Search Results - "O'MALLEY, Stacey S"

In Vivo Evaluation and Dosimetry Estimate for a High Affinity Affibody PET Tracer Targeting PD-L1 by Rubins, Daniel J, Meng, Xiangjun, McQuade, Paul, Klimas, Michael, Getty, Krista, Lin, Shu-An, Connolly, Brett M., O’Malley, Stacey S., Haley, Hyking, Purcell, Mona, Gantert, Liza, Holahan, Marie, Lindgren, Joel, Eklund, Pär, Ekblad, Caroline, Frejd, Fredrik Y., Hostetler, Eric D., González Trotter, Dinko E., Evelhoch, Jeffrey L.

“…Purpose In vivo imaging of programmed death ligand 1 (PD-L1) during immunotherapy could potentially monitor changing PD-L1 expression and PD-L1 expression…”
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Synthesis and Evaluation of 5-Fluoro-2-aryloxazolo[5,4-b]pyridines as β-Amyloid PET Ligands and Identification of MK-3328 by Harrison, Scott T, Mulhearn, James, Wolkenberg, Scott E, Miller, Patricia J, O’Malley, Stacey S, Zeng, Zhizhen, Williams, David L, Hostetler, Eric D, Sanabria-Bohórquez, Sandra, Gammage, Linda, Fan, Hong, Sur, Cyrille, Culberson, J. Christopher, Hargreaves, Richard J, Cook, Jacquelynn J, Hartman, George D, Barrow, James C

“…5-Fluoro-2-aryloxazolo[5,4-b]pyridines were synthesized and investigated as potential 18F containing β-amyloid PET ligands. In competition binding assays using…”
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A novel radioligand for glycine transporter 1: characterization and use in autoradiographic and in vivo brain occupancy studies by Zeng, Zhizhen, O'Brien, Julie A, Lemaire, Wei, O'Malley, Stacey S, Miller, Patricia J, Zhao, Zhijian, Wallace, Michael A, Raab, Conrad, Lindsley, Craig W, Sur, Cyrille, Williams, David L

“…Abstract Introduction In an effort to develop agents to test the NMDA hypofunction hypothesis of schizophrenia, benchmark compounds from a program to discover…”
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In Vivo Imaging of the Programmed Death Ligand 1 by 18 F PET by González Trotter, Dinko E, Meng, Xiangjun, McQuade, Paul, Rubins, Daniel, Klimas, Michael, Zeng, Zhizhen, Connolly, Brett M, Miller, Patricia J, O'Malley, Stacey S, Lin, Shu-An, Getty, Krista L, Fayadat-Dilman, Laurence, Liang, Linda, Wahlberg, Elisabet, Widmark, Olof, Ekblad, Caroline, Frejd, Fredrik Y, Hostetler, Eric D, Evelhoch, Jeffrey L

“…Programmed death ligand 1 (PD-L1) is an immune regulatory ligand that binds to the T-cell immune check point programmed death 1. Tumor expression of PD-L1 is…”
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IN VITRO BINDING STUDIES TO EVALUATE THE NFT-SPECIFICITY OF [3H]MK-6240 AND [3H]AV-1451 BINDING IN SUBCORTICAL REGIONS OF THE HUMAN AD BRAIN by Zeng, Zhizhen, Miller, Patricia J., Connolly, Brett M., O’Malley, Stacey S., Lohith, Talakad, Bennacef, Idriss, Mulhearn, James, Schenk, David J., Hesk, David, Walji, Abbas, Sur, Cyrille, Li, Wenping, Hostetler, Eric D., Evelhoch, Jeffrey

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IN VITRO BINDING STUDIES TO EVALUATE THE NFT-SPECIFICITY OF [3H]MK-6240 AND [3H]AV-1451 BINDING IN SUBCORTICAL REGIONS OF HUMAN AD BRAIN by Zeng, Zhizhen, Miller, Partricia J., Connolly, Brett M., O’Malley, Stacey S., Lohith, Talakad, Mulhearn, James, Bennacef, Idriss, Walji, Abbas, Schenk, David J., Hesk, David, Sur, Cyrille, Li, Wenping, Hostetler, Eric D., Evelhoch, Jeffrey

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In Vivo Imaging of the Programmed Death Ligand 1 by 18F PET by González Trotter, Dinko E, Meng, Xiangjun, McQuade, Paul, Rubins, Daniel, Klimas, Michael, Zeng, Zhizhen, Connolly, Brett M, Miller, Patricia J, O'Malley, Stacey S, Lin, Shu-An, Getty, Krista L, Fayadat-Dilman, Laurence, Liang, Linda, Wahlberg, Elisabet, Widmark, Olof, Ekblad, Caroline, Frejd, Fredrik Y, Hostetler, Eric D, Evelhoch, Jeffrey L

