Search Results - "O'NEAL, W. K"

Contribution of mucus concentration and secreted mucins Muc5ac and Muc5b to the pathogenesis of muco-obstructive lung disease by Livraghi-Butrico, A, Grubb, B R, Wilkinson, K J, Volmer, A S, Burns, K A, Evans, C M, O’Neal, W K, Boucher, R C

“…Airway diseases, including cigarette smoke-induced chronic bronchitis, cystic fibrosis, and primary ciliary dyskinesia are associated with decreased…”
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Expression of CFTR from a ciliated cell-specific promoter is ineffective at correcting nasal potential difference in CF mice by OSTROWSKI, L. E, YIN, W, DIGGS, P. S, ROGERS, T. D, O'NEAL, W. K, GRUBB, B. R

“…Successful gene therapy will require that the therapeutic gene be expressed at a sufficient level in the correct cell type(s). To improve the specificity of…”
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Mucus clearance, MyD88-dependent and MyD88-independent immunity modulate lung susceptibility to spontaneous bacterial infection and inflammation by Livraghi-Butrico, A, Kelly, E J, Klem, E R, Dang, H, Wolfgang, M C, Boucher, R C, Randell, S H, O'Neal, W K

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Membrane Mucin Muc4 promotes blood cell association with tumor cells and mediates efficient metastasis in a mouse model of breast cancer by Rowson-Hodel, A R, Wald, J H, Hatakeyama, J, O'Neal, W K, Stonebraker, J R, VanderVorst, K, Saldana, M J, Borowsky, A D, Sweeney, C, Carraway, K L

“…Mucin-4 (Muc4) is a large cell surface glycoprotein implicated in the protection and lubrication of epithelial structures. Previous studies suggest that…”
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Endoplasmic reticulum stress in chronic obstructive lung diseases by Ribeiro, C M P, O'Neal, W K

“…Chronic airway inflammation characterizes several airway diseases, including cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD). The altered…”
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The ER stress transducer IRE1β is required for airway epithelial mucin production by Martino, M B, Jones, L, Brighton, B, Ehre, C, Abdulah, L, Davis, C W, Ron, D, O'Neal, W K, Ribeiro, C M P

“…Inflammation of human bronchial epithelia (HBE) activates the endoplasmic reticulum (ER) stress transducer inositol-requiring enzyme 1 (IRE1)α, resulting in…”
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Mucus clearance, MyD88-dependent and MyD88-independent immunity modulate lung susceptibility to spontaneous bacterial infection and inflammation by Livraghi-Butrico, A, Kelly, E J, Klem, E R, Dang, H, Wolfgang, M C, Boucher, R C, Randell, S H, O'Neal, W K

“…It has been postulated that mucus stasis is central to the pathogenesis of obstructive lung diseases. In Scnn1b- transgenic ( Scnn1b -Tg + ) mice,…”
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Contribution of mucus concentration and secreted mucins Muc5ac and Muc5b to the pathogenesis of muco-obstructive lung disease by Livraghi-Butrico, A, Grubb, B R, Wilkinson, K J, Volmer, A S, Burns, K A, Evans, C M, O'Neal, W K, Boucher, R C

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Cloning and functional characterization of two murine uridine nucleotide receptors reveal a potential target for correcting ion transport deficiency in cystic fibrosis gallbladder by Lazarowski, E R, Rochelle, L G, O'Neal, W K, Ribeiro, C M, Grubb, B R, Zhang, V, Harden, T K, Boucher, R C

“…Extracellular nucleotides regulate transepithelial ion secretion via multiple receptors. The P2Y(2) receptor is the predominant transducer of chloride…”
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Transgenic hCFTR expression fails to correct β-ENaC mouse lung disease by Grubb, B R, O'Neal, W K, Ostrowski, L E, Kreda, S M, Button, B, Boucher, R C

“…The relationships between airway epithelial Cl(-) secretion-Na(+) absorption balance, airway surface liquid (ASL) homeostasis, and lung disease were…”
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Somatic gene therapy for cystic fibrosis by O'Neal, W K, Beaudet, A L

