Search Results - "O'Melia, Meghan J"

Thermosensitive hydrogel releasing nitric oxide donor and anti-CTLA-4 micelles for anti-tumor immunotherapy by Kim, Jihoon, Francis, David M., Sestito, Lauren F., Archer, Paul A., Manspeaker, Margaret P., O’Melia, Meghan J., Thomas, Susan N.

“…Due to their autosynchronous roles in shaping the anti-tumor immune response, complex immune regulatory networks acting both locally within the tumor…”
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Lymphatics drain nanoparticles from tumours by O’Melia, Meghan J., Thomas, Susan N.

“…Lymphatic vessels within and near to tumours facilitate nanoparticle transport out of tumours, with ramifications in the design and implementation of…”
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Synthetic Matrix Scaffolds Engineer the In Vivo Tumor Immune Microenvironment for Immunotherapy Screening by O'Melia, Meghan J., Mulero‐Russe, Adriana, Kim, Jihoon, Pybus, Alyssa, DeRyckere, Deborah, Wood, Levi, Graham, Douglas K., Botchwey, Edward, García, Andrés J., Thomas, Susan N.

“…Immunotherapy has emerged as one of the most powerful anti‐cancer therapies but is stymied by the limits of existing preclinical models with respect to disease…”
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The Biophysics of Lymphatic Transport: Engineering Tools and Immunological Consequences by O'Melia, Meghan J., Lund, Amanda W., Thomas, Susan N.

“…Lymphatic vessels mediate fluid flows that affect antigen distribution and delivery, lymph node stromal remodeling, and cell-cell interactions, to thus…”
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Elicitation of stem-like CD8+ T cell responses via lymph node-targeted chemoimmunotherapy evokes systemic tumor control by Manspeaker, Margaret P, O'Melia, Meghan J, Thomas, Susan N

“…BackgroundTumor-draining lymph nodes (TdLNs) are critical in the regulation of local and systemic antitumor T cell immunity and are implicated in coordinating…”
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Lymph Node Subcapsular Sinus Microenvironment-On-A-Chip Modeling Shear Flow Relevant to Lymphatic Metastasis and Immune Cell Homing by Birmingham, Katherine G., O'Melia, Meghan J., Bordy, Samantha, Reyes Aguilar, David, El-Reyas, Bassel, Lesinski, Gregory, Thomas, Susan N.

“…A lymph node sinus-on-a-chip adhesion microfluidic platform that recapitulates the hydrodynamic microenvironment of the lymph node subcapsular sinus was…”
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Hydrodynamic shear-based purification of cancer cells with enhanced tumorigenic potential by Cermeño, Efraín A, O'Melia, Meghan J, Han, Woojin M, Veith, Austin, Barber, Graham, Huang, Emina H, Thomas, Susan N, García, Andrés J

“…Tumor-initiating cells (TICs), a subpopulation of cancerous cells with high tumorigenic potential and stem-cell-like properties, drive tumor progression and…”
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Quantitation of lymphatic transport mechanism and barrier influences on lymph node-resident leukocyte access to lymph-borne macromolecules and drug delivery systems by Archer, Paul A., Sestito, Lauren F., Manspeaker, Margaret P., O’Melia, Meghan J., Rohner, Nathan A., Schudel, Alex, Mei, Yajun, Thomas, Susan N.

“…Lymph nodes (LNs) are tissues of the immune system that house leukocytes, making them targets of interest for a variety of therapeutic immunomodulation…”
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Tumor-draining lymph nodes are survival niches that support T cell priming against lymphatic transported tumor antigen and effects of immune checkpoint blockade in TNBC by O’Melia, Meghan J., Manspeaker, Margaret P., Thomas, Susan N.

“…Triple negative breast cancer (TNBC) is a significant clinical problem to which immunotherapeutic strategies have been applied with limited success. Using the…”
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Cancer cell plasticity and MHC-II-mediated immune tolerance promote breast cancer metastasis to lymph nodes by Lei, Pin-Ji, Pereira, Ethel R, Andersson, Patrik, Amoozgar, Zohreh, Van Wijnbergen, Jan Willem, O'Melia, Meghan J, Zhou, Hengbo, Chatterjee, Sampurna, Ho, William W, Posada, Jessica M, Kumar, Ashwin S, Morita, Satoru, Menzel, Lutz, Chung, Charlie, Ergin, Ilgin, Jones, Dennis, Huang, Peigen, Beyaz, Semir, Padera, Timothy P

“…Tumor-draining lymph nodes (TDLNs) are important for tumor antigen-specific T cell generation and effective anticancer immune responses. However, TDLNs are…”
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Analyzing Mechanisms of Metastatic Cancer Cell Adhesive Phenotype Leveraging Preparative Adhesion Chromatography Microfluidic by Birmingham, Katherine G., O'Melia, Meghan J., Ban, Dongjo, Mouw, Janna, Edwards, Erin E., Marcus, Adam I., McDonald, John, Thomas, Susan N.

“…An integrated, parallel‐plate microfluidic device is engineered to interrogate and fractionate cells based on their adhesivity to a substrate surface…”
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577 Cancer immunotherapy responses persist after lymph node resection by Zhou, Hengbo, O’Melia, Meghan J, Baish, James W, Darragh, Laurel B, Lei, Pinji, Menzel, Lutz, Rajotte, Johanna J, Nikmaneshi, Mohammad R, Razavi Rizi, Mohammad S, Vander Heiden, Matthew G, Munn, Lance L, Karam, Sana D, Padera, Timothy P

“…BackgroundLymph nodes (LNs) are secondary lymphoid organs that surveil tissue fluids and initiate adaptive immunity. Due to the direct drainage of interstitial…”
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Three-Channel Fluorescence Lifetime Imaging of Endogenous Fluorophores by Svindrych, Zdenek, Wallrabe, Horst, Rehman, Shagufta, O'Melia, Meghan J., Periasamy, Ammasi

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Abstract 1298: Single cell analysis of breast cancer progression and metastasis to lymph nodes reveals cancer cell plasticity and MHC class II-mediated immune regulation by Lei, Pin-Ji, Pereira, Ethel, Andersson, Patrik, Amoozgar, Zohreh, Van Wijnbergen, Jan Willem, O'Melia, Meghan J., Zhou, Hengbo, Chatterjee, Sampurna, Ho, William Wee, Posada, Jessica M., Kumar, Ashwin Srinivasan, Morita, Satoru, Chuang, Charlie, Ergin, Ilgin, Jones, Dennis, Huang, Peigen, Beyaz, Semir, Padera, Timothy P.

“…Abstract Tumor-draining lymph nodes are critical sites for generating tumor antigen-specific T cells and are associated with durable immune responses. However,…”
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