, but…”
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Preclinical Safety Evaluation of rhuMAbVEGF, an Antiangiogenic Humanized Monoclonal Antibody by Ryan, Anne M., Eppler, Dorothy Bates, Hagler, Kelly E., Bruner, Richard H., Thomford, Peter J., Hall, Robert L., Shopp, George M., O'Neill, Charles A.

“…Recombinant humanized antivascular endothelial growth factor (rhuMAbVEGF) is a monoclonal IgG, antibody that is being developed as an antiangiogenic agent for…”
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Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment by Krzystolik, Magdalena G, Afshari, Mehran A, Adamis, Anthony P, Gaudreault, Jacques, Gragoudas, Evangelos S, Michaud, Norman A, Li, Wenjun, Connolly, Edward, O'Neill, Charles A, Miller, Joan W

“…To evaluate the safety and efficacy of intravitreal injections of an antigen-binding fragment of a recombinant humanized monoclonal antibody directed toward…”
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