Search Results - "O'Neil, John D."

Tissue-specific roles for sonic hedgehog signaling in establishing thymus and parathyroid organ fate by Bain, Virginia E, Gordon, Julie, O'Neil, John D, Ramos, Isaias, Richie, Ellen R, Manley, Nancy R

“…The thymus and parathyroids develop from third pharyngeal pouch (3rd pp) endoderm. Our previous studies show that Shh null mice have smaller, aparathyroid…”
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Managing Matajoosh: determinants of first Nations' cancer care decisions by Lavoie, Josée G, Kaufert, Joseph, Browne, Annette J, O'Neil, John D

“…Accessing cancer treatment requires First Nation peoples living in rural and remote communities to either commute to care, or to relocate to an urban centre…”
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Have investments in on-reserve health services and initiatives promoting community control improved First Nations’ health in Manitoba? by Lavoie, Josée Gabrielle, Forget, Evelyn L., Prakash, Tara, Dahl, Matt, Martens, Patricia, O’Neil, John D.

“…The objective of this study was to document the relationship between First Nation’s community characteristics and the rates of hospitalization for Ambulatory…”
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Functional Astrocyte-Neuron Lactate Shuttle in a Human Stem Cell-Derived Neuronal Network by Tarczyluk, Marta A, Nagel, David A, O’Neil, John D, Parri, H Rheinallt, Tse, Erin HY, Coleman, Michael D, Hill, Eric J

“…The NT2.D1 cell line is one of the most well-documented embryocarcinoma cell lines, and can be differentiated into neurons and astrocytes. Great focus has also…”
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A preliminary investigation into the impact of a pesticide combination on human neuronal and glial cell lines in vitro by Coleman, Michael D, O'Neil, John D, Woehrling, Elizabeth K, Ndunge, Oscar Bate Akide, Hill, Eric J, Menache, Andre, Reiss, Claude J

“…Many pesticides are used increasingly in combinations during crop protection and their stability ensures the presence of such combinations in foodstuffs. The…”
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Epstein-Barr virus-encoded EBNA1 modulates the AP-1 transcription factor pathway in nasopharyngeal carcinoma cells and enhances angiogenesis in vitro by O'Neil, John D, Owen, Thomas J, Wood, Victoria H. J, Date, Kathryn L, Valentine, Robert, Chukwuma, Marilyn B, Arrand, John R, Dawson, Christopher W, Young, Lawrence S

“…Cancer Research UK Institute for Cancer Studies, University of Birmingham, Vincent Drive, Edgbaston, Birmingham B15 2TT, UK Correspondence John D. O'Neil…”
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Epstein-Barr virus-encoded EBNA1 inhibits the canonical NF-κB pathway in carcinoma cells by inhibiting IKK phosphorylation by Valentine, Robert, Dawson, Christopher W, Hu, Chunfang, Shah, Khilan M, Owen, Thomas J, Date, Kathryn L, Maia, Sonia P, Shao, Jianyong, Arrand, John R, Young, Lawrence S, O'Neil, John D

“…Abstract Background The Epstein-Barr virus (EBV)-encoded EBNA1 protein is expressed in all EBV-associated tumours, including undifferentiated nasopharyngeal…”
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Macrophage responses to lipopolysaccharide are modulated by a feedback loop involving prostaglandin E2, dual specificity phosphatase 1 and tristetraprolin by Tang, Tina, Scambler, Thomas E., Smallie, Tim, Cunliffe, Helen E., Ross, Ewan A., Rosner, Dalya R., O’Neil, John D., Clark, Andrew R.

“…In many different cell types, pro-inflammatory agonists induce the expression of cyclooxygenase 2 (COX-2), an enzyme that catalyzes rate-limiting steps in the…”
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Priming in response to pro-inflammatory cytokines is a feature of adult synovial but not dermal fibroblasts by Crowley, Thomas, O'Neil, John D, Adams, Holly, Thomas, Andrew M, Filer, Andrew, Buckley, Christopher D, Clark, Andrew R

“…It has been hypothesized that chronic inflammatory diseases such as rheumatoid arthritis (RA) may be caused by a failure of negative feedback mechanisms. This…”
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Epstein-Barr virus-encoded EBNA1 enhances RNA polymerase III-dependent EBER expression through induction of EBER-associated cellular transcription factors by Owen, Thomas J, O'Neil, John D, Dawson, Christopher W, Hu, Chunfang, Chen, Xiaoyi, Yao, Yunhong, Wood, Victoria H J, Mitchell, Louise E, White, Robert J, Young, Lawrence S, Arrand, John R

“…Epstein-Barr Virus (EBV)-encoded RNAs (EBERs) are non-polyadenylated RNA molecules transcribed from the EBV genome by RNA polymerase III (pol III). EBERs are…”
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Identifying indigenous peoples for health research in a global context: a review of perspectives and challenges by Bartlett, Judith G., Madariaga-Vignudo, Lucia, O'Neil, John D., Kuhnlein, Harriet V.

