Search Results - "O'NEILL, Shane J."

Clarification of the Risk of Chronic Obstructive Pulmonary Disease in α1-Antitrypsin Deficiency PiMZ Heterozygotes by MOLLOY, Kevin, HERSH, Craig P, MORRIS, Valerie B, CARROLL, Tomás P, O'CONNOR, Catherine A, LASKY-SU, Jessica A, GREENE, Catherine M, O'NEILL, Shane J, SILVERMAN, Edwin K, MCELVANEY, Noel G

“…Severe α1-antitrypsin deficiency (typically PiZZ homozygosity) is associated with a significantly increased risk of airflow obstruction and emphysema but the…”
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miR-126 Is Downregulated in Cystic Fibrosis Airway Epithelial Cells and Regulates TOM1 Expression by Oglesby, Irene K, Bray, Isabella M, Chotirmall, Sanjay H, Stallings, Raymond L, O'Neill, Shane J, McElvaney, Noel G, Greene, Catherine M

“…Cystic fibrosis (CF) is one of the most common lethal genetic diseases in which the role of microRNAs has yet to be explored. Predicted to be regulated by…”
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α-1 Antitrypsin regulates human neutrophil chemotaxis induced by soluble immune complexes and IL-8 by Bergin, David A, Reeves, Emer P, Meleady, Paula, Henry, Michael, McElvaney, Oliver J, Carroll, Tomás P, Condron, Claire, Chotirmall, Sanjay H, Clynes, Martin, O'Neill, Shane J, McElvaney, Noel G

“…Hereditary deficiency of the protein α-1 antitrypsin (AAT) causes a chronic lung disease in humans that is characterized by excessive mobilization of…”
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Effect of Estrogen on Pseudomonas Mucoidy and Exacerbations in Cystic Fibrosis by Chotirmall, Sanjay H, Smith, Stephen G, Gunaratnam, Cedric, Cosgrove, Sonya, Dimitrov, Borislav D, O'Neill, Shane J, Harvey, Brian J, Greene, Catherine M, McElvaney, Noel G

“…Pseudomonas aeruginosa is an important pathogen in patients with cystic fibrosis. In this report, data suggest that estrogen may play a role in the modulation…”
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miR-199a-5p Silencing Regulates the Unfolded Protein Response in Chronic Obstructive Pulmonary Disease and α1-Antitrypsin Deficiency by HASSAN, Tidi, CARROLL, Tomás P, BUCKLEY, Patrick G, CUMMINS, Robert, O'NEILL, Shane J, McELVANEY, Noel G, GREENE, Catherine M

“…Retention of abnormal α1-antitrypsin (AAT) activates the unfolded protein response in AAT-deficient monocytes. The regulatory role of microRNAs (miRNAs) in…”
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Evidence for unfolded protein response activation in monocytes from individuals with alpha-1 antitrypsin deficiency by Carroll, Tomás P, Greene, Catherine M, O'Connor, Catherine A, Nolan, Aine M, O'Neill, Shane J, McElvaney, Noel G

“…The hereditary disorder alpha-1 antitrypsin (AAT) deficiency results from mutations in the SERPINA1 gene and presents with emphysema in young adults and liver…”
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TLR-Induced Inflammation in Cystic Fibrosis and Non-Cystic Fibrosis Airway Epithelial Cells by Greene, Catherine M, Carroll, Tomas P, Smith, Stephen G. J, Taggart, Clifford C, Devaney, James, Griffin, Siobhan, O'Neill, Shane J, McElvaney, Noel G

“…Cystic fibrosis (CF) is a genetic disease characterized by severe neutrophil-dominated airway inflammation. An important cause of inflammation in CF is…”
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Dysregulation of TIM-3-galectin-9 pathway in the cystic fibrosis airways by Vega-Carrascal, Isabel, Reeves, Emer P, Niki, Toshiro, Arikawa, Tomohiro, McNally, Paul, O'Neill, Shane J, Hirashima, Mitsuomi, McElvaney, Noel G

“…The T-cell Ig and mucin domain-containing molecules (TIMs) have emerged as promising therapeutic targets to correct abnormal immune function in several…”
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Neutrophil Elastase Up-Regulates Cathepsin B and Matrix Metalloprotease-2 Expression by Geraghty, Patrick, Rogan, Mark P, Greene, Catherine M, Boxio, Rachel M. M, Poiriert, Tiphaine, O'Mahony, Michael, Belaaouaj, Abderazzaq, O'Neill, Shane J, Taggart, Clifford C, McElvaney, Noel G

“…Neutrophil elastase (NE) activity is increased in many diseases. Other families of proteases, including cathepsins and matrix metalloproteases (MMPs), are also…”
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Activation of the Epidermal Growth Factor Receptor (EGFR) by a Novel Metalloprotease Pathway by Bergin, David A., Greene, Catherine M., Sterchi, Erwin E., Kenna, Cliona, Geraghty, Patrick, Belaaouaj, Abderazzaq, Taggart, Clifford C., O'Neill, Shane J., McElvaney, Noel G.

