Search Results - "O'Neill, A"

Metabolic reprogramming in macrophages and dendritic cells in innate immunity by Kelly, Beth, O'Neill, Luke AJ

“…Activation of macrophages and dendritic cells （DCs） by pro-inflammatory stimuli causes them to undergo a metabolic switch towards glycolysis and away from…”
Get full text

Reprogramming mitochondrial metabolism in macrophages as an anti‐inflammatory signal by Mills, Evanna L., O'Neill, Luke A.

“…Mitochondria are master regulators of metabolism. Mitochondria generate ATP by oxidative phosphorylation using pyruvate (derived from glucose and glycolysis)…”
Get full text

Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming by Olagnier, David, Brandtoft, Aske M., Gunderstofte, Camilla, Villadsen, Nikolaj L., Krapp, Christian, Thielke, Anne L., Laustsen, Anders, Peri, Suraj, Hansen, Anne Louise, Bonefeld, Lene, Thyrsted, Jacob, Bruun, Victor, Iversen, Marie B., Lin, Lin, Artegoitia, Virginia M., Su, Chenhe, Yang, Long, Lin, Rongtuan, Balachandran, Siddharth, Luo, Yonglun, Nyegaard, Mette, Marrero, Bernadette, Goldbach-Mansky, Raphaela, Motwani, Mona, Ryan, Dylan G., Fitzgerald, Katherine A., O’Neill, Luke A., Hollensen, Anne K., Damgaard, Christian K., de Paoli, Frank v., Bertram, Hanne C., Jakobsen, Martin R., Poulsen, Thomas B., Holm, Christian K.

“…The transcription factor Nrf2 is a critical regulator of inflammatory responses. If and how Nrf2 also affects cytosolic nucleic acid sensing is currently…”
Get full text

The history of Toll-like receptors — redefining innate immunity by O'Neill, Luke A. J., Golenbock, Douglas, Bowie, Andrew G.

“…The past 15 years have seen a breakthrough in the field of innate immunity. In this Timeline article, the authors discuss the early events that led to the…”
Get full text

Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome by Neudecker, Viola, Haneklaus, Moritz, Jensen, Owen, Khailova, Ludmila, Masterson, Joanne C, Tye, Hazel, Biette, Kathryn, Jedlicka, Paul, Brodsky, Kelley S, Gerich, Mark E, Mack, Matthias, Robertson, Avril A B, Cooper, Matthew A, Furuta, Glenn T, Dinarello, Charles A, O'Neill, Luke A, Eltzschig, Holger K, Masters, Seth L, McNamee, Eóin N

“…MicroRNA (miRNA)-mediated RNA interference regulates many immune processes, but how miRNA circuits orchestrate aberrant intestinal inflammation during…”
Get full text

NLRP3 at the interface of metabolism and inflammation by Haneklaus, Moritz, O'Neill, Luke A. J.

“…Summary The discovery of the NLRP3 (NLR family, pyrin domain containing 3) inflammasome provided an important molecular mechanism in the induction of the…”
Get full text

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages by Mills, Evanna L., Kelly, Beth, Logan, Angela, Costa, Ana S.H., Varma, Mukund, Bryant, Clare E., Tourlomousis, Panagiotis, Däbritz, J. Henry M., Gottlieb, Eyal, Latorre, Isabel, Corr, Sinéad C., McManus, Gavin, Ryan, Dylan, Jacobs, Howard T., Szibor, Marten, Xavier, Ramnik J., Braun, Thomas, Frezza, Christian, Murphy, Michael P., O’Neill, Luke A.

“…Activated macrophages undergo metabolic reprogramming, which drives their pro-inflammatory phenotype, but the mechanistic basis for this remains obscure. Here,…”
Get full text

An Overview of Interrater Agreement on Likert Scales for Researchers and Practitioners by O'Neill, Thomas A

“…Applications of interrater agreement (IRA) statistics for Likert scales are plentiful in research and practice. IRA may be implicated in job analysis,…”
Get full text

The Immunomodulatory Potential of the Metabolite Itaconate by Hooftman, Alexander, O’Neill, Luke A.J.