“…Objectives. Identifying Indigenous Peoples globally is complex and contested despite there being an estimated 370 million living in 70 countries. The specific…”
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The RNA-binding protein Tristetraprolin (TTP) is a critical negative regulator of the NLRP3 inflammasome by Haneklaus, Moritz, O’Neil, John D., Clark, Andrew R., Masters, Seth L., O’Neill, Luke A.J.

“…The NLRP3 inflammasome is a central regulator of inflammation in many common diseases, including atherosclerosis and type 2 diabetes, driving the production of…”
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Fibroblasts Derived From Vestibular Schwannoma Express Protumorogenic Markers by Baruah, Paramita, Marshall, Jennifer, Jones, Philip N., Major, Triin, Pucino, Valentina, O'Neil, John D., Nefla, Meriam, McGettrick, Helen, Monksfield, Peter, Irving, Richard, Buckley, Christopher D.

“…Background and aim Vestibular schwannomas (VSs), despite being histologically benign, cause significant morbidity because of their challenging intracranial…”
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Dominant Suppression of Inflammation via Targeted Mutation of the mRNA Destabilizing Protein Tristetraprolin by Ross, Ewan A, Smallie, Tim, Ding, Qize, O'Neil, John D, Cunliffe, Helen E, Tang, Tina, Rosner, Dalya R, Klevernic, Iva, Morrice, Nicholas A, Monaco, Claudia, Cunningham, Adam F, Buckley, Christopher D, Saklatvala, Jeremy, Dean, Jonathan L, Clark, Andrew R

“…In myeloid cells, the mRNA-destabilizing protein tristetraprolin (TTP) is induced and extensively phosphorylated in response to LPS. To investigate the role of…”
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Underutilized and undertheorized: the use of hospitalization for ambulatory care sensitive conditions for assessing the extent to which primary healthcare services are meeting needs in British Columbia First Nation communities by Lavoie, Josée G, Wong, Sabrina T, Ibrahim, Naser, O'Neil, John D, Green, Michael, Ward, Amanda

“…Since the 1960s, the federal government has been providing or funding a selection of community-based primary healthcare (PHC) programs on First Nations…”
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Evaluation of full-length nanopore 16S sequencing for detection of pathogens in microbial keratitis by Low, Liying, Fuentes-Utrilla, Pablo, Hodson, James, O'Neil, John D, Rossiter, Amanda E, Begum, Ghazala, Suleiman, Kusy, Murray, Philip I, Wallace, Graham R, Loman, Nicholas J, Rauz, Saaeha

“…Microbial keratitis is a leading cause of preventable blindness worldwide. Conventional sampling and culture techniques are time-consuming, with over 40% of…”
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Dexamethasone impairs the expression of antimicrobial mediators in lipopolysaccharide-activated primary macrophages by inhibiting both expression and function of interferon β by O’Neil, John D., Bolimowska, Oliwia O., Clayton, Sally A., Tang, Tina, Daley, Kalbinder K., Lara-Reyna, Samuel, Warner, Jordan, Martin, Claire S., Mahida, Rahul Y., Hardy, Rowan S., Arthur, J. Simon C., Clark, Andrew R.

“…Glucocorticoids potently inhibit expression of many inflammatory mediators, and have been widely used to treat both acute and chronic inflammatory diseases for…”
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Hospitalization for mental health related ambulatory care sensitive conditions: what are the trends for First Nations in British Columbia? by Lavoie, Josée G, Ward, Amanda, Wong, Sabrina T, Ibrahim, Naser, Morton, Darrien, O'Neil, John D, Green, Michael

“…Indigenous peoples globally experience a disproportionate burden of mental illness due to forced policies and practices of colonization and cultural…”
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Effects of lithium and valproic acid on gene expression and phenotypic markers in an NT2 neurosphere model of neural development by Hill, Eric J, Nagel, David A, O'Neil, John D, Torr, Elizabeth, Woehrling, Elizabeth K, Devitt, Andrew, Coleman, Michael D

“…Mood stabilising drugs such as lithium (LiCl) and valproic acid (VPA) are the first line agents for treating conditions such as Bipolar disorder and Epilepsy…”
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Gain-of-Function Mutation of Tristetraprolin Impairs Negative Feedback Control of Macrophages In Vitro yet Has Overwhelmingly Anti-Inflammatory Consequences In Vivo by O'Neil, John D., Ross, Ewan A., Ridley, Michael L., Ding, Qize, Tang, Tina, Rosner, Dalya R., Crowley, Thomas, Malhi, Deepak, Dean, Jonathan L., Smallie, Tim, Buckley, Christopher D., Clark, Andrew R.

“…The mRNA-destabilizing factor tristetraprolin (TTP) binds in a sequence-specific manner to the 3′ untranslated regions of many proinflammatory mRNAs and…”
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