Search Results - "O'NEILL, C. J. A"

Objective measurement of activation of rigidity: diagnostic, pathogenetic and therapeutic implications in parkinsonism by KIROLLOS, C., CHARLETT, A., O'NEILL, C. J. A., KOSIK, R., MOZOL, K., PURKISS, A. G., BOWES, S. G., NICHOLSON, P. W., HUNT, W. B., WELLER, C., DOBBS, S. M., DOBBS, R. J.

“…1Quantification of the effect on rigidity of its ‘activation’, by isometric grip, of standardized pressure, of the contralateral hand, was explored. Torque…”
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Is This Walk Normal? by DOBBS, R. J., CHARLETT, A., BOWES, S. G., O'NEILL, C. J. A., WELLER, C., HUGHES, J., DOBBS, S. M.

“…Data from 144 volunteers, aged 30–89 years, judged to be healthy according to stated criteria, are used to construct speed and height-specific reference ranges…”
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Hypothesis: Age-associated Changes in Gait Represent, in Part, a Tendency towards Parkinsonism by DOBBS, R. J., LUBEL, D. D., CHARLETT, A., BOWES, S. G., O'NEILL, C. J. A., WELLER, C., DOBBS, S. M.

“…In 144 healthy, active, asymptomatic volunteers (aged 30–88 years), age explained 33% of the variance in free walking speed. This could not be ascribed simply…”
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Time course of physical and psychological responses to selegiline monotherapy in newly diagnosed, idiopathic parkinosonism by KIROLLOS, C, CHARLETT, A, DOBBS, R. J, DOBBS, S. M, BOWES, S. G, PURKISS, A. G, O'NEILL, C. J. A, WELLER, C, DICKINS, J, FAULKNER, G, NICHOLSON, P. W, HUNT, W. B

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Quantification of the Cardinal Signs of Parkinsonism and of Associated Disability in Spouses of Sufferers by KIROLLOS, C., O'NEILL, C. J. A., DOBBS, R. J., CHARLETT, A., BOWES, S. G., WELLER, C., PURKISS, A. G., HUNT, W. B., DOBBS, S. M.

“…Work on the causation of idiopathic parkinsonism is limited by relying on gross clinical definition and lack of studies in the old. A prognostic index for…”
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Assessment of the bradyphrenia of parkinsonism: a novel use of delayed auditory feedback by Dobbs, R J, Bowes, S G, Henley, M, Charlett, A, O'Neill, C J, Dickins, J, Nicholson, P W, Dobbs, S M

“…Sufferers from parkinsonism have difficulty shifting or developing an appropriate mental set. Delayed auditory feedback may, therefore, disrupt their speech…”
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Objective evidence for tolerance, against a background of improvement, during maintenance therapy with controlled release levodopa/carbidopa by BOWES, S. G, DOBBS, R. J, HENLEY, M, CHARLETT, A, O'NEILL, C. J. A, NICHOLSON, P. W, PURKISS, A. G, WELLER, C, DOBBS, S. M

“…We have investigated whether the potential benefits of a controlled release formulation of levodopa (200 mg)/carbidopa (50 mg), Sinemet CR, are realised during…”
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Measurement of Compliance with Medication: The sine qua non of Clinical Trials in Old Age? by O'NEILL, C. J. A., DOBBS, R. J., DOBBS, S. M., NICHOLSON, P. W.