“…The field of immunometabolism has demonstrated that metabolites can lead double lives as immunomodulators. Itaconate is perhaps the best example of such a…”
Get full text

Monitoring cognitive functioning in MS will trigger anxiety in patients: Yes by Krupp, Lauren, O’Neill, Kimberly A

Get full text

Plant Nucleotide Sugar Formation, Interconversion, and Salvage by Sugar Recycling by Bar-Peled, Maor, O'Neill, Malcolm A

“…Nucleotide sugars are the universal sugar donors for the formation of polysaccharides, glycoproteins, proteoglycans, glycolipids, and glycosylated secondary…”
Get full text

A Broken Krebs Cycle in Macrophages by O’Neill, Luke A.J.

“…Macrophages undergo metabolic rewiring during polarization but details of this process are unclear. In this issue of Immunity, Jha et al. (2015) report a…”
Get full text

Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity by Arts, Rob J.W., Novakovic, Boris, ter Horst, Rob, Carvalho, Agostinho, Bekkering, Siroon, Lachmandas, Ekta, Rodrigues, Fernando, Silvestre, Ricardo, Cheng, Shih-Chin, Wang, Shuang-Yin, Habibi, Ehsan, Gonçalves, Luís G., Mesquita, Inês, Cunha, Cristina, van Laarhoven, Arjan, van de Veerdonk, Frank L., Williams, David L., van der Meer, Jos W.M., Logie, Colin, O'Neill, Luke A., Dinarello, Charles A., Riksen, Niels P., van Crevel, Reinout, Clish, Clary, Notebaart, Richard A., Joosten, Leo A.B., Stunnenberg, Hendrik G., Xavier, Ramnik J., Netea, Mihai G.

“…Induction of trained immunity (innate immune memory) is mediated by activation of immune and metabolic pathways that result in epigenetic rewiring of cellular…”
Get full text

Metabolism of inflammation limited by AMPK and pseudo-starvation by O'Neill, Luke A. J., Hardie, D. Grahame

“…Metabolic changes in cells that participate in inflammation, such as activated macrophages and T-helper 17 cells, include a shift towards enhanced glucose…”
Get full text

The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype by Basiorka, Ashley A., McGraw, Kathy L., Eksioglu, Erika A., Chen, Xianghong, Johnson, Joseph, Zhang, Ling, Zhang, Qing, Irvine, Brittany A., Cluzeau, Thomas, Sallman, David A., Padron, Eric, Komrokji, Rami, Sokol, Lubomir, Coll, Rebecca C., Robertson, Avril A.B., Cooper, Matthew A., Cleveland, John L., O'Neill, Luke A., Wei, Sheng, List, Alan F.

“…Despite genetic heterogeneity, myelodysplastic syndromes (MDSs) share features of cytological dysplasia and ineffective hematopoiesis. We report that a…”
Get full text

A trio of microRNAs that control Toll-like receptor signalling by Quinn, Susan R., O'Neill, Luke A.

“…Toll-like receptors (TLRs) in the host recognize conserved microbial products and defend against pathogenic attack by initiating an immune response via…”
Get full text

Optimised protocol for monitoring SARS-CoV-2 in wastewater using reverse complement PCR-based whole-genome sequencing by Child, Harry T, O'Neill, Paul A, Moore, Karen, Rowe, William, Denise, Hubert, Bass, David, Wade, Matthew J, Loose, Matt, Paterson, Steve, van Aerle, Ronny, Jeffries, Aaron R

“…Monitoring the spread of viral pathogens in the population during epidemics is crucial for mounting an effective public health response. Understanding the…”
Get full text

What's Love Got to Do with It? A Longitudinal Study of the Culture of Companionate Love and Employee and Client Outcomes in a Long-term Care Setting by Barsade, Sigal G., O'Neill, Olivia A.

“…In this longitudinal study, we build a theory of a culture of companionate love—feelings of affection, compassion, caring, and tenderness for others—at work,…”
Get full text

interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress by O'Neill, Luke A.J

“…The interleukin-1 receptor (IL-1R)/Toll-like receptor (TLR) superfamily was first defined in 1998 as a family of proteins that contain the Toll-IL-1 receptor…”
Get full text

Placing Forestry in the Assisted Migration Debate by Pedlar, John H, McKenney, Daniel W, Aubin, Isabelle, Beardmore, Tannis, Beaulieu, Jean, Iverson, Louis, O'Neill, Gregory A, Winder, Richard S, Ste-Marie, Catherine

“…Assisted migration (AM) id often presented as a strategy to save species that are imminently threatened by rapid climate change. This conception of AM, which…”
Get full text