Search Results - "O'Neil, Shawn P"

Tofacitinib attenuates pathologic immune pathways in patients with psoriasis: A randomized phase 2 study by Krueger, James, MD, PhD, Clark, James D., PhD, Suárez-Fariñas, Mayte, PhD, Fuentes-Duculan, Judilyn, MD, Cueto, Inna, MSc, Wang, Claire Q., PhD, Tan, Huaming, PhD, Wolk, Robert, MD, Rottinghaus, Scott T., MD, Whitley, Maryann Z., DSc, Valdez, Hernan, MD, von Schack, David, PhD, O'Neil, Shawn P., DVM, PhD, Reddy, Padmalatha S., PhD, Tatulych, Svitlana, MD

“…Background Tofacitinib is an oral Janus kinase inhibitor being investigated for psoriasis. Objective We sought to elucidate the molecular mechanisms underlying…”
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Evolution of a TRIM5-CypA splice isoform in old world monkeys by Newman, Ruchi M, Hall, Laura, Kirmaier, Andrea, Pozzi, Lu-Ann, Pery, Erez, Farzan, Michael, O'Neil, Shawn P, Johnson, Welkin

“…The TRIM family proteins share a conserved arrangement of three adjacent domains, an N-terminal RING domain, followed by one or two B-boxes and a coiled-coil,…”
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Nonpathogenic SIV Infection of Sooty Mangabeys Is Characterized by Limited Bystander Immunopathology Despite Chronic High-Level Viremia by Silvestri, Guido, Sodora, Donald L., Koup, Richard A., Paiardini, Mirko, O'Neil, Shawn P., McClure, Harold M., Staprans, Silvija I., Feinberg, Mark B.

“…HIV-infected humans and SIV-infected rhesus macaques who remain healthy despite long-term infection exhibit exceptionally low levels of virus replication and…”
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An orthogonal methods assessment of topical drug concentrations in skin and the impact for risk assessment in the viable epidermis by Hollingshead, Brett D., Tomlinson, Lindsay, Finley, Jim, Doshna, Colleen, Ritenour, Casey, Barricklow, Jason, Oppenheimer, Stacey R., O'Neil, Shawn P., Moore, Jessica L., Patterson, Nathan Heath, Nicholson, Sarah P., Norris, Jeremy L., Caprioli, Richard M., Beaumont, Kevin, King-Ahmad, Amanda J., Vispute, Saurabh, Cook, Jon C., Radi, Zaher, Schuler, Maik

“…Systemic toxicity assessments for oral or parenteral drugs often utilize the concentration of drug in plasma to enable safety margin calculations for human…”
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Diffusion tensor imaging detects treatment effects of FTY720 in experimental autoimmune encephalomyelitis mice by Wang, Xiaojie, Brieland, Joan K., Kim, Joong H., Chen, Ying-Jr, O'Neal, Janet, O'Neil, Shawn P., Tu, Tsang-Wei, Trinkaus, Kathryn, Song, Sheng-Kwei

“…Fingolimod (FTY720) is an orally available sphingosine‐1‐phosphate (S1P) receptor modulator reducing relapse frequency in patients with relapsing–remitting…”
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Relative Transmissibility of an R5 Clade C Simian- Human Immunodeficiency Virus Across Different Mucosae in Macaques Parallels the Relative Risks of Sexual HIV-1 Transmission in Humans via Different Routes by Chenine, Agnès L., Siddappa, Nagadenahalli B., Kramer, Victor G., Sciaranghella, Gaia, Rasmussen, Robert A., Lee, Sandra J., Santosuosso, Michael, Poznansky, Mark C., Velu, Vijayakumar, Amara, Rama R., Souder, Chris, Anderson, Daniel C., Villinger, François, Else, James G., Novembre, Francis J., Strobert, Elizabeth, O'Neil, Shawn P., Secor, W. Evan, Ruprecht, Ruth M.