“…There is considerable potential to ameliorate the pulmonary disease in cystic fibrosis (CF) using somatic gene therapy. Even low levels of expression of the…”
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Clinical Significance of Bronchodilator Responsiveness Evaluated by Forced Vital Capacity in COPD: SPIROMICS Cohort Analysis [Corrigendum] by Barjaktarevic, Igor, Buhr, Russell G, Wang, Xiaoyan, Hu, Scott, Couper, David, Anderson, Wayne, Kanner, Richard E, Paine III, Robert, Bhatt, Surya P, Bhakta, Nirav R, Arjomandi, Mehrdad, Kaner, Robert J, Pirozzi, Cheryl S, Curtis, Jeffrey L, O'Neal, Wanda K, Woodruff, Prescott G, Han, MeiLan K, Martinez, Fernando J, Hansel, Nadia, Wells, James Michael, Ortega, Victor E, Hoffman, Eric, Doerschuk, Claire M, Kim, Victor, Dransfield, Mark T, Drummond, M Bradley, Bowler, Russell, Criner, Gerard, Christenson, Stephanie A, Ronish, Bonnie, Peters, Stephen, Krishnan, Jerry A, Tashkin, Donald, Cooper, Christopher

“…Funding This study was supported by R01HL125432-01A1 (MBD), T32HL007106-41 (RMB), and TL1TR001883-01 (RGB). SPIROMICS was supported by contracts from the…”
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Lethal toxicity, severe endothelial injury, and a threshold effect with high doses of an adenoviral vector in baboons by Morral, Núria, O'Neal, Wanda K, Rice, Karen, Leland, M Michelle, Piedra, Pedro A, Aguilar-Córdova, Estuardo, Carey, K Dee, Beaudet, Arthur L, Langston, Claire

“…The effects of intravenous administration of a first-generation adenoviral vector expressing beta-galactosidase were compared in two baboons receiving a high…”
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Toxicity associated with repeated administration of first-generation adenovirus vectors does not occur with a helper-dependent vector by O'Neal, W K, Zhou, H, Morral, N, Langston, C, Parks, R J, Graham, F L, Kochanek, S, Beaudet, A L

“…Certain gene therapy protocols may require multiple administrations of vectors to achieve therapeutic benefit to the patient. This may be especially relevant…”
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Identification of Dynein Heavy Chain 7 as an Inner Arm Component of Human Cilia That Is Synthesized but Not Assembled in a Case of Primary Ciliary Dyskinesia by Zhang, Yan J., O'Neal, Wanda K., Randell, Scott H., Blackburn, Kevin, Moyer, Mary B., Boucher, Richard C., Ostrowski, Lawrence E.

“…Although the basic structure of the axoneme has been highly conserved throughout evolution, the varied functions of specialized axonemes require differences in…”
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A severe phenotype in mice with a duplication of exon 3 in the cystic fibrosis locus by O'Neal, W K, Hasty, P, McCray, Jr, P B, Casey, B, Rivera-Pérez, J, Welsh, M J, Beaudet, A L, Bradley, A

“…To develop an animal model for cystic fibrosis (CF), targeted gene disruption in embryonic stem (ES) cells was used to generate a duplication of exon 3…”
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B21 GENETICS, GENOMICS, AND GENE EXPRESSION IN ASTHMA AND COPD: Quantitative Genetic Analysis Of Muc5ac And Muc5b In A Mouse Model Of Asthma by Kelada, S, Livraghi-Butrico, A, McFadden, K, Thomas, J, O'Neal, W K, Boucher, R C

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B98 MAKING SENSE OF AIRWAY REMODELING: LEARNING TO COMMUNICATE: Intercellular Communication Between The Airway Epithelial Cells Is Mediated By Exosomes Like Vesicles by Gupta, R, Abdelwahab, S, Jones, L, Dang, H, O'Neal, W K, Kesimer, M

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C60 ALL ABOUT CYSTIC FIBROSIS: Il1r1 Regulates Muc5b Production And Inflammatory Responses In The Airway Epithelium by Chen, G, O'Neal, W K, Deng, Y, Yu, D, Jones, L, Ribeiro, C, Randell, S H, Boucher, R C

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C60 ALL ABOUT CYSTIC FIBROSIS: Spdef-Independent Mucin Production During Non-Th2-Dominated Pulmonary Inflammation Revealed In The Scnn1b-Tg Muco-Obstructive Mouse Model by Chen, G, Volmer, A, Wilkinson, K, Terrell, K, O'Neal, W K, Livraghi-Butrico, A, Boucher, R C

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