Search Results - "O'Malley, Ronan"
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Cistrome and Epicistrome Features Shape the Regulatory DNA Landscape
Published in Cell (19-05-2016)“…The cistrome is the complete set of transcription factor (TF) binding sites (cis-elements) in an organism, while an epicistrome incorporates tissue-specific…”
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Mapping genome-wide transcription-factor binding sites using DAP-seq
Published in Nature protocols (01-08-2017)“…This protocol describes DAP-seq, a transcription-factor binding site discovery assay that can be used to produce cistrome and epicistrome maps for any…”
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High-Throughput Single-Cell Transcriptome Profiling of Plant Cell Types
Published in Cell reports (Cambridge) (14-05-2019)“…Single-cell transcriptome profiling of heterogeneous tissues can provide high-resolution windows into developmental dynamics and environmental responses, but…”
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Persistence and plasticity in bacterial gene regulation
Published in Nature methods (01-12-2021)“…Organisms orchestrate cellular functions through transcription factor (TF) interactions with their target genes, although these regulatory relationships are…”
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Transcriptome and DNA methylome divergence of inflorescence development between 2 ecotypes in Panicum hallii
Published in Plant physiology (Bethesda) (03-07-2023)“…Abstract The morphological diversity of the inflorescence determines flower and seed production, which is critical for plant adaptation. Hall's panicgrass…”
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Highly Integrated Single-Base Resolution Maps of the Epigenome in Arabidopsis
Published in Cell (02-05-2008)“…Deciphering the multiple layers of epigenetic regulation that control transcription is critical to understanding how plants develop and respond to their…”
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Phased diploid genome assembly with single-molecule real-time sequencing
Published in Nature methods (01-12-2016)“…The open-source FALCON and FALCON-Unzip software utilize long-read sequencing data to generate contiguous, accurate and phased diploid assemblies, even from…”
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IgG4 Disease-Related Ataxia
Published in Cerebellum (London, England) (01-06-2024)“…We describe a male patient presenting with cerebellar ataxia and behavioural frontotemporal dementia in whom imaging showed cerebellar atrophy. He had…”
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Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells
Published in Nature (London) (03-03-2011)“…Induced pluripotent stem cells (iPSCs) offer immense potential for regenerative medicine and studies of disease and development. Somatic cell reprogramming…”
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A Qualitative Meta-Analysis Exploring Client-Reported Outcomes of Couple Therapy
Published in Psychotherapy (Chicago, Ill.) (01-12-2023)“…The quantitative reviews of the outcome research on couple therapy show that this type of therapy can produce positive outcomes for couples and improve…”
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The regulatory and transcriptional landscape associated with carbon utilization in a filamentous fungus
Published in Proceedings of the National Academy of Sciences - PNAS (17-03-2020)“…Filamentous fungi, such as Neurospora crassa, are very efficient in deconstructing plant biomass by the secretion of an arsenal of plant cell wall-degrading…”
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Voltage-dependent gating of SV channel TPC1 confers vacuole excitability
Published in Nature communications (14-06-2019)“…In contrast to the plasma membrane, the vacuole membrane has not yet been associated with electrical excitation of plants. Here, we show that mesophyll…”
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The Arabidopsis Auxin Receptor F-Box Proteins AFB4 and AFB5 Are Required for Response to the Synthetic Auxin Picloram
Published in G3 : genes - genomes - genetics (01-05-2016)“…The plant hormone auxin is perceived by a family of F-box proteins called the TIR1/AFBs. Phylogenetic studies reveal that these proteins fall into four clades…”
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CrY2H-seq: a massively multiplexed assay for deep-coverage interactome mapping
Published in Nature methods (01-08-2017)“…CrY2H-seq, a Cre recombinase reporter-mediated yeast two-hybrid method coupled with next-generation sequencing, enables ultra-high-throughput screening of…”
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PO236 A rare encounter with a common condition: encephalopathy in a tourist
Published in Journal of neurology, neurosurgery and psychiatry (01-12-2017)“…A 24 year old lady with a background of an arteriovenous malformation treated with the Gamma Knife. She had travelled extensively throughout South East Asia…”
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Rear-Lamp Vehicle Detection and Tracking in Low-Exposure Color Video for Night Conditions
Published in IEEE transactions on intelligent transportation systems (01-06-2010)“…Automated detection of vehicles in front is an integral component of many advanced driver-assistance systems (ADAS), such as collision mitigation, automatic…”
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Genome Sequencing
Published in Methods in molecular biology (Clifton, N.J.) (2018)“…Strategies for sequencing fungal genomes on next-generation sequencing (NGS) platforms depend on the characteristics of the genome of the targeted species,…”
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DNA affinity purification sequencing and transcriptional profiling reveal new aspects of nitrogen regulation in a filamentous fungus
Published in Proceedings of the National Academy of Sciences - PNAS (30-03-2021)“…Sensing available nutrients and efficiently utilizing them is a challenge common to all organisms. The model filamentous fungus Neurospora crassa is capable of…”
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The role of ATXR6 expression in modulating genome stability and transposable element repression in Arabidopsis
Published in Proceedings of the National Academy of Sciences - PNAS (18-01-2022)“…ARABIDOPSIS TRITHORAX-RELATED PROTEIN 5 (ATXR5) AND ATXR6 are required for the deposition of H3K27me1 and for maintaining genomic stability in Reduction of…”
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The landscape of Chlamydomonas histone H3 lysine 4 methylation reveals both constant features and dynamic changes during the diurnal cycle
Published in The Plant journal : for cell and molecular biology (01-10-2022)“…SUMMARY Chromatin modifications are epigenetic regulatory features with major roles in various cellular events, yet they remain understudied in algae. We…”
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