“…Background. Worldwide, ∼90% of all human immunodeficiency virus (HIV) transmissions occur mucosally; almost all involve R5 strains. Risks of sexual HIV…”
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SHIV-1157i and passaged progeny viruses encoding R5 HIV-1 clade C env cause AIDS in rhesus monkeys by Humbert, Michael, Rasmussen, Robert A, Song, Ruijiang, Ong, Helena, Sharma, Prachi, Chenine, Agnès L, Kramer, Victor G, Siddappa, Nagadenahalli B, Xu, Weidong, Else, James G, Novembre, Francis J, Strobert, Elizabeth, O'Neil, Shawn P, Ruprecht, Ruth M

“…Infection of nonhuman primates with simian immunodeficiency virus (SIV) or chimeric simian-human immunodeficiency virus (SHIV) strains is widely used to study…”
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Probable Deceleration of Progression of Simian AIDS Affected by Opiate Dependency: Studies With a Rhesus Macaque/SIVsmm9 Model by Donahoe, Robert M, OʼNeil, Shawn P, Marsteller, Frederick A, Novembre, Francis J, Anderson, Daniel C, Lankford-Turner, Pamela, McClure, Harold H

“…OBJECTIVES:To determine effects of opiate dependency on development of simian AIDS. DESIGN:Assessments of viral, immune, and clinicopathological status were…”
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Myocarditis in CD8-depleted SIV-infected rhesus macaques after short-term dual therapy with nucleoside and nucleotide reverse transcriptase inhibitors by Annamalai, Lakshmanan, Westmoreland, Susan V, Domingues, Heber G, Walsh, Dennis G, Gonzalez, R Gilberto, O'Neil, Shawn P

“…Although highly active antiretroviral therapy (HAART) has dramatically reduced the morbidity and mortality associated with HIV infection, a number of…”
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Critical Role for Env as well as Gag-Pol in Control of a Simian-Human Immunodeficiency Virus 89.6P Challenge by a DNA Prime/Recombinant Modified Vaccinia Virus Ankara Vaccine by Amara, Rama Rao, Smith, James M, Staprans, Silvija I, Montefiori, David C, Villinger, Francois, Altman, John D, O'Neil, Shawn P, Kozyr, Natalia L, Xu, Yan, Wyatt, Linda S, Earl, Patricia L, Herndon, James G, McNicholl, Janet M, McClure, Harold M, Moss, Bernard, Robinson, Harriet L

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Quantitative performance assessment of Ultivue multiplex panels in formalin-fixed, paraffin-embedded human and murine tumor specimens by Ram, Sripad, Mojtahedzadeh, Sepideh, Aguilar, Joan-Kristel, Coskran, Timothy, Powell, Eric L., O’Neil, Shawn P.

“…We present a rigorous validation strategy to evaluate the performance of Ultivue multiplex immunofluorescence panels. We have quantified the accuracy and…”
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Characterizing Intra-Tumor and Inter-Tumor Variability of Immune Cell Infiltrates in Murine Syngeneic Tumors by Mojtahedzadeh, Sepideh, Opsahl, Alan, Aguilar, Joan-Kristel, Li, Dingzhou, Streiner, Nicole, Wang, Jinwei, Trajkovic, Dusko, Boucher, Germaine, Coskran, Timothy, O'Neil, Shawn P., Ram, Sripad

“…Murine tumors are indispensable model systems in preclinical immuno-oncology research. While immunologic heterogeneity is well-known to be an important factor…”
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Acute Lymphoid and Gastrointestinal Toxicity Induced by Selective p38α Map Kinase and Map Kinase–Activated Protein Kinase-2 (MK2) Inhibitors in the Dog by Morris, Dale L., O’Neil, Shawn P., Devraj, Rajesh V., Portanova, Joseph P., Gilles, Richard W., Gross, Cindy J., Curtiss, Sandra W., Komocsar, Wendy J., Garner, Debra S., Happa, Fernando A., Kraus, Lori J., Nikula, Kristen J., Monahan, Joseph B., Selness, Shaun R., Galluppi, Gerald R., Shevlin, Kimberly M., Kramer, Jeffrey A., Walker, John K., Messing, Dean M., Anderson, David R., Mourey, Robert J., Whiteley, Laurence O., Daniels, John S., Yang, Jerry Z., Rowlands, Philip C., Alden, Carl L., Davis, John W., Sagartz, John E.