“…Programmed death ligand 1 (PD-L1) is an immune regulatory ligand that binds to the T-cell immune check point programmed death 1. Tumor expression of PD-L1 is…”
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Synthesis, characterization, and first successful monkey imaging studies of metabotropic glutamate receptor subtype 5 (mGluR5) PET radiotracers by Hamill, Terence G., Krause, Stephen, Ryan, Christine, Bonnefous, Celine, Govek, Steve, Seiders, T. Jon, Cosford, Nicholas D.P., Roppe, Jeffrey, Kamenecka, Ted, Patel, Shil, Gibson, Raymond E., Sanabria, Sandra, Riffel, Kerry, Eng, Waisi, King, Christopher, Yang, Xiaoqing, Green, Mitchell D., O'malley, Stacey S., Hargreaves, Richard, Burns, H. Donald

“…Three metabotropic glutamate receptor subtype 5 (mGluR5) PET tracers have been labeled with either carbon‐11 or fluorine‐18 and their in vitro and in vivo…”
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Potent and orally active angiotensin II receptor antagonists with equal affinity for human AT1 and AT2 subtypes by Chang, Linda L, Ashton, Wallace T, Flanagan, Kelly L, Chen, Tsing-Bau, O'Malley, Stacey S, Zingaro, Gloria J, Kivlighn, Salah D, Siegl, Peter K. S, Lotti, Victor J

“…In order to block the effects induced by the interactions between angiotensin II (AII) and both AT1 and AT2 receptors, we have pursued the discovery of orally…”
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In Vivo Imaging of the Programmed Death Ligand 1 by F-18 PET by Trotter, Dinko E. Gonzalez, Meng, Xiangjun, McQuade, Paul, Rubins, Daniel, Klimas, Michael, Zeng, Zhizhen, Connolly, Brett M., Miller, Patricia J., O'Malley, Stacey S., Lin, Shu-An, Getty, Krista L., Fayadat-Dilman, Laurence, Liang, Linda, Wahlberg, Elisabet, Widmark, Olof, Ekblad, Caroline, Frejd, Fredrik Y., Hostetler, Eric D., Evelhoch, Jeffrey L.

“…Programmed death ligand 1 (PD-L1) is an immune regulatory ligand that binds to the T-cell immune check point programmed death 1. Tumor expression of PD-L1 is…”
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Benzodiazepines as Potent and Selective Bradykinin B1 Antagonists by Wood, Michael R, Kim, June J, Han, Wei, Dorsey, Bruce D, Homnick, Carl F, DiPardo, Robert M, Kuduk, Scott D, MacNeil, Tanya, Murphy, Kathy L, Lis, Edward V, Ransom, Richard W, Stump, Gary L, Lynch, Joseph J, O'Malley, Stacey S, Miller, Patricia J, Chen, Tsing-Bau, Harrell, Charles M, Chang, Raymond S. L, Sandhu, Punam, Ellis, Joan D, Bondiskey, Peter J, Pettibone, Douglas J, Freidinger, Roger M, Bock, Mark G

“…Antagonism of the bradykinin B1 receptor was demonstrated to be a potential treatment for chronic pain and inflammation. Novel benzodiazepines were designed…”
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Pharmacological characterization and radioligand binding properties of a high-affinity, nonpeptide, bradykinin B1 receptor antagonist by RANSOM, Richard W, HARRELL, Charles M, SU, Dai-Shi, MARKOWITZ, M. Kristine, WALLACE, Michael A, RAAB, Conrad E, JONES, Allen N, DEAN, Dennis C, PETTIBONE, Douglas J, FREIDINGER, Roger M, BOCK, Mark G, REISS, Duane R, MURPHY, Kathryn L, CHANG, Raymond S. L, HESS, J. Fred, MILLER, Patricia J, O'MALLEY, Stacey S, HEY, Pat J, KUNAPULI, Priya

“…Compound A (N-[2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl]-2-[(2R)-1-(2-napthylsulfonyl)-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl]acetamide) is a member of…”
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COMPARING [3 H]MK-6240 AND [3 H]AV-1451(T-807) IN IN VITRO BINDING STUDIES IN BRAIN TISSUES by Zeng, Zhizhen, Miller, Patricia J, Connolly, Brett M, O’Malley, Stacey S, Bennacef, Idriss, Mulhearn, James, David, Schenk J, Hesk, David, Soriano, Aileen, Abbas, Walji, Eric, Hostetler D

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COMPARING [3 H]MK-6240 AND [3 H]AV-1451(T-807) IN IN VITRO BINDING STUDIES IN BRAIN TISSUES by Zeng, Zhizhen, Miller, Patricia J, Connolly, Brett M, O’Malley, Stacey S, Bennacef, Idriss, Mulhearn, James, Schenk, David J, Hesk, David, Soriano, Aileen, Abbas, Walji, Hostetler, Eric D

