Search Results - "O'NEILL, G. P"

The discovery of rofecoxib, [MK 966, VIOXX ®, 4-(4′-methylsulfonylphenyl)-3-phenyl-2(5 H)-furanone], an orally active cyclooxygenase-2 inhibitor by Prasit, P, Wang, Z, Brideau, C, Chan, C.-C, Charleson, S, Cromlish, W, Ethier, D, Evans, J.F, Ford-Hutchinson, A.W, Gauthier, J.Y, Gordon, R, Guay, J, Gresser, M, Kargman, S, Kennedy, B, Leblanc, Y, Léger, S, Mancini, J, O'Neill, G.P, Ouellet, M, Percival, M.D, Perrier, H, Riendeau, D, Rodger, I, Tagari, P, Thérien, M, Vickers, P, Wong, E, Xu, L.-J, Young, R.N, Zamboni, R, Boyce, S, Rupniak, N, Forrest, M, Visco, D, Patrick, D

“…The development of a COX-2 inhibitor rofecoxib (MK 966, Vioxx®) is described. It is essentially equipotent to indomethacin both in vitro and in vivo but…”
Get full text

Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles by Chan, C C, Boyce, S, Brideau, C, Charleson, S, Cromlish, W, Ethier, D, Evans, J, Ford-Hutchinson, A W, Forrest, M J, Gauthier, J Y, Gordon, R, Gresser, M, Guay, J, Kargman, S, Kennedy, B, Leblanc, Y, Leger, S, Mancini, J, O'Neill, G P, Ouellet, M, Patrick, D, Percival, M D, Perrier, H, Prasit, P, Rodger, I

“…The discoveries that cyclooxygenase (COX)-2 is an inducible form of COX involved in inflammation and that COX-1 is the major isoform responsible for the…”
Get more information

Expression of the cysteinyl leukotriene 1 receptor in normal human lung and peripheral blood leukocytes by FIGUEROA, David J, BREYER, Richard M, JONES, Thomas R, LYNCH, Kevin R, AUSTIN, Christopher P, EVANS, Jilly F, DEFOE, Stephanie K, KARGMAN, Stacia, DAUGHERTY, Bruce L, WALDBURGER, Kristine, QINGYUN LIU, CLEMENTS, Michelle, ZHIZEN ZENG, O'NEILL, Gary P

“…The cysteinyl leukotrienes (CysLTs) are important mediators of human asthma. Pharmacologic and clinical studies show that the CysLTs exert most of their…”
Get full text

Molecular Characterization and Expression of Cloned Human Galanin Receptors GALR2 and GALR3 by Kolakowski, Lee F., O'Neill, Gary P., Howard, Andrew D., Broussard, Suzanne R., Sullivan, Kathleen A., Feighner, Scott D., Sawzdargo, Marek, Nguyen, Tuan, Kargman, Stacia, Shiao, Lin‐Lin, Hreniuk, Donna L., Tan, Carina P., Evans, Jilly, Abramovitz, Mark, Chateauneuf, Anne, Coulombe, Nathalie, Ng, Gordon, Johnson, Michael P., Tharian, Anita, Khoshbouei, Habibeh, George, Susan R., Smith, Roy G., O'Dowd, Brian F.

“…: Galanin is a 29‐ or 30‐amino acid peptide with wide‐ranging effects on hormone release, feeding behavior, smooth muscle contractility, and somatosensory…”
Get full text

Overexpression of human prostaglandin G/H synthase-1 and -2 by recombinant vaccinia virus: inhibition by nonsteroidal anti-inflammatory drugs and biosynthesis of 15-hydroxyeicosatetraenoic acid by O'Neill, G P, Mancini, J A, Kargman, S, Yergey, J, Kwan, M Y, Falgueyret, J P, Abramovitz, M, Kennedy, B P, Ouellet, M, Cromlish, W

“…Human prostaglandin G/H synthase (hPGHS)-1 and hPGHS-2, key enzymes in the formation of prostanoids from arachidonic acid, were expressed at high levels in…”
Get more information

Activation of the human peripheral cannabinoid receptor results in inhibition of adenylyl cyclase by Slipetz, D M, O'Neill, G P, Favreau, L, Dufresne, C, Gallant, M, Gareau, Y, Guay, D, Labelle, M, Metters, K M

“…The human peripheral cannabinoid (CB2) receptor has been cloned by reverse transcription-polymerase chain reaction from human spleen RNA and expressed, to…”
Get more information

Characterization of the human cysteinyl leukotriene CysLT1 receptor by LYNCH, K. R, O'NEILL, G. P, CONNOLLY, B. M, CHANG BAI, AUSTIN, C. P, CHATEAUNEUF, A, STOCCO, R, GREIG, G. M, KARGMAN, S, HOOKS, S. B, HOSFIELD, E, WILLIAMS, D. L, QINGYUN LIU, FORD-HUTCHINSON, A. W, CASKEY, C. T, EVANS, J. F, IM, D.-S, SAWYER, N, METTERS, K. M, COULOMBE, N, ABRAMOVITZ, M, FIGUEROA, D. J, ZHIZHEN ZENG

“…The cysteinyl leukotrienes-leukotriene C4(LTC4), leukotriene D4(LTD4) and leukotriene E4(LTE4)-are important mediators of human bronchial asthma…”
Get full text

Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD2 receptors CRTH2 and DP by Gervais, Francois G., Cruz, Rani P.G., Chateauneuf, Anne, Gale, Stephen, Sawyer, Nicole, Nantel, Francois, Metters, Kathleen M., O'Neill, Gary P.