“…Neutrophil Elastase (NE) is a pro-inflammatory protease present at higher than normal levels in the lung during inflammatory disease. NE regulates IL-8…”
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17β-Estradiol Inhibits IL-8 in Cystic Fibrosis by Up-Regulating Secretory Leucoprotease Inhibitor by CHOTIRMALL, Sanjay H, GREENE, Catherine M, OGLESBY, Irene K, THOMAS, Warren, O'NEILL, Shane J, HARVEY, Brian J, MCELVANEY, Noel G

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Epithelial expression of TLR4 is modulated in COPD and by steroids, salmeterol and cigarette smoke by MacRedmond, Ruth E, Greene, Catherine M, Dorscheid, Delbert R, McElvaney, Noel G, O'Neill, Shane J

“…The toll-like receptors (TLRs) are a key component of host defense in the respiratory epithelium. Cigarette smoking is associated with increased susceptibility…”
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Elafin, an Elastase-specific Inhibitor, Is Cleaved by Its Cognate Enzyme Neutrophil Elastase in Sputum from Individuals with Cystic Fibrosis by Guyot, Nicolas, Butler, Marcus W., McNally, Paul, Weldon, Sinead, Greene, Catherine M., Levine, Rodney L., O'Neill, Shane J., Taggart, Clifford C., McElvaney, Noel G.

“…Elafin is a neutrophil serine protease inhibitor expressed in lung and displaying anti-inflammatory and anti-bacterial properties. Previous studies…”
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IL-8 Dictates Glycosaminoglycan Binding and Stability of IL-18 in Cystic Fibrosis by Reeves, Emer P, Williamson, Michael, Byrne, Barry, Bergin, David A, Smith, Stephen G. J, Greally, Peter, O'Kennedy, Richard, O'Neill, Shane J, McElvaney, Noel G

“…Dysregulation of airway inflammation contributes to lung disease in cystic fibrosis (CF). Inflammation is mediated by inflammatory cytokines, including IL-8,…”
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Tauroursodeoxycholic acid inhibits apoptosis induced by Z alpha‐1 antitrypsin via inhibition of bad by Miller, Stanley D.W., Greene, Catherine M., McLean, Caitriona, Lawless, Matthew W., Taggart, Clifford C., O'Neill, Shane J., McElvaney, Noel G.

“…Z alpha‐1 antitrypsin (AAT) deficiency is a genetic disease associated with accumulation of misfolded AAT in the endoplasmic reticulum (ER) of hepatocytes…”
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Lung involvement at presentation predicts disease activity and permanent organ damage at 6, 12 and 24 months follow - up in ANCA - associated vasculitis by Hassan, Tidi M, Hassan, Astrid S, Igoe, Ann, Logan, Mark, Gunaratnam, Cedric, McElvaney, Noel G, O'Neill, Shane J

“…Antineutrophilic cytoplasmic antibody (ANCA)-associated vasculitis (AAV) may present with pulmonary involvement ranging from mild to life-threatening disease…”
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Loss of Microbicidal Activity and Increased Formation of Biofilm Due to Decreased Lactoferrin Activity in Patients with Cystic Fibrosis by Rogan, Mark P., Taggart, Clifford C., Greene, Catherine M., Murphy, Philip G., O'Neill, Shane J., McElvaney, Noel G.

“…Intractable formation of biofilm by and infection with the opportunistic pathogen Pseudomonas aeruginosa are hallmarks of cystic fibrosis (CF). Lactoferrin, an…”
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Functional study of elafin cleaved by Pseudomonas aeruginosa metalloproteinases by Guyot, Nicolas, Bergsson, Gudmundur, Butler, Marcus W, Greene, Catherine M, Weldon, Sinéad, Kessler, Efrat, Levine, Rodney L, O'Neill, Shane J, Taggart, Clifford C, McElvaney, Noel G

“…Elafin is a 6-kDa innate immune protein present at several epithelial surfaces including the pulmonary epithelium. It is a canonical protease inhibitor of two…”
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Antimicrobial proteins and polypeptides in pulmonary innate defence by Rogan, Mark P, Geraghty, Patrick, Greene, Catherine M, O'Neill, Shane J, Taggart, Clifford C, McElvaney, Noel G

“…Inspired air contains a myriad of potential pathogens, pollutants and inflammatory stimuli. In the normal lung, these pathogens are rarely problematic. This is…”
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Intracellular Secretory Leukoprotease Inhibitor Modulates Inositol 1,4,5-Triphosphate Generation and Exerts an Anti-Inflammatory Effect on Neutrophils of Individuals with Cystic Fibrosis and Chronic Obstructive Pulmonary Disease by Alsaleh, Khalifah, Kandalaft, Osama, O'Flynn, Eimear, Geraghty, Patrick, O'Neill, Shane J., McElvaney, Noel G., McElvaney, Oliver J., Molloy, Kevin, Pohl, Kerstin, Bergin, David A., O’Reilly, Niamh, Ryan, Dorothy M., Banville, Nessa, Reeves, Emer P., Aljorfi, Ahmed

“…Secretory leukoprotease inhibitor (SLPI) is an anti-inflammatory protein present in respiratory secretions. Whilst epithelial cell SLPI is extensively studied,…”
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