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DISCOVERY AND FIRST-IN-HUMAN EVALUATION OF THE TAU-IMAGING PET RADIOTRACER [18 F]MK-6240 by Bennacef, Idriss, Zeng, Zhizhen, Lohith, Talakad, Miller, Patricia J, Salinas, Cristian A, Connolly, Brett M, Gantert, Liza T, Hyking, Haley D, Holahan, Marie A, O’Malley, Stacey S, Purcell, Mona L, Riffel, Kerry, Coleman, Paul J, Li, Jing, Balsells-Padros, Jaume, Soriano, Aileen, Ogawa, Aimie M, Xu, Serena, Xiaoping, Zhang, Della Rocca, Joseph, Schachter, Joel B, Hesk, David, Telan-Choing, Florestina, Struyk, Arie, Sur, Cyrille, Celen, Sofie, Serdons, Kim, Bormans, Guy, Vandenbulcke, Mathieu, Vandenberghe, Rik, De Hoon, Jan, Koole, Michel, Van Laere, Koen, Declercq, Ruben, Reynders, Tom, Abbas, Walji, Hostetler, Eric D, Evelhoch, Jeffrey

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DISCOVERY AND FIRST-IN-HUMAN EVALUATION OF THE TAU-IMAGING PET RADIOTRACER [18 F]MK-6240 by Bennacef, Idriss, Zeng, Zhizhen, Lohith, Talakad, Miller, Patricia J, Salinas, Cristian A, Connolly, Brett M, Gantert, Liza T, Haley, Hyking D, Marie, Holahan A, O’Malley, Stacey S, Purcell, Mona L, Riffel, Kerry, Coleman, Paul J, Li, Jing, Balsells-Padros, Jaume, Soriano, Aileen, Ogawa, Aimie M, Xu, Serena, Xiaoping, Zhang, Della Rocca, Joseph, Schachter, Joel B, Hesk, David, David, Schenk J, Telan-Choing, Florestina, Struyk, Arie, Sur, Cyrille, Celen, Sofie, Serdons, Kim, Bormans, Guy, Vandenbulcke, Mathieu, Vandenberghe, Rik, De Hoon, Jan, Koole, Michel, Van Laere, Koen, Declercq, Ruben, Tom, Reynders, Abbas, Walji, Eric, Hostetler D, Evelhoch, Jeffrey

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Triazolinone Biphenylsulfonamides as Angiotensin II Receptor Antagonists with High Affinity for Both the AT1 and AT2 Subtypes by Chang, Linda L, Ashton, Wallace T, Flanagan, Kelly L, Chen, Tsing-Bau, O'Malley, Stacey S, Zingaro, Gloria J, Siegl, Peter K. S, Kivlighn, Salah D, Lotti, Victor J

“…Angiotensin II (AII), the endogenous peptide ligand of the AII receptor, has equivalent high affinity for both the AT1 and AT2 receptor subtypes while most of…”
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De Novo Design of a Novel Oxazolidinone Analogue as a Potent and Selective α1A Adrenergic Receptor Antagonist with High Oral Bioavailability by Lagu, Bharat, Tian, Dake, Jeon, Yoon, Li, Chao, Wetzel, John M, Nagarathnam, Dhanapalan, Shen, Quanrong, Forray, Carlos, Chang, Raymond S. L, Broten, Theodore P, Ransom, Richard W, Chan, Tsing-Bao, O'Malley, Stacey S, Schorn, Terry W, Rodrigues, A. David, Kassahun, Kelem, Pettibone, Douglas J, Freidinger, Roger, Gluchowski, Charles

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In Vitro and in Vivo Evaluation of Dihydropyrimidinone C-5 Amides as Potent and Selective α1A Receptor Antagonists for the Treatment of Benign Prostatic Hyperplasia by Barrow, James C, Nantermet, Philippe G, Selnick, Harold G, Glass, Kristen L, Rittle, Kenneth E, Gilbert, Kevin F, Steele, Thomas G, Homnick, Carl F, Freidinger, Roger M, Ransom, Rick W, Kling, Paul, Reiss, Duane, Broten, Theodore P, Schorn, Terry W, Chang, Raymond S. L, O'Malley, Stacey S, Olah, Timothy V, Ellis, Joan D, Barrish, Andrea, Kassahun, Kelem, Leppert, Paula, Nagarathnam, Dhanapalan, Forray, Carlos

“…α1 Adrenergic receptors mediate both vascular and lower urinary tract tone, and α1 receptor antagonists such as terazosin (1b) are used to treat both…”
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Characterization of specific binding of [formula omitted]L-762,459, a selective α1A-adrenoceptor radioligand to rat and human tissues by O'Malley, Stacey S, Chen, Tsing B, Francis, Barbara E, Gibson, Raymond E, Burns, H.Donald, DiSalvo, Jerry, Bayne, Marvin L, Wetzel, John M, Nagarathnam, Dhanapalan, Marzabadi, Mohammad, Gluchowski, Charles, Chang, Raymond S.L

“…L-762,459…”
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