“…Exposure to moderately selective p38α mitogen-activated protein kinase (MAPK) inhibitors in the Beagle dog results in an acute toxicity consisting of mild…”
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Identification of tubular injury microRNA biomarkers in urine: comparison of next-generation sequencing and qPCR-based profiling platforms by Nassirpour, Rounak, Mathur, Sachin, Gosink, Mark M, Li, Yizheng, Shoieb, Ahmed M, Wood, Joanna, O'Neil, Shawn P, Homer, Bruce L, Whiteley, Laurence O

“…MicroRNAs (miRNAs) are small, non-coding RNAs that regulate protein levels post-transcriptionally. miRNAs play important regulatory roles in many cellular…”
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Comparative nonclinical assessments of the biosimilar PF-06410293 and originator adalimumab by Derzi, Mazin, Shoieb, Ahmed M., Ripp, Sharon L., Finch, Gregory L., Lorello, Leslie G., O'Neil, Shawn P., Radi, Zaher, Syed, Jameel, Thompson, Matthew S., Leach, Michael W.

“…Adalimumab, a recombinant fully human monoclonal antibody targeting tumor necrosis factor (TNF), is approved in the United States and Europe to treat various…”
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Soluble Fn14 Is Detected and Elevated in Mouse and Human Kidney Disease by Sharif, M Nusrat, Campanholle, Gabriela, Nagiec, Eva E, Wang, Ju, Syed, Jameel, O'Neil, Shawn P, Zhan, Yutian, Brenneman, Karrie, Homer, Bruce, Neubert, Hendrik, Karim, Riyez, Pullen, Nick, Evans, Steven M, Fleming, Margaret, Chockalingam, Priya, Lin, Lih-Ling

“…The cytokine TWEAK and its cognate receptor Fn14 are members of the TNF/TNFR superfamily and are upregulated in tissue injury to mediate local tissue responses…”
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Identification of Promising Urinary MicroRNA Biomarkers in Two Rat Models of Glomerular Injury by Nassirpour, Rounak, Homer, Bruce L, Mathur, Sachin, Li, Yizheng, Li, Zhonghan, Brown, Tom, Carraher, Deborah, Warneke, James, Bailey, Steven, Percival, Karen, O'Neil, Shawn P, Whiteley, Laurence O

“…MicroRNAs (miRNAs) are small, noncoding RNAs that regulate protein levels posttranscriptionally. miRNAs play important regulatory roles in many cellular…”
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Quantitative biodistribution of biotherapeutics at whole body, organ and cellular levels by autoradiography by Wang, Mengmeng, Zhan, Yutian, O'Neil, Shawn P, Harris, Stephen, Henson, Claire, McEwen, Andrew, Webster, Rob, O'Hara, Denise M

“…Tools for mapping and quantifying monoclonal antibody (mAb) and peptide biotherapeutics distribumtion were evaluated by comparing data from three independent…”
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Progressive Infection in a Subset of HIV-1—Positive Chimpanzees by O'Neil, Shawn P., Novembre, Francis J., Hill, Anne Brodie, Suwyn, Carolyn, Hart, Clyde E., Evans-Strickfaden, Tammy, Anderson, Daniel C., deRosayro, Juliette, Herndon, James G., Saucier, Michelle, McClure, Harold M.

“…Chimpanzees are susceptible to infection with human immunodeficiency virus (HIV)—1; however, infected animals usually maintain normal numbers of CD4+ T…”
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Control of a Mucosal Challenge and Prevention of AIDS by a Multiprotein DNA/MVA Vaccine by Amara, Rama Rao, Villinger, Francois, Altman, John D., Lydy, Shari L., O'Neil, Shawn P., Staprans, Silvija I., Montefiori, David C., Xu, Yan, Herndon, James G., Wyatt, Linda S., Candido, Maria Angelito, Kozyr, Natalia L., Earl, Patricia L., Smith, James M., Ma, Hak-Ling, Grimm, Bennett D., Hulsey, Michael L., Miller, Joseph, McClure, Harold M., McNicholl, Janet M., Moss, Bernard, Robinson, Harriet L.

“…Heterologous prime/boost regimens have the potential for raising high levels of immune responses. Here we report that DNA priming followed by a recombinant…”
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