“…Background: PGD2 is the major prostanoid released by mast cells during an allergic response. Its role in the allergic response, however, remains unclear…”
Get full text

Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancer by KARGMAN, S. L, O'NEILL, G. P, VICKERS, P. J, EVANS, J. F, MANCINI, J. A, JOTHY, S

“…Prostaglandin G/H synthase (PGHS), a key enzyme leading to the formation of prostaglandins, is the target of nonsteroidal antiinflammatory drugs. Two forms of…”
Get full text

Mechanism of selective inhibition of human prostaglandin G/H synthase-1 and -2 in intact cells by Kargman, Stacia, Wong, Elizabeth, Greig, Gillian M., Falgueyret, Jean-Pierre, Cromlish, Wanda, Ethier, Diane, Yergey, Jim A., Riendeau, Denis, Evans, Jilly F., Kennedy, Brian, Tagari, Philip, Francis, Donna A., O'Neill, Gary P.

“…Selective inhibitors of prostaglandin synthase-2 (PGHS-2) possess potent anti-inflammatory, antipyretic, and analgesic properties but demonstrate reduced…”
Get full text

The iron chelator desferrioxamine attenuates postischemic ventricular dysfunction by Bolli, R, Patel, B S, Zhu, W X, O'Neill, P G, Hartley, C J, Charlat, M L, Roberts, R

“…Recent evidence suggests that postischemic myocardial dysfunction ("stunning") may be mediated by oxygen free radicals, but the mechanism by which they produce…”
Get full text

Characterization of the Human Cysteinyl Leukotriene 2 Receptor by Heise, Christopher E., O'Dowd, Brian F., Figueroa, David J., Sawyer, Nicole, Nguyen, Tuan, Im, Dong-Soon, Stocco, Rino, Bellefeuille, Julie N., Abramovitz, Mark, Cheng, Regina, Williams, David L., Zeng, Zhizhen, Liu, Qingyun, Ma, Lei, Clements, Michelle K., Coulombe, Nathalie, Liu, Yuan, Austin, Christopher P., George, Susan R., O'Neill, Gary P., Metters, Kathleen M., Lynch, Kevin R., Evans, Jilly F.

“…The contractile and inflammatory actions of the cysteinyl leukotrienes (CysLTs), LTC4, LTD4, and LTE4, are thought to be mediated through at least two distinct…”
Get full text

Mutation of serine-516 in human prostaglandin G/H synthase-2 to methionine or aspirin acetylation of this residue stimulates 15- R-HETE synthesis by Mancini, Joseph A., O'Neill, Gary P., Bayly, Christopher, Vickers, Philip J.

“…Prostaglandin G/H synthase (PGHS) is a key enzyme in cellular prostaglandin (PG) synthesis and is the target of non-steroidal anti-inflammatory agents. PGHS…”
Get full text

Authorship patterns in theory based versus research based journals by O'NEILL, G. P

Get full text

Discovery of a receptor related to the galanin receptors by Lee, Dennis K, Nguyen, Tuan, O'Neill, Gary P, Cheng, Regina, Liu, Yang, Howard, Andrew D, Coulombe, Nathalie, Tan, Carina P, Tang-Nguyen, Anh-Thi, George, Susan R, O'Dowd, Brian F

“…We report the isolation of a cDNA clone named GPR54, which encodes a novel G protein-coupled receptor (GPCR). A PCR search of rat brain cDNA retrieved a clone…”
Get full text

Evidence for a pathogenetic role of xanthine oxidase in the "stunned" myocardium by Charlat, M I, O'Neill, P G, Egan, J M, Abernethy, D R, Michael, L H, Myers, M L, Roberts, R, Bolli, R

“…Recent evidence suggests that postischemic myocardial dysfunction (or myocardial "stunning") may be mediated by oxygen free radicals, but the mechanism for…”
Get full text

Characterization of autocrine inducible prostaglandin H synthase-2 (PGHS-2) in human osteosarcoma cells by Wong, E, DeLuca, C, Boily, C, Charleson, S, Cromlish, W, Denis, D, Kargman, S, Kennedy, B P, Ouellet, M, Skorey, K, O'Neill, G P, Vickers, P J, Riendeau, D

“…The human osteosarcoma 143.98.2 cell line was found to express high levels of prostaglandin synthase-2 (PGHS-2) without detectable levels of prostaglandin…”
Get full text

The C3a receptor antagonist SB 290157 has agonist activity by Mathieu, Marie-Claude, Sawyer, Nicole, Greig, Gillian M., Hamel, Martine, Kargman, Stacia, Ducharme, Yves, Lau, Cheuk K., Friesen, Richard W., O’Neill, Gary P., Gervais, Francois G., Therien, Alex G.

“…The anaphylatoxin C3a is an important immune regulator with a number of distinct functions in both innate and adaptive immunity. Many of these roles have been…”
Get full text

Expression of the Synechocystis sp. strain PCC 6803 tRNA(Glu) gene provides tRNA for protein and chlorophyll biosynthesis by O'Neill, G.P. (Yale University, New Haven, CT), Soll, D

“…In the cyanobacterium Synechocystis sp. strain PCC 6803 (Synechocystis 6803) delta-aminolevulinic acid (ALA), the sole precursor for the synthesis of the…”
Get full text

Cross-species comparison of 5-lipoxygenase-activating protein by Vickers, P J, O'Neill, G P, Mancini, J A, Charleson, S, Abramovitz, M

“…To identify regions of 5-lipoxygenase-activating protein (FLAP) important for the function of the protein and the binding of leukotriene biosynthesis…”
Get more information