“…The use of devices for measuring the compliance with medication in the elderly is discussed. Clinical trials in older people are jeopardized by poor compliance…”
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Effect of duration of levodopa/decarboxylase inhibitor therapy on the pharmacokinetic handling of levodopa in elderly patients with idiopathic Parkinson's disease by BOWES, S. G, O'NEILL, C. J. A, NICHOLSON, P. W, LEEMAN, A. L, DESHMUKH, A. A, DOBBS, R. J, DOBBS, S. M

“…We address, from a pharmacokinetic viewpoint, the important question of why some patients with clinical idiopathic Parkinson's disease experience a fall off in…”
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Evaluation of the safety of enalapril in the treatment of heart failure in the very old by O'NEILL, C. J. A, BOWES, S. G, SULLENS, C. M, ROYSTON, J. P, HUNT, W. B, DENHAM, M. J, DOBBS, R. J, DOBBS, S. M

“…We have introduced enalapril, in doses equal to or less than the 2.5 mg currently recommended, as an adjuvant to digoxin and diuretics in 17 patients of mean…”
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Therapeutic drug monitoring of digoxin: help or hindrance? by DOBBS, R. J, NICHOLSON, P. W, DENHAM, M. J, DOBBS, S. M, O'NEILL, C. J. A

“…A major role of therapeutic drug monitoring services is to advise on the dose of a drug which would be required to bring the concentration in the blood to…”
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GOTcha： IncRNA-ACOD1 targets metabolism during viral infection by Marah C Runtsch;Luke AJ O＇Neill

“…Long-noncoding RNAs （lncRNAs） are emerging as important regulators of cellular processes, but few have been functionally characterized in host-pathogen…”
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Prescribing digoxin in geriatric units: the unexplained variability in dosage requirements by DOBBS, R. J, ROYSTON, J. P, O'NEILL, C. J. A, DESHMUKH, A. A, NICHOLSON, P. W, DENHAM, M. J, DOBBS, S. M

“…Some physicians regard patients of Geriatric Units as a homogeneous population with respect to digoxin dosage requirements. Others advocate the use of…”
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Measurement of compliance with medication: the sine qua non of clinical trials in old age? by O'Neill, C J A, Dobbs, R J, Dobbs, S M

“…Notes the need for definitions of compliance which relate to efficacy and effectiveness. Discusses problems of measurement and devices for monitoring…”
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Defining small differences in efficacy between anti‐parkinsonian agents using gait analysis: a comparison of two controlled release formulations of levodopa/decarboxylase inhibitor by Weller, C, O'Neill, CJ, Charlett, A, Bowes, SG, Purkiss, A, Nicholson, PW, Dobbs, RJ, Dobbs, SM

“…1. Stride length is highly relevant to mobility and is sensitive to the effects of levodopa in Parkinsonism. Its selection as the primary outcome criterion…”
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Parkinsonism : myths, dogma and the hope of prophylaxis. Commentary by DOBBS, R. J, DOBBS, S. M, BOWES, S. G, O'NEILL, C. J. A, CHARLETT, A

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Determinants of gait in the elderly parkinsonian on maintenance levodopa/carbidopa therapy by Bowes, SG, Clark, PK, Leeman, AL, O'Neill, CJ, Weller, C, Nicholson, PW, Deshmukh, AA, Dobbs, SM, Dobbs, RJ

“…1. We have used gait analysis to investigate the efficacy of maintenance therapy with a levodopa/carbidopa combination in patients with idiopathic…”
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Could seborrhoeic dermatitis be implicated in the pathogenesis of parkinsonism? by O'Neill, C J, Richardson, M D, Charlett, A, McHugh, L, Bowes, S G, Purkiss, A G, Weller, C, Dobbs, S M, Dobbs, R J

“…The spouses of a group of aged sufferers have been demonstrated to have multifarious differences relevant to parkinsonism from matched controls, which were…”
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Serum concentration monitoring of cardiac glycosides : how helpful is it for adjusting dosage regimens ? by DOBBS, R. J, O'NEILL, C. J. A, DESHMUKH, A. A, NICHOLSON, P. W, DOBBS, S. M

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A quinine a day keeps the leg cramps away? by Warburton, A, Royston, JP, O'Neill, CJ, Nicholson, PW, Jee, RD, Denham, MJ, Dobbs, SM, Dobbs, RJ

“…A double‐blind, placebo‐controlled, cross‐over trial of quinine in leg cramps occurring at rest was conducted in 22 elderly cramp sufferers. Despite…”
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