Search Results - "O'NEILL, Joseph"
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The entorhinal cognitive map is attracted to goals
Published in Science (American Association for the Advancement of Science) (29-03-2019)“…Grid cells with their rigid hexagonal firing fields are thought to provide an invariant metric to the hippocampal cognitive map, yet environmental geometrical…”
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Assembly-Specific Disruption of Hippocampal Replay Leads to Selective Memory Deficit
Published in Neuron (Cambridge, Mass.) (22-04-2020)“…Memory consolidation is thought to depend on the reactivation of waking hippocampal firing patterns during sleep. Following goal learning, the reactivation of…”
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Hippocampal Reactivation of Random Trajectories Resembling Brownian Diffusion
Published in Neuron (Cambridge, Mass.) (17-04-2019)“…Hippocampal activity patterns representing movement trajectories are reactivated in immobility and sleep periods, a process associated with memory recall,…”
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The reorganization and reactivation of hippocampal maps predict spatial memory performance
Published in Nature neuroscience (01-08-2010)“…The hippocampus has place cells that preferentially fire at a particular location of spatial arena. Dupret et al . report that place fields remapped as a…”
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Assembly Responses of Hippocampal CA1 Place Cells Predict Learned Behavior in Goal-Directed Spatial Tasks on the Radial Eight-Arm Maze
Published in Neuron (Cambridge, Mass.) (02-01-2019)“…Hippocampus is needed for both spatial working and reference memories. Here, using a radial eight-arm maze, we examined how the combined demand on these…”
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Dynamic Reconfiguration of Hippocampal Interneuron Circuits during Spatial Learning
Published in Neuron (Cambridge, Mass.) (10-04-2013)“…In the hippocampus, cell assemblies forming mnemonic representations of space are thought to arise as a result of changes in functional connections of…”
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Multivariate resting-state functional connectivity predicts response to cognitive behavioral therapy in obsessive–compulsive disorder
Published in Proceedings of the National Academy of Sciences - PNAS (27-02-2018)“…Cognitive behavioral therapy (CBT) is an effective treatment for many with obsessive–compulsive disorder (OCD). However, response varies considerably among…”
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The Mental Maxwell Relations: A Thermodynamic Allegory for Higher Brain Functions
Published in Frontiers in neuroscience (28-02-2022)“…The theoretical framework of classical thermodynamics unifies vastly diverse natural phenomena and captures once-elusive effects in concrete terms…”
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Activity-dependent plasticity of hippocampal place maps
Published in Nature communications (10-06-2016)“…Hippocampal neurons encode a cognitive map of space. These maps are thought to be updated during learning and in response to changes in the environment through…”
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10
Play it again: reactivation of waking experience and memory
Published in Trends in neurosciences (Regular ed.) (01-05-2010)“…Episodic and spatial memories each involve the encoding of complex associations in hippocampal neuronal circuits. Such memory traces could be stabilised from…”
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Abuse of Amphetamines and Structural Abnormalities in the Brain
Published in Annals of the New York Academy of Sciences (01-10-2008)“…We review evidence that structural brain abnormalities are associated with abuse of amphetamines. A brief history of amphetamine use/abuse and evidence for…”
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Effects of the antidepressant medication duloxetine on brain metabolites in persistent depressive disorder: A randomized, controlled trial
Published in PloS one (19-07-2019)“…To assess whether patients with Persistent Depressive Disorder (PDD) have abnormal levels of N-acetyl-aspartate (NAA) and whether those levels normalize…”
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Parsing the Heterogeneity of Brain Metabolic Disturbances in Autism Spectrum Disorder
Published in Biological psychiatry (1969) (15-01-2020)“…Despite rising prevalence of autism spectrum disorder (ASD), its brain bases remain uncertain. Abnormal levels of N-acetyl compounds, glutamate+glutamine,…”
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Optogenetically Blocking Sharp Wave Ripple Events in Sleep Does Not Interfere with the Formation of Stable Spatial Representation in the CA1 Area of the Hippocampus
Published in PloS one (19-10-2016)“…During hippocampal sharp wave/ripple (SWR) events, previously occurring, sensory input-driven neuronal firing patterns are replayed. Such replay is thought to…”
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Optogenetic inhibition-mediated activity-dependent modification of CA1 pyramidal-interneuron connections during behavior
Published in eLife (05-10-2020)“…In vitro work revealed that excitatory synaptic inputs to hippocampal inhibitory interneurons could undergo Hebbian, associative, or non-associative…”
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Interaction of methamphetamine abuse, tobacco abuse, and gender in the brain
Published in The American journal of drug and alcohol abuse (2015)Get full text
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FMRI hemodynamic response function (HRF) as a novel marker of brain function: applications for understanding obsessive-compulsive disorder pathology and treatment response
Published in Brain imaging and behavior (01-06-2021)“…The hemodynamic response function (HRF) represents the transfer function linking neural activity with the functional MRI (fMRI) signal, modeling neurovascular…”
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Identification of a polymorphism within the Rosa multiflora muRdr1A gene linked to resistance to multiple races of Diplocarpon rosae W. in tetraploid garden roses (Rosa × hybrida)
Published in Theoretical and applied genetics (2020)“…Key message A QTL for resistance to several races of black spot co-located with the known Rrd1 locus in Rosa. A polymorphism in muRdr1A linked to black spot…”
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Graph-theoretical analysis of resting-state fMRI in pediatric obsessive–compulsive disorder
Published in Journal of affective disorders (15-03-2016)“…Abstract Background fMRI graph theory reveals resting-state brain networks, but has never been used in pediatric OCD. Methods Whole-brain resting-state fMRI…”
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Higher glutamatergic activity in the medial prefrontal cortex in chronic ketamine users
Published in Journal of psychiatry & neuroscience (01-07-2022)“…Background: The medial prefrontal cortex (mPFC) plays an important role in depression and addiction. Previous studies have shown alterations in glutamatergic…”
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